Patents by Inventor Edward J. Gragoe, Jr.

Edward J. Gragoe, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis
    Patent number: 4423063
    Abstract: 2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: ##STR1## where R is hydrogen or C.sub.1-4 alkyl; andL is a lipophilic group consisting essentially of ##STR2## where R' is (a) hydrogen; (b) C.sub.1-3 alkyl; (c) benzyl; (d) pyridyl C.sub.1-3 alkyl or (e) (3,4-dihydro-3-hydroxy-2H-1,5-benzodioxepin-3-yl) methyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted; or ##STR3## where R' has the same meaning as above; or a pharmaceutically acceptable salt thereof; useful in treating urinary tract, especially renal calcium oxalate lithiasis.
    Type: Grant
    Filed: March 5, 1982
    Date of Patent: December 27, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Clarence S. Rooney, Haydn W. R. Williams, Edward J. Gragoe, Jr., Arthur A. Patchett
  • 2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in treating hypertension and edema
    Patent number: 4123537
    Abstract: Certain substituted 4-aminomethyl-3-pyridinols and their pharmaceutically acceptacle acid addition salts wherein the pyridinol nucleus may be further substituted with 1 to 2 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents. These products may be prepared by halogenating an appropriately substituted pyridine salt.
    Type: Grant
    Filed: May 26, 1977
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Gerald E. Stokker, Edward J. Gragoe, Jr.