Abstract: Provided are compounds of the Formula (I): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

Abstract: A method for virtual fatigue testing includes reading a coarse-grid finite-element-model of a component from one or more libraries with a computer, and identifying static stress locations neighboring at least one of fasteners and non-fastener stress concentration regions in the component by a static analysis of a component intermediate-grid finite-element-model of the component, identifying hot spot locations in the component intermediate-grid finite-element-model by performing a fatigue screening on the component, generating details for the component intermediate-grid finite-element-model based on the hot spot locations, and predicting crack results by a deterministic durability-and-damage-tolerance analysis of the details for a component fine-grid finite-element-model of the component, calculating a crack margins for the component fine-grid finite-element-model by a probabilistic durability-and-damage-tolerance analysis of the crack results, and generating an output file that contains the final crack initia

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract: Systems and methods for surveying roofing structures are disclosed. The method may include controlling a drone to fly along a first flight path in a direction over roofing structure of a site. A primary set of images of a first set of regions of the roofing structure is captured via at least one imaging device of the drone maintained in a first fixed pose relative to the roofing structure. The drone is controlled to fly along a second flight path over the roofing structure; capturing a secondary set of images of a second set of regions of the roofing structure via the at least one imaging device maintained in a second fixed pose relative to the roofing structure; storing and processing the primary set of images and the secondary set of images via the computing system to identify issues in the roofing structure of the site.

Abstract: The disclosed technology generally relates to integrated circuit devices with wear out monitoring capability. An integrated circuit device includes a wear-out monitor device configured to record an indication of wear-out of a core circuit separated from the wear-out monitor device, wherein the indication is associated with localized diffusion of a diffusant within the wear-out monitor device in response to a wear-out stress that causes the wear-out of the core circuit.

Abstract: An insole (2) has a heel region (8), an arch region (6) and a forefoot region (4). A pod (10) comprising an encapsulated liquid is partially embedded in a foam layer in the heel region (8). The impact of foot strike can lead to large forces on joints in the body. The insole (2) with the pod (10) reduces the impact of foot strike and therefore can lessen the impact of steps on the body.

Abstract: There is described an apparatus for heating an aerosol generating material to generate an inhalable aerosol or gas. The apparatus includes a housing; a receptacle within the housing, the receptacle including one or more cavities, each cavity for containing an aerosol generating material; and a heating arrangement including one or more heater elements for heating aerosol generating material contained in the one or more cavities to generate an inhalable aerosol or gas. The one or more heater elements are located externally of the one or more cavities.

Abstract: A mobile autonomous agricultural system including a powered mobile unit for carrying agricultural equipment, and configured to move along rows of crops; at least one laser curtain sensor configured to project a laser curtain away from the mobile unit; a location module configured to monitor a location of the mobile unit relative to a row; a controller configured to control the travel of the mobile unit; a safety module configured to: receive a location signal from the location module related to the location of the mobile unit relative to a row, select a mode of operation to process the laser curtain in a predefined laser curtain pattern, based on the received location signal, each mode of operation corresponding to a different predefined laser curtain pattern, and to generate a safety output in response to determining that the laser curtain is interrupted within the laser curtain pattern.

Abstract: Described herein is a computer implemented method for automatically generating a design. The method includes receiving an input prompt for generating the design and generating a design outline based on the input prompt. The design outline includes a style descriptor for the design. The method further includes retrieving a design template based on the design outline. The design template includes a placeholder design element. The method further includes retrieving at least one design element for the placeholder element. The design is generated by populating the placeholder element with the design element.

Abstract: A device for providing respiratory gases comprises a blower configured to receive a first gas from a first gas flow path and generate a flow of a first gas provided through a first gases outlet of the blower; a second gas flow path configured to receive a flow of a second gas and provide the flow of the second gas through a second gases outlet; and a mixing chamber configured to receive a flow of the first gas from the first gases outlet and a flow of the second gas from the second gases outlet. The received gases are configured to mix in the mixing chamber to form a mixed gas. The received gases are configured to travel in a mixing flow direction in the mixing chamber towards a mixed gases inlet, wherein mixed gas exits the mixing chamber via the mixed gases inlet providing flow to a mixed gas flow path.

