Patents by Inventor Edward Johnstone

Edward Johnstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel beta-secretase and modulation of beta-secretase activity
    Publication number: 20060183160
    Abstract: The invention concerns a novel ?-secretase, a method of partially purifying this novel ?-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel ?-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.
    Type: Application
    Filed: April 12, 2006
    Publication date: August 17, 2006
    Applicant: Scios, Inc.
    Inventors: Ziyang Zhong, Barbara Cordell, Diana Quon, Yu-Wang Liu, Qiang Xu, Frauke Schimmoller, Paul Hyslop, Edward Johnstone, Sheila Little, Stephen Queener, Tinggui Yin