Patents by Inventor Edward J. Miracco

Edward J. Miracco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR RNA MAPPING
    Publication number: 20230212645
    Abstract: Novel methods for identification and analysis of mRNA are provided herein. The methods may involve digestion and fingerprinting analysis.
    Type: Application
    Filed: June 29, 2022
    Publication date: July 6, 2023
    Applicant: ModernaTX, Inc.
    Inventors: David Marquardt, Nicholas J. Amato, Edward J. Miracco, Tao Jiang, Serenus Hua, Huijuan Li
  • RNA AFFINITY PURIFICATION
    Publication number: 20220290125
    Abstract: Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation. The methods may comprise contacting a nucleic acid preparation comprising messenger ribonucleic acid with an RNase III enzyme that is immobilized on a solid support and binds to double-stranded RNA contaminants.
    Type: Application
    Filed: June 2, 2022
    Publication date: September 15, 2022
    Applicant: ModernaTx, Inc.
    Inventor: Edward J. Miracco
  • RNA affinity purification
    Patent number: 11384352
    Abstract: Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation. The methods may comprise contacting a nucleic acid preparation comprising messenger ribonucleic acid with an RNase III enzyme that is immobilized on a solid support and binds to double-stranded RNA contaminants.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: July 12, 2022
    Assignee: ModernaTX, Inc.
    Inventor: Edward J. Miracco
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20220096522
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 31, 2022
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20220096521
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 31, 2022
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • High purity RNA compositions and methods for preparation thereof
    Patent number: 11202793
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: December 21, 2021
    Assignee: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • High purity RNA compositions and methods for preparation thereof
    Patent number: 10653712
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: May 19, 2020
    Assignee: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • RNA AFFINITY PURIFICATION
    Publication number: 20200071689
    Abstract: Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation. The methods may comprise contacting a nucleic acid preparation comprising messenger ribonucleic acid with an RNase III enzyme that is immobilized on a solid support and binds to double-stranded RNA contaminants.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 5, 2020
    Applicant: ModernaTX, Inc.
    Inventor: Edward J. Miracco
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20190247417
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20180363019
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: June 6, 2018
    Publication date: December 20, 2018
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora