Abstract: Compounds of general formula (I): (Formula I)) wherein R1, Q, R3, R4, R5, R6, R7 and Ar1 are as defined herein are inhibitors of class I histone deacetylases and are of use in the treatment of lysosomal storage disorders, especially Niemann-Pick type C disease, as well as other lysosomal storage disorders, defective autophagy, accumulation of free cholesterol and mycobacterial diseases.

Abstract: A detection system includes a first sensor configured to send a first ultrasonic pulse toward an object in a blowout prevention system. The first ultrasonic pulse has a first parameter. The detection system also includes a second sensor spaced from the first sensor and configured to send a second ultrasonic pulse toward the object. The second ultrasonic pulse has a second parameter that is different from the first parameter of the first ultrasonic pulse. The first parameter and the second parameter are one of an amplitude, a frequency, a duration, an emission time, and an excitation code. The second sensor is further configured to receive the first ultrasonic pulse after the first ultrasonic pulse interacts with the object. The detection system is configured to determine that the first ultrasonic pulse received by the second sensor was sent by the first sensor.

Abstract: This disclosure features chemical entities (e.g., a compound that modulates (e.g., agonizes) Stimulator of Interferon Genes (STING), or a pharmaceutically acceptable salt, and/or hydrate, and/or coccrystal, and/or drug combination of the compound) that are useful, e.g., for treating a condition, disease or disorder in which a decrease or increase in STING activity (e.g., a decrease, e.g., a condition, disease or disorder associated with repressed or impaired STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Abstract: Systems and methods for facilitating product design by an electronic device are described. According to certain aspects, an electronic device may display one or more designable canvases of a user interface for editing the visual design of a product. The electronic device may display an extended workspace canvas adjacent to and at least partially surrounding the one or more designable canvases. The extended workspace canvas may be configured to display a plurality of design elements that can be reached directly from the one or more designable canvases for use. Each of the design elements may be configured to be selectively positioned within the one or more designable canvases. The electronic device may, in response to a surface change selection of the one or more designable canvases, maintain the displaying of the extended workspace canvas while the one or more designable canvases are in a transitioning state.

Abstract: Apparatus and methods for biasing power amplifiers are provided herein. In certain embodiments, a power amplifier includes a bipolar transistor having a base biased by a bias network having a reactance that controls an impedance at the transistor base to achieve substantially flat phase response over large dynamic power levels. For example, the bias network can have a frequency response, such as a high-pass or band-pass response, that reduces the impact of power level on phase distortion (AM/PM).

Abstract: The present specification describes a smart security management system for managing the flow of people through security checkpoints in order to optimize overall throughput and efficiency. In an embodiment, the system includes a centralized database which is connected to a plurality of security checkpoints and which uses benchmark response data generated by a specific type of screening devices for a set of individuals. In an embodiment, the response data gathered by similar types of screening devices located at security checkpoints is compared with the benchmark response data stored in a centralized database to provide faster security clearance to individuals.

Abstract: An ultra-wideband-based object identification method and system includes: transmitting, using a transmitter, an ultra wideband signal to an object; receiving, using a receiver, a reflected signal from the object; and determining, using a processor, an identity of the object based on the received reflected signal.

Abstract: The present specification discloses a high speed scanning system for scanning cargo carried by rail. The system uses of a two-dimensional X-ray sensor array with, in one embodiment, a cone-beam X-ray geometry. The pulse rate of X-ray source is modulated based on the speed of the moving cargo to allow a distance traveled by the cargo between X-ray pulses to be equal to the width of the detector, for a single energy source, and to half the width of the detector for a dual energy source. This ensures precise timing between the X-ray exposure and the speed of the passing object, and thus accurate scanning of cargo even at high speeds.

Abstract: The present specification discloses an X-ray scanning system with a non-rotating X-ray scanner that generates scanning data defining a tomographic X-ray image of the object and a processor executing programmatic instructions where the executing processor analyzes the scanning data to extract at least one parameter of the tomographic X-ray image and where the processor is configured to determine if the object comprises a liquid, sharp object, narcotic, currency, nuclear materials, cigarettes or fire-arms.

