Patents by Inventor Edward J. Luber, Jr.

Edward J. Luber, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of the nicotinyl ester of 6-aminonicotinic acid
    Patent number: 4375545
    Abstract: 6-Aminonicotinic acid is reacted with an alkali carbonate selected from the group consisting of sodium carbonate and potassium carbonate. The reaction is carried out at elevated temperature and in dimethylformamide. The 6-aminonicotinic acid alkali salt so produced is reacted with 3-chloromethylpyridine hydrochloride. The reaction is carried out at elevated temperature and in dimethylformamide. The desired nicotinyl ester is thus produced.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: March 1, 1983
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr., William A. Somerville, F. Christopher Zusi
  • 1-(2-Acylaminophenyl)imidazoles
    Patent number: 4236015
    Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.5 is a cycloaliphatic, phenyl, substituted phenyl group bonded to the carbonyl carbon through a carbon-to-carbon linkage are intermediates for the preparation of 4-substituted imidazo[1,2-a]quinoxalines having anti-inflammatory, immunosuppressant and anti-fungal activity.
    Type: Grant
    Filed: May 7, 1979
    Date of Patent: November 25, 1980
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • Treatment of inflammatory disorders with 4-trifluoromethylimidazo[1,2-a]quinoxaline
    Patent number: 4229452
    Abstract: A method for treating inflammatory disorders in mammals which comprises administering to said mammals having an inflammatory disorder a therapeutically effective amount of 4-trifluoromethylimidazo[1,2-a]quinoxaline.
    Type: Grant
    Filed: July 12, 1979
    Date of Patent: October 21, 1980
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • 1-(2-Phenylureylene)imidazoles
    Patent number: 4225724
    Abstract: 2(1-imidazolyl)phenylureylene compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups are intermediates for the preparation of 4-substituted amino imidazo[1,2-a]quinoxalines having immunosuppressant activity.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: September 30, 1980
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • 4-Substituted imidazo [1,2-a]quinoxalines
    Patent number: 4200750
    Abstract: A 4-substituted imidazo [1,2-a]quinoxaline of formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is bonded to a ring carbon through a carbon-to-carbon linkage and is an aliphatic, cycloaliphatic, substituted phenyl, fused bicyclic aryl; or a monocyclic aryl substituted aliphatic group.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: April 29, 1980
    Assignee: Westwood Pharmaceuticals Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • Process for preparing 4-substituted imidazo[1,2-a]quinoxalines
    Patent number: 4198508
    Abstract: Preparation of 4-substituted imidazo[1,2-a]quinoxalines by cyclizing a compound of the formula: ##STR1## with phosphorous oxychloride wherein X.sup.2 is a group --R.sup.5 or --NHR.sup.2 where R.sup.5 and R.sup.2 are hydrogen or various organo groups.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: April 15, 1980
    Assignee: Westwood Pharmaceuticals Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • 4-Aminosubstituted imidazo(1,2-A)quinoxalines
    Patent number: 4197403
    Abstract: A 4-substituted imidazo[1,2-a]quinoxaline of formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic group.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: April 8, 1980
    Assignee: Westwood Pharmaceuticals Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • Method for treating fungal infection in mammals with imidazo [1,2-a]quinoxalines
    Patent number: 4191767
    Abstract: A method for treating a fungal infection in mammals which comprises administering to said mammals having a fungal infection a therapeutically effective amount of a 4-(substituted phenyl)imidazo[1,2-a]quinoxaline.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: March 4, 1980
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • Method for reducing immunological response
    Patent number: 4191766
    Abstract: A method for reducing the immunological response in mammals by the administration of certain substituted phenyl or substituted anilino imidazo[1,2-a]quinoxalines.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: March 4, 1980
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • 1-(2-Acylaminophenyl)imidazoles
    Patent number: 4172947
    Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.5 is hydrogen or an aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl or monocyclic aryl substituted aliphatic group bonded to the carbonyl carbon through a carbon-to-carbon linkage. The compounds are useful as intermediates in the preparation of 4-substituted imidazo[1,2-a]quinoxalines.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: October 30, 1979
    Assignee: Westwood Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
  • 1-(2-Phenylureylene)imidazoles
    Patent number: 4160097
    Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: July 3, 1979
    Assignee: Westwind Pharmaceuticals, Inc.
    Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.