Abstract: A device, comprises a microphone and a communication interface configured to send to a premises automation control core audio input received via the microphone. The premises automation control core is configured to determine, based at least in part on the audio input, a premises automation context associated with the device and send to the device via the communication interface a context data indicating the determined context. The devices also comprises a visual display device, a physical input device, and a processor coupled to the visual display device and the communication interface. The processor is configured to receive the context data and cause the visual display device to provide a visual display associated with the context data.

Abstract: A mobile autonomous agricultural system comprises: a powered mobile unit for carrying agricultural equipment, and configured to move along rows of crops; an ultraviolet (UV) lighting panel for generating UV light; and a controller configured to control the travel of the mobile unit and operation of the UV lighting panel. The UV lighting panel comprises: a UV light source configured to generate UV light; and a plurality of shade elements arranged relative to the UV light source to direct the UV light in a primary illumination direction and to restrict emission of UV light from the UV lighting panel outside the primary illumination direction.

Abstract: An integrated chilling unit for above-counter installation in an aircraft galley. The integrated chilling unit includes a housing. The housing includes a top wall, a rear wall, a first side wall, a second side wall and a bottom wall. The integrated chilling unit also includes a door hingedly attached to the housing. An interior of the integrated chilling unit stores items for cooling. The housing includes a vacuum insulation structure, wherein the vacuum insulation structure comprises a vacuum insulation panel.

Abstract: A method of determining an arrangement for objects comprises obtaining first data representing a first arrangement of first objects in a scene; inputting the obtained first data into a trained machine learning model to determine a first cost value for the first arrangement. The first cost value is indicative of an extent to which the first arrangement differs from an optimum arrangement of the first objects according to a cost function that the machine learning model has been trained to provide. The method comprises determining a second arrangement for the first objects based on the first cost value.

Abstract: Articles including a substrate, a cover glass layer disposed over a top surface of the substrate, and an adhesive layer having a dynamic elastic modulus disposed between a bottom surface of the cover glass layer and the top surface of the substrate. The cover glass layer may have a thickness in the range of 1 micron to 200 microns. The dynamic elastic modulus of the adhesive layer may include a first elastic modulus in the range of 10 kPa to 1000 kPa measured at a stress frequency in the range of 0 Hertz to 5 Hertz and a temperature of 23 degrees C., and a second elastic modulus of 500 MPa or more measured at a stress frequency in the range of 10 Hertz to 1000 Hertz and a temperature of 23 degrees C. The adhesive layer may be optically transparent. The articles may be bendable electronic display devices or bendable electronic display device modules.

Abstract: A method and a device are disclosed including one or more plug-in or Add-on Software Components (ASC) provided by a Social Business Platform (SBP) to deliver configuration information for the integration of various applications, services, and functionality from other platforms in an integrated environment. Each ASC may deliver a particular type of configuration information usable to configure and/or integrate services from various platforms, the services including data tiles and data streams, storage and document management services, single0function applications, core applications like communication and task management services, and other application-specific add-ons. In various embodiments, the configuration information may be distributed as packages of one or more files, which describe the configuration to be applied to the integrated services.

Abstract: A computer implemented method for updating a scene representation model is disclosed. The method comprises obtaining a scene representation model representing a scene having one or more objects, the scene representation model being configured to predict a value of a physical property of one or more of the objects; obtaining a value of the physical property of at least one of the objects, the obtained value being derived from a physical contact of a robot with the at least one object; and updating the scene representation model based on the obtained value. An apparatus is also disclosed.

Abstract: A panel for use in the construction of a galley of an aircraft is disclosed. The panel comprises a frame, at least one insulation panel, and a cover panel. The frame comprises first and second opposing faces and one or more edge faces, and each edge face extends between the first and second faces. The cover panel has first and second opposing faces and each insulation panel has first and second opposing faces. One or more of the edge faces of the frame define a housing aperture and the frame is fixed to the cover panel with the first face of the frame adjacent to the second face of the cover panel.

Abstract: A panel for use in the construction of a galley of an aircraft is disclosed. The panel comprises a décor panel and at least one insulation panel. The décor panel has first and second opposing faces, and a housing aperture extends through the décor panel between the first and second faces. The housing aperture is of substantially the same configuration as the insulation panel or the insulation panels collectively when arranged side by side or when stacked. The housing aperture is configured to receive the at least one insulation panel, and the or each insulation panel is located in the housing aperture.