Patents by Inventor Edward H. Schuchman

Edward H. Schuchman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the modulation of acid-sphingomyelinase-related apoptosis
    Patent number: 6790627
    Abstract: The present invention relates, first, to methods for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to, environmental stress-induced apoptosis such as, for example, ionizing radiation and/or chemotherapeutic agent-induced apoptosis. Apoptosis can be characterized by a cellular morphology comprising cellular condensation, nuclear condensation or zeiosis. The present invention further relates to methods for the identification of compounds which modulate (i.e., either increase or decrease) sensitivity to ASM-related processes, including apoptosis.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: September 14, 2004
    Assignees: Sloan-Kettering Institute for Cancer Research, Mount Sinai School of Medicine of New York University
    Inventors: Richard Kolesnick, Edward H. Schuchman
  • Acid sphingomyelinase gene and diagnosis of Niemann-pick disease
    Publication number: 20030153739
    Abstract: The present invention relates to the acid sphingomyelinase gene and to methods of diagnosing Niemann-Pick disease. It is based, at least in part, on the cloning and expression of the full-length cDNA encoding acid sphingomyelinase and on the discovery of mutations in the acid sphingomyelinase gene of Ashkenazi Jewish Niemann-Pick disease patients.
    Type: Application
    Filed: January 28, 2003
    Publication date: August 14, 2003
    Applicant: Mount Sinai Medical Center
    Inventors: Edward H. Schuchman, Robert J. Desnick
  • Acid sphingomyelinase protein and methods of treating type B Niemann-Pick disease
    Patent number: 6541218
    Abstract: The present invention relates to the acid sphingomyelinase gene and to methods of diagnosing Niemann-Pick disease. It is based, at least in part, on the cloning and expression of the full-length cDNA encoding acid sphingomyelinase and on the discovery of mutations in the acid sphingomyelinase gene of Ashkenazi Jewish Niemann-Pick disease patients.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: April 1, 2003
    Assignee: The Mount Sinai School of Medicine of the city University of New York
    Inventors: Edward H. Schuchman, Robert J. Desnick
  • Methods and compositions for the modulation of acid-sphingomyelinase-related apoptosis
    Publication number: 20010055774
    Abstract: The present invention relates, first, to methods and compositions for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to, environmental stress-induced apoptosis such as, for example, ionizing radiation and/or chemotherapeutic agent-induced apoptosis. Apoptosis can be characterized by a cellular morphology comprising cellular condensation, nuclear condensation or zeiosis. The present invention further relates to methods for the identification of compounds which modulate (i.e., either increase or decrease) sensitivity to ASM-related processes, including apoptosis.
    Type: Application
    Filed: August 13, 2001
    Publication date: December 27, 2001
    Applicant: Sloan-Kettering Institute for Cancer Research
    Inventors: Richard Kolesnick, Edward H. Schuchman
  • Method for the modulation of acid-sphingomyelinase-related apoptosis
    Patent number: 6274309
    Abstract: The present invention relates, first, to methods and compositions for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to, environmental stress-induced apoptosis such as, for example, ionizing radiation and/or chemotherapeutic agent-induced apoptosis. Apoptosis can be characterized by a cellular morphology comprising cellular condensation, nuclear condensation or zeiosis. The present invention further relates to methods for the identification of compounds which modulate (i.e., either increase or decrease) sensitivity to ASM-related processes, including apoptosis.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: August 14, 2001
    Inventors: Richard Kolesnick, Edward H. Schuchman
  • Acid sphingomyelinase gene
    Patent number: 5773278
    Abstract: The present invention relates to the acid sphingomyelinase gene and to methods of diagnosing Niemann-Pick disease. It is based, at least in part, on the cloning and expression of the full-length cDNA encoding acid sphingomyelinase and on the discovery of mutations in the acid sphingomyelinase gene of Ashkenazi Jewish Niemann-Pick disease patients.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: June 30, 1998
    Assignee: Mount Sinai Medical Center
    Inventors: Edward H. Schuchman, Robert J. Desnick
  • Acid sphingomyelinase gene and diagnosis of Niemann-Pick disease
    Patent number: 5686240
    Abstract: The present invention relates to the acid sphingomyelinase gene and to methods of diagnosing Niemann-Pick disease. It is based, at least in part, on the cloning and expression of the full-length cDNA encoding acid sphingomyelinase, the cloning and characterization of the genomic structure of the acid sphingomyelinase gene, and on the discovery of frequent mutations in the acid sphingomyelinase gene of Ashkenazi Jewish Niemann-Pick disease patients.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: November 11, 1997
    Assignee: Mount Sinai School of Medicine of the City University of New York
    Inventors: Edward H. Schuchman, Robert J. Desnick