Patents by Inventor Edward K. W. Wat

Edward K. W. Wat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
    Patent number: 5530124
    Abstract: This invention provides improved synthetic processes for the preparation of hydroxy-protected cyclic urea compounds of Formula (IX), ##STR1## which are useful as intermediates for the preparation of cyclic urea human immunodeficiency virus (HIV) protease inhibitors, from N-protected aminoaldehydes. The processes of the present invention provide high yields, can be conducted on multikilogram scale, and eliminate the need for chromatographic purification of intermediates or final product.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: June 25, 1996
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Lilian A. Radesca, Gregory D. Harris, Edward K. W. Wat, Robert E. Waltermire
  • Preparation of N-cyanoimidate herbicide intermediates
    Patent number: 4287343
    Abstract: Certain N-cyanoimidates are prepared by (a) contacting a propendimidate dihydrohalide salt with two equivalents of a base to produce a bisimidate; (b) contacting the bisimidate with cyanogen chloride to produce a mixture of N-cyanoimidate and a monohydrohalide bisimidate salt; (c) isolating the N-cyanoimidate. The N-cyanoimidate may, by heating, be converted to a pyrimidine, useful as a herbicide intermediate.
    Type: Grant
    Filed: October 4, 1979
    Date of Patent: September 1, 1981
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Edward K. W. Wat