Patents by Inventor Edward J. Brnardic

Edward J. Brnardic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of checkpoint kinases
    Patent number: 7501435
    Abstract: The instant invention provides for compounds which comprise substituted triazoloquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: March 10, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Arrington, Edward J. Brnardic, Vadim Y. Dudkin, Mark E. Fraley, Shaei Y. Huang, Cheng Wang
  • Inhibitors of checkpoint kinases
    Patent number: 7485649
    Abstract: The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: February 3, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Brnardic, Mark E. Fraley, Robert M. Garbaccio
  • Inhibitors of Checkpoint Kinases
    Publication number: 20090023767
    Abstract: The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
    Type: Application
    Filed: December 29, 2006
    Publication date: January 22, 2009
    Inventors: Edward J. Brnardic, Mark E. Fraley
  • Inhibitors Of Checkpoint Kinases
    Publication number: 20080214594
    Abstract: The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
    Type: Application
    Filed: January 5, 2006
    Publication date: September 4, 2008
    Inventors: Edward J. Brnardic, Mark E. Fraley, Robert M. Garbaccio
  • Inhibitors of Checkpoint Kinases
    Publication number: 20080114016
    Abstract: The instant invention provides for compounds which comprise fused pyrazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by ad-ministering the compound to a patient in need of treatment of cancer.
    Type: Application
    Filed: January 5, 2006
    Publication date: May 15, 2008
    Inventors: Edward J. Brnardic, Mark E. Fraley, Robert M. Garbaccio, Justin T. Steen
  • Inhibitors of checkpoint kinases
    Publication number: 20070254879
    Abstract: The instant invention provides for compounds which comprise substituted triazoloquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
    Type: Application
    Filed: April 24, 2007
    Publication date: November 1, 2007
    Inventors: Kenneth L. Arrington, Edward J. Brnardic, Vadim Y. Dudkin, Mark E. Fraley, Shaei Y. Huang, Cheng Wang