Patents by Inventor Edward Goetzl

Edward Goetzl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endothelial Cell Derived Exosomes and Uses Thereof
    Publication number: 20220057501
    Abstract: The present invention relates to endothelial cell biomarkers and diagnostic and prognostic methods for vascular diseases, including cardiovascular and cerebrovascular diseases. The invention also provides compositions for detecting endothelial cell biomarkers (e.g., endothelial cell-derived exosome biomarkers) as well as compositions and methods useful for treating vascular diseases (e.g., atherosclerotic cerebrovascular disease).
    Type: Application
    Filed: November 7, 2021
    Publication date: February 24, 2022
    Inventor: Edward Goetzl
  • Endothelial cell derived exosomes and uses thereof
    Patent number: 11193943
    Abstract: The present invention relates to endothelial cell biomarkers and diagnostic and prognostic methods for vascular diseases, including cardiovascular and cerebrovascular diseases. The invention also provides compositions for detecting endothelial cell biomarkers (e.g., endothelial cell-derived exosome biomarkers) as well as compositions and methods useful for treating vascular diseases (e.g., atherosclerotic cerebrovascular disease).
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: December 7, 2021
    Inventor: Edward Goetzl
  • Purification, extraction and analyses of fetal neurally-derived exosomes in maternal blood and neonatal neurally-derived exosomes from neonatal blood
    Patent number: 10962555
    Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: March 30, 2021
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Laura Goetzl, Edward Goetzl
  • Purification, extraction and analyses of fetal neurally-derived exosomes in maternal blood and neonatal neurally-derived exosomes from neonatal blood
    Publication number: 20190025329
    Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 24, 2019
    Inventors: Laura Goetzl, Edward Goetzl
  • Endothelial Cell Derived Exosomes and Uses Thereof
    Publication number: 20180224465
    Abstract: The present invention relates to endothelial cell biomarkers and diagnostic and prognostic methods for vascular diseases, including cardiovascular and cerebrovascular diseases. The invention also provides compositions for detecting endothelial cell biomarkers (e.g., endothelial cell-derived exosome biomarkers) as well as compositions and methods useful for treating vascular diseases (e.g., atherosclerotic cerebrovascular disease).
    Type: Application
    Filed: September 13, 2017
    Publication date: August 9, 2018
    Inventor: Edward Goetzl
  • Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
    Publication number: 20060073515
    Abstract: Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated.
    Type: Application
    Filed: August 16, 2002
    Publication date: April 6, 2006
    Inventors: Edward Goetzl, Songzhu An
  • Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
    Patent number: 6812335
    Abstract: Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: November 2, 2004
    Assignee: The Regents of the University of California
    Inventors: Edward Goetzl, Songzhu An