Abstract: The present application is directed toward cargo scanning systems having scanners, each arranged to scan a respective object and generate a set of scan data, processors arranged to process each set of scan data to determine whether it meets a predetermined threat condition, workstations, and data management system arranged to direct data that meets the threat condition to one of the workstations for analysis.

Abstract: Concepts for managing a supervised machine learning model of a set of documents are presented. A system obtains annotated versions of the documents, the documents being annotated by annotators. A conflict between a plurality of annotations of the annotated versions of the documents is identified. The machine learning model includes a set of entities and relations defining relationships between entities. The identified conflict is resolved by at least one of identifying the correct annotation between the conflicting options, splitting the annotated text into two separate entities or relations, generating a new entity at the same or a less specific hierarchical level as the entities or relation in conflict, and/or changing an annotation of the annotated version of the document.

Abstract: The present invention is a self-contained mobile inspection system and method and, more specifically, improved methods and systems for detecting materials concealed within a wide variety of receptacles and/or cargo containers. In particular, the present invention is an improved method and system with a novel boom structure that reduces the weight of the boom. The single, light-weight boom of the inspection system is relatively compact in a stowed configuration and has a low height and center of gravity lending to greater maneuverability.

Abstract: This disclosure features chemical entities (e.g., a compound that modulates (e.g., agonizes) Stimulator of Interferon Genes (STING), or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that are useful, e.g., for treating a condition, disease or disorder in which a decrease or increase in STING activity (e.g., a decrease, e.g., a condition, disease or disorder associated with repressed or impaired STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Abstract: Apparatus and methods for bias switching of power amplifiers are provided herein. In certain configurations, a power amplifier system includes a power amplifier that provides amplification to a radio frequency (RF) signal, a power management circuit that controls a voltage level of a supply voltage of the power amplifier, and a bias control circuit that biases the power amplifier. The power management circuit is operable in multiple supply control modes, such as an average power tracking (APT) mode and an envelope tracking (ET) mode. The bias control circuit is configured to switch a bias of the power amplifier based on the supply control mode of the power management circuit.

Abstract: An X-ray inspection system for scanning items is provided. The system includes: a stationary X-ray source extending around a rectangular scanning volume, and defining multiple source points from which X-rays can be directed through the scanning volume; an X-ray detector array also extending around the rectangular scanning volume and arranged to detect X-rays from the source points which have passed through the scanning volume; a conveyor arranged to convey the items through the scanning volume; and at least one processor for processing the detected X-rays to produce scanning images of the items.

Abstract: This disclosure features compounds of Formula I, or a pharmaceutically acceptable salt thereof: in which R1, R2, R3, and R4 are as defined herein. These compounds are modulators of NLRP3, which are useful, e.g., for treating a condition, disease or disorder in which a decrease in NLRP3 activity (e.g., a condition, disease or disorder associated with repressed or impaired NLRP3 signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Abstract: A dual energy based X-ray scanning system has a linear detector array with high and low energy detectors. A signal processing method is employed that accounts for varying angles at which the transmitted X-rays impinge upon the detectors and also the varying order in which the transmitted X-rays pass through the high and low energy detectors. This yields both high resolution in the generated images and better penetration performance.

Abstract: Circuits and methods related to radio-frequency (RF) architectures having carrier aggregation. In some implementations, a carrier aggregation (CA) architecture can include a duplexer configured to provide duplexing functionality for a first frequency band and a second frequency band with a common antenna. The CA architecture can further include a first amplification path and a second amplification path coupled to respective ports of the duplexer, each of the first amplification path and the second amplification path configured to amplify a signal in its respective frequency band, each amplification path including a transmit/receive (TX/RX) switch configured to provide time-division duplexing (TDD) functionality for the amplified signal and a received signal. In some implementations, the first frequency band includes a B39 band, and the second frequency band includes a B41 band.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g., a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Abstract: A portal for scanning a person walking through the portal, wherein the person is carrying at least one object on the person's body, the portal having first and second vertical sides connected at their tops by a horizontal side; a transceiver positioned on the horizontal side to propagate radiation downwards on the person and receive at least one of first, second and third scan data, wherein the first scan data corresponds to a front-view, the second scan data corresponds to a plan-view and the third scan data corresponds to a back-view of the person; and at least one processor associated with the transceiver to process at least one of the first, second and third scan data to determine a location and dielectric signature of the at least one object.