Patents by Inventor Edward H. Trappler

Edward H. Trappler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus for lyophilization of products contained in product delivery units
    Patent number: 11054185
    Abstract: A carrier for supporting containers such as syringes or cartridges in a lyophilization chamber during lyophilization of substances contained therein, comprises a base assembly with an array of holes for receiving the containers. Each hole includes a heat-conductive metal portion for engagement with lower parts of the container held therein and a relatively non-conductive polymeric portion surrounding a portion of the container above the lower portion for enhancing the vertical growth of relatively large ice crystals. An upper part of the carrier supported above the base assembly includes a plunger-holding plate for frictionally holding elastomeric plungers and a pusher plate movable toward the plunger-holding plate and having protrusions for pushing the plungers out of the plunger-holding plate and into the containers before the containers are removed from the chamber.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: July 6, 2021
    Assignee: Lyophilization Technology, Inc.
    Inventors: Edward H. Trappler, Michael S. Thomas
  • Anthracycline formulations
    Patent number: 10328093
    Abstract: The invention relates to reconstituted formulations comprising an anthracycline compound, ethanol, and water. The invention also relates to injectable compositions comprising the reconstituted formulation and Lactated Ringer's solution. Additionally, the invention relates to methods of using the formulations and compositions.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 25, 2019
    Assignee: CytRx Corporation
    Inventors: Scott Geyer, Daniel Levitt, Carrie Nodgaard, Edward H. Trappler
  • Lyophilized cyclophosphamide composition and methods of preparation thereof
    Patent number: 10307431
    Abstract: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: June 4, 2019
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Andrew M. Smith, Timothy S. Dutill, Edward H. Trappler
  • Lyophilized cyclophosphamide composition and methods of preparation thereof
    Patent number: 10149857
    Abstract: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: December 11, 2018
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Andrew M. Smith, Timothy S. Dutill, Edward H. Trappler
  • Lyophilized Cyclophosphamide Composition and Methods of Preparation Thereof
    Publication number: 20180256609
    Abstract: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
    Type: Application
    Filed: November 15, 2017
    Publication date: September 13, 2018
    Inventors: Andrew M. SMITH, Timothy S. DUTILL, Edward H. TRAPPLER
  • Lyophilized Cyclophosphamide Composition and Methods of Preparation Thereof
    Publication number: 20180256608
    Abstract: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
    Type: Application
    Filed: March 9, 2017
    Publication date: September 13, 2018
    Inventors: Andrew M. SMITH, Timothy S. DUTILL, Edward H. TRAPPLER
  • ANTHRACYCLINE FORMULATIONS
    Publication number: 20170340655
    Abstract: The invention relates to reconstituted formulations comprising an anthracycline compound, ethanol, and water. The invention also relates to injectable compositions comprising the reconstituted formulation and Lactated Ringer's solution. Additionally, the invention relates to methods of using the formulations and compositions.
    Type: Application
    Filed: May 9, 2017
    Publication date: November 30, 2017
    Inventors: Scott Geyer, Daniel Levitt, Carrie Nodgaard, Edward H. Trappler
  • Lyophilization of synthetic liposomal pulmonary surfactant
    Patent number: 9554999
    Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: January 31, 2017
    Assignee: Windtree Therapeutics, Inc.
    Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
  • ANTHRACYCLINE FORMULATIONS
    Publication number: 20150342975
    Abstract: The invention relates to reconstituted formulations comprising an anthracycline compound, ethanol, and water. The invention also relates to injectable compositions comprising the reconstituted formulation and Lactated Ringer's solution. Additionally, the invention relates to methods of using the formulations and compositions.
    Type: Application
    Filed: December 13, 2013
    Publication date: December 3, 2015
    Applicant: CYTRX CORPORATION
    Inventors: Scott Geyer, Daniel Levitt, Carrie Nodgaard, Edward H. Trappler
  • LYOPHILIZATION OF SYNTHETIC LIPOSOMAL PULMONARY SURFACTANT
    Publication number: 20150297524
    Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.
    Type: Application
    Filed: March 28, 2013
    Publication date: October 22, 2015
    Applicant: Discovery Laboratories, Inc.
    Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
  • Lyophilization of synthetic liposomal pulmonary surfactant
    Patent number: 8748396
    Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. A method of making lyophilized pulmonary surfactants is described.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: June 10, 2014
    Assignee: Discovery Laboratories, Inc.
    Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
  • Lyophilization of synthetic liposomal pulmonary surfactant
    Patent number: 8748397
    Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: June 10, 2014
    Assignee: Discovery Laboratories, Inc.
    Inventors: Sergio Cesco-Cancian, Thomas Hoy, Edward H. Trappler, Michael S. Thomas
  • LYOPHILIZATION OF SYNTHETIC LIPOSOMAL PULMONARY SURFACTANT
    Publication number: 20140088025
    Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. A method of making lyophilized pulmonary surfactants is described.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: DISCOVERY LABORATORIES, INC.
    Inventors: Sergio CESCO-CANCIAN, Thomas HOY, Edward H. TRAPPLER, Michael S. THOMAS
  • LYOPHILIZATION OF SYNTHETIC LIPOSOMAL PULMONARY SURFACTANT
    Publication number: 20140088026
    Abstract: Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: DISCOVERY LABORATORIES, INC.
    Inventors: Sergio CESCO-CANCIAN, Thomas HOY, Edward H. TRAPPLER, Michael S. THOMAS
  • Freeze dry process and structure
    Patent number: 4597188
    Abstract: A vacuum-chamber, batch-process, freeze dryer system, of the type usable for pharmaceutical, diagnostic and chemical processing applications, incorporates extensive regulation of a carrier gas injected in minute quantities into an evacuated vacuum chamber and a distribution system which regulates a more even flow over each of a plurality of material holding containers held within the evacuated vacuum chamber of the carrier gas.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: July 1, 1986
    Inventor: Edward H. Trappler