Patents by Inventor Edward H. Bohl

Edward H. Bohl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cultivatable human rotavirus type 2
    Patent number: 4341870
    Abstract: This invention relates to a precursor or intermediate for a rotavirus vaccine to protect infants and young children against diarrhea caused by rotavirus. The invention is the efficient propagation of a strain of human rotavirus type 2 prepared by a method of cultivation by multiple passages in vivo in gnotobiotic piglets and by multiple passages in vitro subsequently in AGMK (African green monkey kidney) cell cultures. Additionally, rotavirus is treated with a biologically active amount of trypsin prior to growth in AGMK cells, and the inoculated cell cultures are centrifuged at a low centrifugal force before incubation.
    Type: Grant
    Filed: November 19, 1980
    Date of Patent: July 27, 1982
    Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
    Inventors: Richard G. Wyatt, Walter D. James, Edward H. Bohl, Kenneth W. Theil, Linda J. Saif, Anthony R. Kalica, Harry B. Greenberg, Albert Z. Kapikian, Robert M. Chanock