Abstract: The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein X1, R1, R2, R3, R4, and R5 are defined as set forth in the specification. The compounds are useful as potassium ion channel inhibitors.

Abstract: A robot and trailer system is disclosed. The robot can have a hitch that can attach to the trailer. The hitch can he remotely controlled to release and detach the trailer from the robot. The front panel of the trailer can be rounded, for example to enable dragging over obstacles with a reduced risk of snagging or catching on the obstacle.

Abstract: A standard for supporting a turbine rotor and a turbine shell includes a bearing block including a housing enclosing bearing surfaces engageable by the turbine rotor. Turbine shell-arm supports are located on opposite sides of the housing, the turbine shell-arm supports each having a horizontal and one or more vertical surfaces adapted to be engaged by support arms of a turbine shell enclosing at least a portion of the turbine. An internal cooling/heating circuit is arranged to simultaneously cool or heat the bearing block and the turbine shell-arm supports to thereby reduce differential thermal growth characteristics of the turbine rotor and turbine shell.

Abstract: A modular plug includes a plug housing having a mating end and a cable end and plug contacts at the mating end. The plug housing and the plug contacts are shaped and positioned to define an RJ-45 modular plug mating interface. The plug contacts are arranged into a first group and a second group with each of the plug contacts in the first group being electrically commoned to form a first power circuit and each of the plug contacts in the second group being electrically commoned to form a second power circuit. The first and second power circuits are terminated to different wires of a cable.

Abstract: A modular plug includes a plug housing, plug contacts held by the plug housing, and a stuffer cap coupled to the plug housing. The stuffer cap includes a cable channel configured to receive a cable therein. The stuffer cap includes an interior side that defines at least a portion of the cable channel. The modular plug includes a strain relief member held by the plug housing. The strain relief member includes a base and a spring beam extending from the base such that the spring beam is cantilevered from the base. The spring beam is configured to engage the cable and thereby pinch the cable between the interior side of the stuffer cap and the spring beam.

Abstract: A method of determining the authenticity of a document of value provided with a watermark pattern, the method comprising determining whether the watermark pattern exhibits a discontinuity.

Abstract: A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system and an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system.

Abstract: The disclosure is directed to a fuel distribution system for a consist. The fuel distribution system may have a first locomotive, a second locomotive, and a tender car. The fuel distribution system may also have at least one pump located onboard the tender car, and at least one fluid conduit attached to the at least one pump. The at least one fluid conduit may be configured to deliver gaseous fuel from the tender car to the first and second locomotives.

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant fusion polypeptides comprising mutations at positions 98, 171, 179, 180 or 181, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract: The invention relates to a novel multiwell array comprising a plurality of wells, the majority of which have a unique cross-sectional shape whereby each well within the array can be identified and so tracked whilst the contents of the array are investigated. The invention also concerns a computer and a programmable data storage device for use with the array and an imaging apparatus including any one or more of the afore features or aspects.

Abstract: A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank.

Abstract: A system comprises a package with top and bottom surfaces, a plurality of high-power transient voltage suppressors arranged within the package, and a robust lead frame. Each of the transient voltage suppressors has first and second major surfaces substantially perpendicular to the top and bottom surfaces of the package. The lead frame comprises leads connected to the major surfaces of the transient voltage suppressors. Each of the leads has a thickness greater than about 0.015 inches (or 0.381 mm) in a mounting portion, in order to dissipate heat from the transient voltage suppressors and to resist vibration-induced stress on the package.

Abstract: A hybrid method and system of treating wastewater with reduced energy usage is disclosed. The treatment system has a sorption system, an anaerobic digester that digests or converts at least a portion of the solids or sludge from the sorption system, and an aerobic treatment tank that partially reduces oxygen demand of a portion of the sludge from the sorption tank.

Abstract: In an embodiment, an apparatus includes a housing and a cover. The housing can include a surface to receive a terminal block to transmit power to an electrical component. A shroud to be inserted within the electrical component can extend away from the housing surface. The cover can have an end for hingedly attaching to the housing. The cover is pivotable relative to the housing between a closed position and an open position. In the closed position, the cover and the housing together form an enclosure for the terminal block.

Abstract: A compression ring for an engine is disclosed. The compression ring may have a cylindrical body having an outer surface, and a central opening formed within the cylindrical body and concentric with the outer surface of the cylindrical body. The cylindrical body may have a radial dimension from the central opening to the outer surface that is about 1.1 to 1.3 times as long as an axial dimension of the cylindrical body.

Abstract: The invention provides a multimer comprising at least a first and a second chain, the first chain comprising the polypeptide of SEQ ID NO:4, wherein the leucine at position 98 is substituted with an arginine; the proline at position 171 is substituted with glycine; and the alanine at position 180 is substituted with glutamic acid; a linker sequence comprising SEQ ID NO:31; and an Fe domain comprising SEQ NO:11; and a second chain comprising the polypeptide of SEQ ID NO:4, wherein the leucine at position 98 is substituted with an arginine; the proline at position 171 is substituted with glycine; and the alanine at position 180 is substituted with glutamic acid; a linker sequence comprising SEQ ID NO:31; and an Fe domain comprising SEQ ID NO:11, nucleic acids encoding the multimer, pharmaceutical compositions comprising the multimer and methods for treating metabolic disorders using such nucleic acids, multimers or pharmaceutical compositions.

Abstract: The present invention relates to an apparatus and method for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The integrated fusion cage and graft delivery device according to various embodiments delivers and disperses biologic material through a fusion cage to a disc space and, without withdrawal from the surgical site, may selectably detach the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area.

Abstract: A system for controlling a temperature a within an interior volume of a cargo trailer adapted to transport perishable goods is described herein. The system includes a fluid distribution assembly and a monitoring system operatively coupled to the fluid distribution assembly for selectively channeling a flow of cryogenic cooling fluid into the cargo trailer interior volume to facilitate adjusting a temperature within the interior volume. The monitoring system includes at least one sensor for sensing an environmental parameter of the cargo trailer, and a controller coupled to the sensor and to the fluid distribution assembly. The controller is configured to receive a monitoring signal indicative of the sensed environmental parameter, determine an environmental condition of the cargo trailer as a function of the environmental parameter, and provide a notification signal if the determined environmental condition is different than a predefined environmental condition.

Abstract: A bi-directional quick change tool-less lever and wedge actuated collet chuck, a system and/or a method provide symmetrical tool bit shank holding pressure before, during and after operation of a rotary-style power tool. The collet chuck is attached to and/or is integrated with high speed, variable speed and/or low speed rotary-style power tools, such as, for example, electrically driven rotary-style power tools and/or pneumatically-driven rotary-style power tools. The collet chuck provides tool-less automatic and/or tool-less manual tightening of the collet around a shank of an accessory for the rotary-style power tool. The collet chuck, the system and/or the method provide tool-less manual loosening of the collet for accessory replacement.

Abstract: The present system and method provides a more precise way to record food and beverage intake than traditional methods. The present disclosure provides custom software for use in mobile computing devices that include a digital camera. Photos captured by mobile digital devices are analyzed with image processing and comparisons to certain databases to allow a user to discretely record foods eaten. Specifically, the user captures images of the meal or snack before and after eating. The foods pictured are identified. Image processing software may identify the food or provide choices for the user. Once a food is identified and volume of the food is estimated, nutrient databases are used for calculating final portion sizes and nutrient totals.