Patents by Inventor Edward John BERTACCINI

Edward John BERTACCINI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, compounds, and compositions for anesthesia
    Patent number: 10513494
    Abstract: Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of the compounds demonstrates favorable interactions with the GABA receptor type A. In addition, the compounds display reversible anesthetic effects in an animal model, with dose-response curves similar to those of known general anesthetics. GABA receptor-mediated effects are also demonstrated in a hippocampal brain slice preparation.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: December 24, 2019
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department Of Veterans Affairs
    Inventors: Edward John Bertaccini, Margaret Frances Davies
  • NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA
    Publication number: 20190106387
    Abstract: Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of the compounds demonstrates favorable interactions with the GABA receptor type A. In addition, the compounds display reversible anesthetic effects in an animal model, with dose-response curves similar to those of known general anesthetics. GABA receptor-mediated effects are also demonstrated in a hippocampal brain slice preparation.
    Type: Application
    Filed: December 5, 2018
    Publication date: April 11, 2019
    Inventors: Edward John BERTACCINI, Margaret Frances DAVIES
  • NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA
    Publication number: 20180022698
    Abstract: Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of the compounds demonstrates favorable interactions with the GABA receptor type A. In addition, the compounds display reversible anesthetic effects in an animal model, with dose-response curves similar to those of known general anesthetics. GABA receptor-mediated effects are also demonstrated in a hippocampal brain slice preparation.
    Type: Application
    Filed: October 16, 2015
    Publication date: January 25, 2018
    Inventors: Edward John BERTACCINI, Margaret Frances DAVIES