Patents by Inventor Edward H. Liao

Edward H. Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR IDENTIFYING VARIANTS IN GENE PRODUCTS FROM GENE CONSTRUCTS USED IN CELL THERAPY APPLICATIONS
    Publication number: 20230103457
    Abstract: A method for ensuring that gene products used in cell therapy do not carry a risk of reduced efficacy or toxicity due to production of unintended variants. The method includes performing an in-silico analysis on the gene construct to identify and alter sequences likely to cause variants. Also, the method includes performing an in-vivo analysis consisting of RNA-sequence of construct based products. Variant detection may then be performed based on gapped reads from the RNA-sequence to determine variant expression levels, variant significance. The method may include repeating the in-silico analysis if identified variants are unacceptable.
    Type: Application
    Filed: June 29, 2022
    Publication date: April 6, 2023
    Inventors: Jorge Andrade, Eugene Bolotin, Alexander S. Falk, Edward H. Liao
  • CHIMERIC ANTIGEN RECEPTOR
    Publication number: 20230013874
    Abstract: Provided are chimeric antigen receptors (CARs) comprising an NGK2D ecto domain. Provided are compositions, cells and cell therapies comprising the same. Further provided are methods of treatment.
    Type: Application
    Filed: May 23, 2022
    Publication date: January 19, 2023
    Inventors: Kevin P. Meng, Jodi Murakami, Samuel T. Haile, Edward H. Liao