Patents by Inventor Edward H. Wasmuth

Edward H. Wasmuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis B antigen
    Patent number: 4242324
    Abstract: An improved process for the preparation of hepatitis B antigen by subjecting plasma of hepatitis B donors to isopycanic banding wherein the step gradient is NaBr. Faster and more economical processing is obtained by multiple loading of the step gradient, either NaBr or conventional gradients.
    Type: Grant
    Filed: April 4, 1979
    Date of Patent: December 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Hepatitis B core antigen composition
    Patent number: 4234564
    Abstract: Compositions comprising HB.sub.s Ag and a physiologically acceptable medium are useful as diagnostic and immunologic agents.
    Type: Grant
    Filed: December 19, 1977
    Date of Patent: November 18, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William J. Miller, Edward H. Wasmuth
  • Isolation of hepatitis B e antigen
    Patent number: 4204989
    Abstract: Hepatitis B e antigen or hepatitis B e antibody are separated from human biological fluid by centrifugation in a density gradient and isolated in the 1.04-1.15 g/cc density region.
    Type: Grant
    Filed: December 13, 1978
    Date of Patent: May 27, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Hepatitis B antigen
    Patent number: 4186193
    Abstract: Hepatitis B surface antigen free of gradient-derived added cesium and potassium ions, for example the antigen in an aqueous solution of sodium bromide.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: January 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Isolation of HB.sub.s Ag
    Patent number: 4181713
    Abstract: High purity HB.sub.s Ag is injected into guinea pigs to stimulate formulation of HB.sub.s Ab-positive serum. Gamma globulins containing HB.sub.s Ab are separated from the serum and the globulin fraction containing HB.sub.s Ab is isolated and coupled to a Sepharose gel. HB.sub.s Ag from HB.sub.s Ag-positive plasma is adsorbed on the gel by formation of an HB.sub.s Ab-HB.sub.s Ag complex. HB.sub.s Ag is eluted from the column and dialysed.
    Type: Grant
    Filed: October 30, 1978
    Date of Patent: January 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Method for preparing hepatitis B immune globulin
    Patent number: 4174388
    Abstract: Hepatitis B immune globulin is prepared from individuals who exhibit an increase in hepatitis B surface antibody of at least 2,000 PHA units/ml following immunization with hepatitis B surface antigen.
    Type: Grant
    Filed: July 19, 1978
    Date of Patent: November 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Isolating hepatitis B Dane particles
    Patent number: 4129646
    Abstract: Biological fluid containing hepatitis B surface antigen is subjected to isopycnic banding with collection of fractions rich in Dane particles. The Dane particles are useful as diagnostic and immunologic agents.
    Type: Grant
    Filed: April 4, 1977
    Date of Patent: December 12, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Hepatitis B antigen
    Patent number: 4118477
    Abstract: An improved process for the preparation of hepatitis B antigen by subjecting biological fluid containing heptatitis B surface antigen to isopycanic banding wherein the step gradient is NaBr. Faster and more economical processing is obtained by multiple loading of the step gradient, either NaBr or conventional gradients.
    Type: Grant
    Filed: September 2, 1977
    Date of Patent: October 3, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Method of preparing hepatitis B core antigen
    Patent number: 4102996
    Abstract: HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: July 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, William J. Miller, Edward H. Wasmuth
  • Separation of trachoma agent from growth medium impurities
    Patent number: 4096035
    Abstract: Trachoma agent is separated from growth medium impurities by density gradient centrifugation in a sodium bromide solution.
    Type: Grant
    Filed: June 15, 1977
    Date of Patent: June 20, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Roy A. Machlowitz, Edward H. Wasmuth
  • Hepatitis B surface antigen
    Patent number: 4088748
    Abstract: Biological fluid containing hepatitis B surface antigen is concentrated using ammonium sulfate, and subjected to an isopycnic banding followed by rate zonal banding.
    Type: Grant
    Filed: May 4, 1977
    Date of Patent: May 9, 1978
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Separating antigen from residual common sensitizing protein
    Patent number: 4039657
    Abstract: Sensitizing plasma protein is dissociated from antigen-plasma protein complex by agitating at low temperature under controlled pH.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: August 2, 1977
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth
  • Process for isolating hepatitis B antigen
    Patent number: 4024243
    Abstract: An improved process for the preparation of hepatitis B antigen by subjecting plasma of hepatitis B donors to isopycanic banding wherein the step gradient is NaBr. Faster and more economical processing is obtained by multiple loading of the step gradient, either NaBr or conventional gradients.
    Type: Grant
    Filed: June 16, 1975
    Date of Patent: May 17, 1977
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Edward H. Wasmuth