Patents by Inventor Edward G. Jablonski

Edward G. Jablonski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
    Patent number: 5976501
    Abstract: Conventional ultrasonic imaging methods are described which involve the use of aqueous suspension of microspheres. These microspheres are further characterized as consisting of gas cores encapsulated by a protein shell which are formed in the presence of perfluoroalkane vapors. The presence of the vapor during formation changes the shell characteristics and thus protects the gas from being solubilized in the surrounding aqueous environment. In addition, the presence of the perfluoroalkane vapor during formation may also provide improved echogenic properties for vascular imaging applications.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: November 2, 1999
    Assignee: Molecular Biosystems, Inc.
    Inventor: Edward G. Jablonski
  • Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
    Patent number: 5855865
    Abstract: Elastic protein microspheres, filled with water insoluble gases, have been produced by ultrasound and mechanical cavitation without the present of oxygen. The microspheres are highly echogenic. The microspheres exhibit greatly enhanced static pressure stability, up to 40 psig. The microspheres are resistant to coalescence and to expansion due to differential gas diffusion. The microspheres are resistant to collapse when suspended in a gas-depleted aqueous solution.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: January 5, 1999
    Assignee: Molecular Biosystems, Inc.
    Inventors: Karel J. Lambert, Sheila Benay Podell, Edward G. Jablonski, Carl Hulle, Kenneth Hamilton, Rolf Lohrmann
  • Gas-exchange method of making gas-filled microspheres
    Patent number: 5674469
    Abstract: Ultrasonic imaging agents comprising an insoluble gas may be made by a new process of gas exchange. A solution is supersaturated with the insoluble gas and then contacted with a conventional air-filled microsphere suspension in order to effectuate a gas exchange process. The insoluble gas-containing microsphere exhibits increased pressure resistance and stability over microspheres in which the gas exchange was performed passively.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Molecular Biosystems, Inc.
    Inventor: Edward G. Jablonski
  • Liquid core microdroplets for ultrasound imaging
    Patent number: 5606973
    Abstract: Ultrasonic imaging agents comprising an aqueous suspension of negatively buoyant aspherical microdroplets composed of a biocompatible liquid core encapsulated by a shell of amphiphilic biocompatible material are prepared by milling a mixture of a solution of the shell material and vaporized liquid and cooling the milled mixture to below the boiling point of the liquid.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 4, 1997
    Assignee: Molecular biosystems, Inc.
    Inventors: Karel J. Lambert, Edward G. Jablonski
  • Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent
    Patent number: 5552133
    Abstract: Encapsulated gas microspheres useful as an ultrasonic imaging agent are made by: mixing an aqueous solution of a heat-denaturable protein with a gas, and passing the gas-solution mixture through a mill whereby the mixture is emulsified near the denaturation temperature of the protein and subjected to mechanical shearing and cavitation which causes the formation of gas bubbles in the 0.1 to 10 micron range, and the protein to locally denature and deposit at the gas-liquid interface to form the encapsulated microspheres.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: September 3, 1996
    Assignee: Molecular Biosystems, Inc.
    Inventors: Karel J. Lambert, Edward G. Jablonski, Carl Hulle