Patents by Inventor Edward Jolyon Griffen

Edward Jolyon Griffen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-heteroaryl thiazoles and their use as PI3K inhibitors
    Patent number: 7868188
    Abstract: The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: January 11, 2011
    Assignee: AstraZeneca AB
    Inventors: Malena Bengtsson, Joakim Larsson, Grigorios Nikitidis, Peter Storm, John Peter Bailey, Edward Jolyon Griffen, Jean-Claude Arnould, Thomas Geoffrey Colerick Bird
  • 2-BENZIMIDAZOLYL-6-MORPHOLINO-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
    Publication number: 20100022534
    Abstract: The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R1, R2, q, R3, r, R4, s, t, X1 and Q1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in a method for producing an anti-proliferative effect in a warm blooded animal such as man.
    Type: Application
    Filed: September 12, 2007
    Publication date: January 28, 2010
    Applicant: AstraZeneca
    Inventors: Sam Butterworth, Edward Jolyon Griffen, Martin Pass
  • 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
    Publication number: 20090325954
    Abstract: The invention concerns pyrimidine derivatives of Formula (I), wherein each of p, R1, R2, q, R3, r, R4, X1 and Q1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in a method for producing an anti-proliferative effect in a warm blooded animal such as man.
    Type: Application
    Filed: September 12, 2007
    Publication date: December 31, 2009
    Inventors: Sam Butterworth, Edward Jolyon Griffen, Martin Pass
  • Indole Derivatives
    Publication number: 20090306126
    Abstract: The invention concerns indole derivatives of Formula I or pharmaceutically-acceptable salts thereof, wherein each of Ring A, m, R1, R2, n, R3 and G1 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.
    Type: Application
    Filed: May 18, 2007
    Publication date: December 10, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Kevin Michael Foote, Edward Jolyon Griffen
  • PYRIMIDINE DERIVATIVES
    Publication number: 20090270390
    Abstract: The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R1, R2, q, R3, r, R4, X1 and Q1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in a method for producing an anti-proliferative effect in a warm blooded animal such as man.
    Type: Application
    Filed: September 12, 2007
    Publication date: October 29, 2009
    Applicant: AstraZeneca
    Inventors: Sam Butterworth, Edward Jolyon Griffen, Martin Pass
  • 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS
    Publication number: 20090233926
    Abstract: The invention concerns pyrimidine derivatives of Formula (I), wherein each of p, R1, R2, q, R3, r, R4, X1 and Q1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in a method for producing an anti-proliferative effect in a warm blooded animal such as man.
    Type: Application
    Filed: September 12, 2007
    Publication date: September 17, 2009
    Applicant: AstraZeneca
    Inventors: Sam Butterworth, Edward Jolyon Griffen, Martin Pass
  • THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS
    Publication number: 20090076009
    Abstract: The invention concerns thiazole derivatives of Formula I or pharmaceutically-acceptable salts thereof, wherein each of R, Ring A, m, R1, R2 and R3 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.
    Type: Application
    Filed: May 2, 2007
    Publication date: March 19, 2009
    Inventors: Jean-Claude (Retired) Arnould, Kevin Michael Foote, Edward Jolyon Griffen
  • 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors
    Publication number: 20080132502
    Abstract: The invention provides thiazole derivatives of formula (I), or pharmaceutically acceptable salts thereof in which Ring A, R1, R2 and R3 are as defined in the specification; a processes for their preparation; pharmaceutical compositions containing them; and their use in therapy, for example in the treatment of disease mediated by a PI3K enzyme and/or a mTOR kinase.
    Type: Application
    Filed: November 7, 2005
    Publication date: June 5, 2008
    Inventors: Malena Bengtsson, Joakim Larsson, Grigorios Nikitidis, Peter Storm, John Peter Bailey, Edward Jolyon Griffen, Jean-Claude Arnould, Thomas Geoffrey Colerick Bird