Abstract: A system, method, and apparatus for an athlete to variably control the flexibility and stiffness parameters of a piece of athletic equipment to select a desired performance characteristic of the equipment based on the stiffness parameter. According to certain embodiments discussed herein, an item of sporting equipment may be embedded, impregnated, lined, or encased using nitinol components, wherein the nitinol components may themselves be treated using a specific method in order to achieve the desired transformation results, as described below.

Abstract: The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered intra-articularly as a sustained release formulation. The present invention also provides sustained release formulations in the form of a hydrogel for administering polypeptides that are covalently attached to a polymer, e.g., PEG.

Abstract: A system for adjusting physical properties of a ski or snowboard, through use of one or more specially shaped components applied upon or embedded within the ski or snowboard, wherein the components may be comprised of a thermally responsive material that includes nitinol, and wherein the nitinol components may themselves be treated using a specific method in order to achieve desired transformation results that adjust stiffness, rocker, and in some cases camber angle of a ski.

Abstract: The apparatus, systems and methods disclosed herein generally relate to the surgical repair or alteration of bone. More particularly, certain of the disclosed apparatus, systems and methods of the present disclosure relate to the use of a directionally-reinforced composite material to emulate anisotropic structural characteristics of an original anatomic trabecular structure. The directionally-reinforced composite material may generally include a scaffold set in a composite matrix, wherein the scaffold determines the anisotropic structural characteristics of the materials. In some of the embodiments, a scaffold may include at least a first plurality of struts which are generally aligned in a first direction and a second plurality of struts aligned in a second direction.

Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.

Abstract: The present invention provides formulations for the treatment of fibrotic diseases and disorders. In some embodiments, the formulation comprises a microparticle that includes an antifibrotic.

Abstract: A system, method, and apparatus for an athlete to variably control the flexibility and stiffness parameters of a piece of athletic equipment to select a desired performance characteristic of the equipment based on the stiffness parameter. According to certain embodiments discussed herein, an item of sporting equipment may be embedded, impregnated, lined, or encased using nitinol components, wherein the nitinol components may themselves be treated using a specific method in order to achieve the desired transformation results, as described below.

Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.

Abstract: A system, method, and apparatus for an athlete to variably control the flexibility and stiffness parameters of a piece of athletic equipment to select a desired performance characteristic of the equipment based on the stiffness parameter. According to certain embodiments discussed herein, an item of sporting equipment may be embedded, impregnated, lined, or encased using nitinol components, wherein the nitinol components may themselves be treated using a specific method in order to achieve the desired transformation results, as described below.

Abstract: A system, method and apparatus for a digitally Controlled Variable Stiffness item of athletic equipment, such as a Ski, Snowboard, and Boots. A core of thermally responsive metal alloy, such as Nitinol is disposed within the athletic equipment. A thermal control module and controller permit the athlete to program the athletic equipment to a desired stiffness parameter. The controller may include an app operable via a mobile computing device in communication with the thermal control module.

Abstract: A system, method, and apparatus for an athlete to variably control the flexibility and stiffness parameters of a piece of athletic equipment to select a desired performance characteristic of the equipment based on the stiffness parameter. According to certain embodiments discussed herein, an item of sporting equipment may be embedded, impregnated, lined, or encased using nitinol components, wherein the nitinol components may themselves be treated using a specific method in order to achieve the desired transformation results, as described below.

Abstract: The apparatus, systems and methods disclosed herein generally relate to the surgical repair or alteration of bone. More particularly, certain of the disclosed apparatus, systems and methods of the present disclosure relate to the use of a directionally-reinforced composite material to emulate anisotropic structural characteristics of an original anatomic trabecular structure. The directionally-reinforced composite material may generally include a scaffold set in a composite matrix, wherein the scaffold determines the anisotropic structural characteristics of the materials. In some of the embodiments, a scaffold may include at least a first plurality of struts which are generally aligned in a first direction and a second plurality of struts aligned in a second direction.

Abstract: A system, method and apparatus for a digitally Controlled Variable Stiffness item of athletic equipment, such as a Ski, Snowboard, and Boots. A core of thermally responsive metal alloy, such as Nitinol is disposed within the athletic equipment. A thermal control module and controller permit the athlete to program the athletic equipment to a desired stiffness parameter. The controller may include an app operable via a mobile computing device in communication with the thermal control module.

Abstract: A system, method and apparatus for a digitally Controlled Variable Stiffness item of athletic equipment, such as a Ski, Snowboard, and Boots. A core of thermally responsive metal alloy, such as Nitinol is disposed within the athletic equipment. A thermal control module and controller permit the athlete to program the athletic equipment to a desired stiffness parameter. The controller may include an app operable via a mobile computing device in communication with the thermal control module.

Abstract: A system, method and apparatus for a digitally Controlled Variable Stiffness item of athletic equipment, such as a Ski, Snowboard, and Boots. A core of thermally responsive metal alloy, such as Nitinol is disposed within the athletic equipment. A thermal control module and controller permit the athlete to program the athletic equipment to a desired stiffness parameter. The controller may include an app operable via a mobile computing device in communication with the thermal control module.