Patents by Inventor Edward J. Bilsky

Edward J. Bilsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glucagon-like peptide-1 glycopeptides
    Patent number: 9234023
    Abstract: Methods and materials are provided for the production of glycosylated GLP-1 peptides that exhibit improved properties. The methods and materials of the present invention may be used for treatment of metabolic conditions, such as Syndrome X and diabetes.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: January 12, 2016
    Assignee: Biousian Biosystems, Inc.
    Inventors: Edward J. Bilsky, Robin Polt, Hanoch Senderowitz
  • Delta-Opioid Receptor Selective Analgesics
    Publication number: 20140249091
    Abstract: Methods and materials are provided for the production of glycosylated peptides that exhibit high affinity and specificity for delta opioid receptors. The methods and materials of the present invention may be used for treatment of conditions involving pain, such as acute pain and nociceptic pain, neuralgia and myalgia.
    Type: Application
    Filed: October 8, 2013
    Publication date: September 4, 2014
    Applicant: BIOUSIAN BIOSYSTEMS, INC.
    Inventors: Robin Polt, Edward J. Bilsky
  • Delta-opioid receptor selective analgesics
    Patent number: 8575309
    Abstract: Methods and materials are provided for the production of glycosylated peptides that exhibit high affinity and specificity for delta opioid receptors. The methods and materials of the present invention may be used for treatment of conditions involving pain, such as acute pain and nociceptic pain, neuralgia and myalgia.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: November 5, 2013
    Assignee: Biousian Biosystems, Inc.
    Inventors: Robin Polt, Edward J. Bilsky
  • DELTA-OPIOID RECEPTOR SELECTIVE ANALGESICS
    Publication number: 20120101043
    Abstract: Methods and materials are provided for the production of glycosylated peptides that exhibit high affinity and specificity for delta opioid receptors. The methods and materials of the present invention may be used for treatment of conditions involving pain, such as acute pain and nociceptic pain, neuralgia and myalgia.
    Type: Application
    Filed: December 8, 2009
    Publication date: April 26, 2012
    Applicant: BIOUSIAN BIOSYSTEM, INC.
    Inventors: Robin Polt, Edward J. Bilsky
  • Pyridomorphinans, pyridazinomorphinans and use thereof
    Patent number: 7951817
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: May 31, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, Southern Research Institute, University of New England College of Osteopathic Medicine, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • PYRIDOMORPHINANS, PYRIDAZINOMORPHINANS AND USE THEREOF
    Publication number: 20090239892
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Application
    Filed: March 19, 2009
    Publication date: September 24, 2009
    Applicants: Southern Research Institute, National Institute on Drug Abuse, National Institute of Health, University of New England College of Osteopathic Medicine, The Arizona Board of Reagents on behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • Pyridomorphinans, pyridazinomorphinans and use thereof
    Patent number: 7541364
    Abstract: Compounds represented by the formula: wherein R is C1-6 alkyl; C4-6 cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence to ? agonists.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: June 2, 2009
    Assignee: Southern Research Institute
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca
  • Pyridomorphinans, Pyridazinomorphinans and Use Thereof
    Publication number: 20080194568
    Abstract: Compounds represented by formula (I) wherein R is C1-6cycloalkylalkyl; or C3-6 alkenyl; R? is H or C1-6 alkyl; X is H or OH; Y is alkyl, cycloalkyl, aryl, heteroaryl or aroyl; and Z is CH or N; provided that X is H, when Z is CH and R is C4 cycloalkylalkyl or C4 alkenyl; prodrugs thereof; and pharmaceutically acceptable salts thereof are provided. Compounds of the above formula are useful as analgesics for treating pain; as immunomodulators, to modulate the behavioral effects of drugs of abuse and to modulate the development of tolerance and dependence of ? agonists.
    Type: Application
    Filed: August 27, 2004
    Publication date: August 14, 2008
    Applicants: Southern Research Institute, National Institute on Drugs Abuse, NIH, University of New England College of Osteopathic Medicine, The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Subramaniam Ananthan, Richard B. Rothman, Edward J. Bilsky, Frank Porreca