Abstract: The present disclosure relates to PDE9 inhibitors, pharmaceutical compositions comprising the PDE9 inhibitors, and methods of using the PDE9 pharmaceutical compositions for the treatment of sickle cell disease (SCD).

Abstract: This invention provides novel oral dosage forms comprising a hops extract. The oral dosage forms are capable of activating bitter taste receptors expressed in the gastrointestinal tract. The applications include but are not limited to the use of the oral dosage forms for reducing energy intake and/or appetite in a subject.

Abstract: A device may include an interior component having an outer diameter (OD) surface. A device may include a protective housing positioned around at least a portion of the interior component and having an inner diameter (ID) surface proximate the OD surface of the interior component. A device may include an adjustable damper positioned between the ID surface and the OD surface and configured to change size in a transverse direction perpendicular to a longitudinal axis of the interior component.

Abstract: The present disclosure relates to PDE9 inhibitors, pharmaceutical compositions comprising the PDE9 inhibitors, and methods of using the PDE9 pharmaceutical compositions for the treatment of sickle cell disease (SCD).

Abstract: A pressure pulse generator and an RSS may change the pressure of a fluid flow through a BHA. If the dogleg at the BHA is less than a target dogleg, then the pressure pulse generator goes into pass-through mode to increase the pressure at the RSS and thereby increase a pad force of the RSS steering pads, increasing the severity of the dogleg. If a downhole tool is stuck, then the pressure pulse generator and the RSS are simultaneously actuated to unstick the downhole tool. The RSS is used to generate and transmit pressure pulses to a downhole tool.

Abstract: Systems, apparatuses, and methods for implementing content adaptive processing via ringing estimation and suppression are disclosed. A ring estimator estimates the amount of ringing when a wide filter kernel is used for image processing. The amount of ringing can be specified as an under-shoot or an over-shoot. A blend factor calculation unit determines if the estimated amount of ringing is likely to be visually objectionable. If the ringing is likely to be visually objectionable, then the blend factor calculation unit generates a blend factor value to suppress the objectionable ringing. The blend factor value is generated for each set of source pixels based on this determination. The blend factor value is then applied to how the blending is mixed between narrow and wide filters for the corresponding set of source pixels. The preferred blending between the narrow and wide filters is changeable on a pixel-by-pixel basis during image processing.

Abstract: A cooking device drainage system is provided. In one embodiment, a cooking device drainage system includes a seal positioned between a door and a housing of an appliance. The seal is configured to be attached to the door and at least partially define a seal channel configured to receive condensation from an interior surface of the door. The seal includes a channel opening therein. A catch is positioned between the housing and the door and includes a drain opening passing therethrough. The catch is configured to receive a flow of condensation from the channel opening. A collection channel is coupled to the housing below the door and is configured to receive and retain the flow of condensation from the drain opening.

Abstract: A pressure pulse generator and an RSS may change the pressure of a fluid flow through a BHA. If the dogleg at the BHA is less than a target dogleg, then the pressure pulse generator goes into pass-through mode to increase the pressure at the RSS and thereby increase a pad force of the RSS steering pads, increasing the severity of the dogleg. If a downhole tool is stuck, then the pressure pulse generator and the RSS are simultaneously actuated to unstick the downhole tool. The RSS is used to generate and transmit pressure pulses to a downhole tool.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may monitor a set of resources for one or more synchronization signal blocks (SSBs) associated with one or more pseudo-random sequences. The one or more pseudo-random sequences and the set of resources may be indicated by an output of a pseudo-random function (PRF) that is based on a timing parameter, a cell identifier, and a key. In some examples, the UE may monitor a set of resources within a control resource set for a downlink control channel, where the set of resources for the downlink control channel is based on an output of the PRF. The UE communicate with a network entity via a cell associated with the cell identifier based on the monitoring.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) and a network entity may pseudo-randomly generate frequency hopping indexes to support secure communication of sounding reference signals (SRSs). For example, the UE may securely obtain a key associated with communication a set of SRSs via respective portions of system bandwidth for communicating with the network entity. The UE and the network entity may generate a set of frequency hopping indexes using the key. The set of frequency hopping indexes may correspond to the set of SRSs, and each frequency hopping index may indicate a respective portion of the system bandwidth for communication of a corresponding SRS. The UE and the network entity may communicate the set of SRSs in accordance with the set of frequency hopping indexes.

Abstract: Methods, systems, and devices for wireless communication are described. A user equipment (UE) may monitor a set of time-frequency resources for one or more cell detection signals (CDS) associated with a pseudo-random sequence, where the pseudo-random sequence and the set of time-frequency resources are indicated by an output of a pseudo-random function (PRF) that is based on a timing parameter, a cell identifier (ID), and a shared key. Accordingly, the UE may communicate with a network entity via a cell associated with the cell ID based on receiving the one or more CDS. The UE may also exchange one or more messages with the network entity, and may perform a time calibration procedure based on the one or more messages and a delay threshold of the UE. The one or more messages may indicate an ID of the UE, a cryptographic number, a time interval, or a combination thereof.

Abstract: A circuit for sharing current between parallel LEDs or parallel strings of LEDs, and a method of use of the same, are disclosed herein. The circuit for sharing current between parallel LED pathways can include a first LED pathway, a first transistor coupled to the first set of LEDs and that can control a first current through the first set of LEDs, and a first measurement node having a first sensed voltage. The circuit can include a second LED pathway, a second transistor coupled to the second set of LEDs and that can control a second current through the second set of LEDs, and a second measurement node having a second sensed voltage. The circuit includes a first differential amplifier and a second differential amplifier, each of which can compare sensed voltage and can apply a voltage to a gate of one of the first and second transistors.

Abstract: This invention provides novel oral dosage forms comprising a hops extract. The oral dosage forms are capable of activating bitter taste receptors expressed in the gastrointestinal tract. The applications include but are not limited to the use of the oral dosage forms for reducing energy intake and/or appetite in a subject.

Abstract: A novel device component in a digital healthcare framework adds context to physiological sensor data, where such context data includes a first unique identifier associated with the device and a second unique identifier associated with the user who the physiological data belongs to. The physiological sensor data along with the context data is then encrypted and transmitted via an encrypted channel to a coordination gateway.

Abstract: A coordination gateway component in a digital healthcare framework receives data from a device component and adds annotations to physiological sensor data, where such annotations include medical/domain code information, clinical validation information, and regulatory compliance information. The annotated data is then sent to a data distribution gateway component of the digital healthcare framework.

Abstract: A novel data distribution gateway component in a digital healthcare framework stores physiological sensor data enhanced with contextual data, where such contextual data comprises a physiological sensor data point generated at a device component, a user ID that was added by the device component, a device ID that was added by the device component, a timestamp that was added by device component, medical/code annotation data added by a coordination gateway, clinical validation annotation data added by the coordination gateway, and regulatory compliance annotation data added by the coordination gateway.

Abstract: A novel set of graphical user interfaces are used in combination with a data distribution gateway component in a digital healthcare framework, wherein the data distribution gateway stores physiological sensor data enhanced with contextual data, where such contextual data comprises a physiological sensor data point generated at a device component, a user ID that was added by the device component, a device ID that was added by the device component, a timestamp that was added by device component, medical/code annotation data added by a coordination gateway, clinical validation annotation data added by the coordination gateway, and regulatory compliance annotation data added by the coordination gateway.

Abstract: This invention provides novel oral dosage forms comprising a hops extract. The oral dosage forms are capable of activating bitter taste receptors expressed in the gastrointestinal tract. The applications include but are not limited to the use of the oral dosage forms for reducing energy intake and/or appetite in a subject.