Abstract: The present invention relates to compositions and methods for reducing the carriage of antibiotic resistance genes.

Abstract: Compositions and methods for altering tryptamine levels in a subject are provided. In general, the compositions comprise microorganisms.

Abstract: The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.

Abstract: Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with immune suppression, including infections and/or GvHD, for example, in HSCT subjects. The bacterial compositions disclosed herein are designed to exhibit one or more functional features that are useful for the treatment of such diseases and disorders.

Abstract: The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.

Abstract: Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with dysbiosis of a gastrointestinal tract. The bacterial compositions disclosed herein are designed to exhibit one or more functional features that are useful for the treatment of such diseases and disorders.

Abstract: Our client, Seres Therapeutics, has asked us to file a new provisional application related to bacterial compositions and the use of such compositions for the treatment of inflammatory bowel disease.

Abstract: Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with an inflammatory bowel disease.

Abstract: The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.

Abstract: The present invention relates to compositions and methods for reducing the carriage of antibiotic resistance genes.

Abstract: Compositions and methods for altering tryptamine levels in a subject are provided. In general, the compositions comprise microorganisms.

Abstract: An actuation system and method, the system including a tubular having a passage, and an assembly disposed with the tubular. The assembly includes a degradable restriction, the restriction only partially blocking the passage prior to being degraded. The assembly is configured to receive and prevent further movement of a restrictor through the tubular prior to the restriction being degraded. The assembly is further configured to release the restrictor when the restriction is degraded.

Abstract: An apparatus can include a conveyance device having a flow bore, an isolator forming a testing volume at least partially defined by an inner surface of a wellbore tubular, and one or more pressure sensors generating signals representative of a pressure in the testing volume while the conveyance device moves the isolator axially through the wellbore tubular. The isolator substantially isolates a testing fluid received from the flow bore in the testing volume from an adjacent bore of the wellbore tubular. A location of at least one flow path in the wellbore tubular is identified by estimating a pressure of the testing fluid in the testing volume. It is emphasized that this abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the general subject matter of the technical disclosure.

Abstract: In the present invention, there is a single seat pedestal for supporting two seats without further support comprising a tubular pyramid capped with a plate and supporting two arms at right angle to one another.

Abstract: In the present invention, there is a single seat pedestal for supporting two seats without further support comprising a tubular pyramid capped with a plate and supporting two arms at right angle to one another.

Abstract: A composite plug that can be used in fracturing has backup rings for the seal that are preferably made of a composite material. The backup rings are essentially connected segments that allow the connections to break when the plug is set and the cones are brought closer together. When the rings break to form gaps between segments in a specific ring, the adjacent ring has offset gaps so that as a whole there are no extrusion gaps that would allow the seal element to pass. The rings can be rotationally locked to each other initially at the adjacent segments that are formed when the plug is set to maintain their relative positions so that gaps between segments adjacent the seal are overlapped with segments from the adjacent ring. The segmenting backup rings can be used on one or on both sides of a sealing element.

Abstract: A downhole tool for performing a wellbore operation includes a perforating gun, a detector module connected to the perforating gun, wherein the detector module transmits a command in response to a signal, a signal generator configured to transmit the signal to the detector module, and a plug dropping mechanism located adjacent to the detector module, the plug dropping mechanism releasing an object upon receiving the command from the detector module. The perforating gun is fired, and the downhole tool is activated. A plug-mate positioned adjacent to the plug dropping mechanism receives the object. The plug-mate has a profile complementary to the object, and the plug-mate and the object cooperating to block flow along the wellbore. In another mode of operation, an actuation member actuates the plug-mate.

Abstract: A frac plug mandrel assembly has an inner core that permits flow that is surrounded by a thin wall tube that distributes compressive loading, such as that applied by the set sealing element to the core. The core is a cylindrically shaped insert for inside the tube and allows flow until a ball or plug is landed on a seat to close off the flow through the core. The core can have a star pattern with a series of radially extending segments from a solid hub or a cylindrical shape of a honeycomb or other porous structure that has the requisite strength to resist collapse from compressive loading of the set sealing element while still allowing sufficient flow area for fluid displacement.

Abstract: A device to be deployed downhole. The device includes a member including a metallic foam and a sealing material coupled to the metallic foam. The member attains a compressed shape when compressed to restrict fluid flow between regions downhole. The sealing material may be in, on or coated on the metallic foam member.

Abstract: An apparatus for use in a wellbore is disclosed. The apparatus includes a downhole tool coupled to a wireline for conveying the downhole tool into the wellbore and for providing a data communication between the downhole tool and a surface device. The downhole tool further includes a settable device, a setting tool for setting the settable device in the wellbore, a sensor that provide measurements relating to downhole parameter, and a controller for determining the downhole parameter from the measurements and in response thereto altering an operation parameter.