Patents by Inventor Edward J. Weinstein

Edward J. Weinstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genome editing of a locus using zinc-finger nucleases
    Patent number: 8771985
    Abstract: Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: July 8, 2014
    Assignees: Sangamo BioSciences, Inc., Sigma-Aldvich Co. LLC
    Inventors: Xiaoxia Cui, Gregory Davis, Philip D. Gregory, Michael C. Holmes, Edward J. Weinstein
  • Genome editing of a Rosa locus using zinc-finger nucleases
    Publication number: 20120017290
    Abstract: Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Application
    Filed: April 25, 2011
    Publication date: January 19, 2012
    Inventors: Xiaoxia Cui, Gregory Davis, Philip D. Gregory, Michael C. Holmes, Edward J. Weinstein
  • Differentially expressed genes involved in angiogenesis, the proteins encoded thereby, and methods of using the same
    Publication number: 20030232367
    Abstract: The invention relates generally to the identification of nucleic acids and their encoded polypeptides, particularly VCC1, whose expression is modulated in angiogenesis. These nucleic acids and proteins have not previously been identified as having a biological role in angiogenesis. The invention further relates to compounds that modulate VCC1 expression and/or activity. Methods of using these compounds for modulation of VCC-1 expression and for treatment of diseases associated with expression of VCC-1 are provided. Also included are methods of diagnosis of VCC1 associated angiogenic disorders.
    Type: Application
    Filed: April 11, 2003
    Publication date: December 18, 2003
    Inventors: Edward J. Weinstein, Richard Head, Richard Mazzarella, David Griggs