Patents by Inventor Edward H. Cohen

Edward H. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL METHODS OF CONSTRUCTING LIBRARIES COMPRISING DISPLAYED AND/OR EXPRESSED MEMBERS OF A DIVERSE FAMILY OF PEPTIDES, POLYPEPTIDES OR PROTEINS AND THE NOVEL LIBRARIES
    Publication number: 20210087256
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: August 4, 2020
    Publication date: March 25, 2021
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
    Patent number: 10829541
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: November 10, 2020
    Assignee: Dyax Corp.
    Inventors: Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • NOVEL METHODS OF CONSTRUCTING LIBRARIES COMPRISING DISPLAYED AND/OR EXPRESSED MEMBERS OF A DIVERSE FAMILY OF PEPTIDES, POLYPEPTIDES OR PROTEINS AND THE NOVEL LIBRARIES
    Publication number: 20170369557
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 28, 2017
    Applicant: Dyax Corp.
    Inventors: Robert Charles Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
    Patent number: 9382535
    Abstract: Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: July 5, 2016
    Assignee: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet
  • Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
    Patent number: 8901045
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods are disclose. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens are also disclosed.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: December 2, 2014
    Assignee: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Metalloproteinase 9 binding proteins
    Patent number: 8455205
    Abstract: Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: June 4, 2013
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, David Buckler, Edward H. Cohen
  • NOVEL METHODS OF CONSTRUCTING LIBRARIES COMPRISING DISPLAYED AND/OR EXPRESSED MEMBERS OF A DIVERSE FAMILY OF PEPTIDES, POLYPEPTIDES OR PROTEINS AND THE NOVEL LIBRARIES
    Publication number: 20130040861
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods are disclose. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens are also disclosed.
    Type: Application
    Filed: May 4, 2012
    Publication date: February 14, 2013
    Applicant: DYAX CORP.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
    Patent number: 8288322
    Abstract: A library containing a collection of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and that collectively display at least a portion of the family, the displayed peptides, polypeptides or proteins being encoded by DNA sequences containing sequences encoding a heavy chain CDR region is described.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: October 16, 2012
    Assignee: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Conformation specific antibodies
    Patent number: 8247185
    Abstract: The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1 ”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: August 21, 2012
    Assignees: DYAX Corp., The CBR Institute for Biomedical Research, Inc.
    Inventors: Edward H. Cohen, Isaac J. Rondon, Timothy A. Springer, Motomu Shimaoka
  • METALLOPROTEINASE 9 BINDING PROTEINS
    Publication number: 20120027774
    Abstract: Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.
    Type: Application
    Filed: July 26, 2011
    Publication date: February 2, 2012
    Applicant: DYAX CORP.
    Inventors: Laetitia Devy, David Buckler, Edward H. Cohen
  • USE OF IGF-II/IGF-IIE BINDING PROTEINS FOR THE TREATMENT AND PREVENTION OF SYSTEMIC SCLEROSIS ASSOCIATED PULMONARY FIBROSIS
    Publication number: 20110262446
    Abstract: Methods of using proteins that bind to IGF-II and/or IGF-IIE for the treatment or prevention of systemic sclerosis-associated pulmonary fibrosis are described.
    Type: Application
    Filed: October 14, 2009
    Publication date: October 27, 2011
    Applicant: DYAX CORP.
    Inventor: Edward H. Cohen
  • CONFORMATION SPECIFIC ANTIBODIES
    Publication number: 20110212112
    Abstract: The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.
    Type: Application
    Filed: March 8, 2011
    Publication date: September 1, 2011
    Applicant: CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.
    Inventors: Edward H. Cohen, Isaac J. Rondon, Timothy A. Springer, Motomu Shimaoka
  • Metalloproteinase 9 binding proteins
    Patent number: 8008445
    Abstract: Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: August 30, 2011
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, David Buckler, Edward H. Cohen
  • IGF-II/IGF-IIE BINDING PROTEINS
    Publication number: 20110165145
    Abstract: Proteins that bind to IGF-II and/or IGF-IIE and methods of using such proteins are described. Also disclosed are new methods for treatment of cancer. Cancer is treated by administration of an IGF-II/IGF-IIE binding protein and an additional therapy such as a growth hormone/growth hormone releasing hormone pathway modulator or epidermal growth factor receptor inhibitor.
    Type: Application
    Filed: May 8, 2009
    Publication date: July 7, 2011
    Inventors: Daniel T. Dransfield, Edward H. Cohen, Timothy Adams, Leah Cosgrove
  • Conformation specific antibodies
    Patent number: 7927591
    Abstract: The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: April 19, 2011
    Assignee: The CBR Institute for Biomedical Research, Inc.
    Inventors: Edward H. Cohen, Isaac J. Rondon, Timothy A. Springer, Motomu Shimaoka
  • METALLOPROTEINASE 9 BINDING PROTEINS
    Publication number: 20090311245
    Abstract: Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.
    Type: Application
    Filed: March 3, 2009
    Publication date: December 17, 2009
    Applicant: DYAX CORP.
    Inventors: Laetitia Devy, David Buckler, Edward H. Cohen
  • Conformation Specific Antibodies
    Publication number: 20080069777
    Abstract: The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 (“aLFA-1”), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.
    Type: Application
    Filed: February 22, 2005
    Publication date: March 20, 2008
    Inventors: Edward H. Cohen, Isaac J. Rondon, Timothy A. Springer, Motomu Shimaoka
  • Serum albumin binding moieties
    Patent number: 7211395
    Abstract: Compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum albumin molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to albumin. Preferred serum albumin binding peptides having a high affinity for human serum albumin are particularly disclosed.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: May 1, 2007
    Assignee: Dyax Corp.
    Inventors: Aaron K. Sato, Arthur C. Ley, Edward H. Cohen
  • Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
    Publication number: 20040029113
    Abstract: The present invention relates to constructing libraries of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and collectively display at least a portion of the diversity of the family. In a preferred embodiment, the displayed polypeptides are human Fabs.
    Type: Application
    Filed: April 17, 2001
    Publication date: February 12, 2004
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet
  • Novel methods of constructing librabries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel librabries
    Publication number: 20030232333
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: October 25, 2001
    Publication date: December 18, 2003
    Applicant: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom