Patents by Inventor Edward Kaftan

Edward Kaftan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF IDENTIFYING MODULATORS OF HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS
    Publication number: 20090029366
    Abstract: Methods, including high-throughput methods, for identifying modulators of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
    Type: Application
    Filed: March 27, 2008
    Publication date: January 29, 2009
    Applicant: Wyeth
    Inventors: Dmytro Vasylyev, Qiang Lu, Mark Bowlby, Edward Kaftan, Qin Shan
  • ASSAY SYSTEMS AND METHODS FOR DETECTING MOLECULES THAT INTERACT WITH SK2 CHANNELS
    Publication number: 20080268439
    Abstract: The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.
    Type: Application
    Filed: April 25, 2007
    Publication date: October 30, 2008
    Inventors: Edward Kaftan, Adrienne Elizabeth Dubin, Sandra R. Chaplan
  • Method for identifying modulators of NAion channels
    Patent number: 7195879
    Abstract: The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: March 27, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Adrienne Dubin, Sandra Chaplan, Sean Brown, Edward Kaftan
  • Assay systems and methods for detecting molecules that interact with SK2 channels
    Publication number: 20050250090
    Abstract: The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.
    Type: Application
    Filed: October 28, 2004
    Publication date: November 10, 2005
    Inventors: Edward Kaftan, Adrienne Dubin, Sandra Chaplan
  • Method for identifying modulators of ion channels
    Publication number: 20030194751
    Abstract: The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Nav1.3 and/or Nav1.7.
    Type: Application
    Filed: April 12, 2002
    Publication date: October 16, 2003
    Inventors: Adrienne Dubin, Sandra Chaplan, Sean Brown, Edward Kaftan