Patents by Inventor Edward J. DELIKATNY

Edward J. DELIKATNY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosing and treating cancer
    Patent number: 11813338
    Abstract: The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (ChoK). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (ChoK) inhibitor or a ChoK inhibitor operably linked to a fluorescent dye. The composition is capable of diagnosing and/or treating cancer diseases associated with ChoK.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 14, 2023
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Edward J. Delikatny, Anatoliy V. Popov, Sean P. Arlauckas
  • In vivo detection of phospholipase activation
    Patent number: 11034994
    Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: June 15, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Edward J. Delikatny, Anatoliy V. Popov, Gang Zheng, Theresa Mawn
  • IN VIVO DETECTION OF PHOSPHOLIPASE ACTIVATION
    Publication number: 20180245129
    Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.
    Type: Application
    Filed: April 30, 2018
    Publication date: August 30, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Edward J. DELIKATNY, Anatoliy V. Popov, Gang Zheng, Theresa Mawn
  • DIAGNOSING AND TREATING CANCER
    Publication number: 20160220703
    Abstract: The invention relates to compositions and methods for diagnosing as well as treating cancer diseases associated with choline kinase (ChoK). Specifically, the invention relates to a composition comprising an intrinsically fluorescent choline kinase (ChoK) inhibitor or a ChoK inhibitor operably linked to a fluorescent dye. The composition is capable of diagnosing and/or treating cancer diseases associated with ChoK.
    Type: Application
    Filed: March 12, 2014
    Publication date: August 4, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Edward J. DELIKATNY, Anatoliy V. POPOV, Sean P. ARLAUCKAS