Patents by Inventor Edward Karol Dziadulewicz

Edward Karol Dziadulewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinazolinones as vanilloid antagonists
    Patent number: 9102653
    Abstract: The present specification relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: August 11, 2015
    Assignee: NOVARTIS AG
    Inventors: Timothy John Ritchie, Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Terance William Hart
  • QUINAZOLINONE DERIVATIVES USEFUL AS VANILLOID ANTAGONISTS
    Publication number: 20140315932
    Abstract: The present specification relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Applicant: NOVARTIS AG
    Inventors: Timothy John RITCHIE, Andrew James CULSHAW, Christopher Thomas BRAIN, Edward Karol DZIADULEWICZ, Terance William HART
  • Quinazolinone derivatives useful as vanilloid antagonists
    Patent number: 8809528
    Abstract: The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: August 19, 2014
    Assignee: Novartis AG
    Inventors: Timothy John Ritchie, Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Terance William Hart
  • QUINAZOLINONE DERIVATIVES USEFUL AS VANILLOID ANTAGONISTS
    Publication number: 20120184571
    Abstract: The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
    Type: Application
    Filed: March 29, 2012
    Publication date: July 19, 2012
    Inventors: Timothy John RITCHIE, Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Terance William Hart
  • Quinazolinone derivatives useful as vanilloid antagonists
    Patent number: 8211902
    Abstract: The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: July 3, 2012
    Assignee: Novartis AG
    Inventors: Timothy John Ritchie, Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Terance William Hart
  • QUINAZOLINONE DERIVATIVES USEFUL AS VANILLOID ANTAGONISTS
    Publication number: 20110195983
    Abstract: The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
    Type: Application
    Filed: April 19, 2011
    Publication date: August 11, 2011
    Inventors: Timothy John Ritchie, Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Terance William Hart
  • Chromone derivatives useful as antagonists of VR1 receptors
    Patent number: 7732435
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: June 8, 2010
    Assignee: Novartis AG
    Inventors: Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Lee Edwards, Terance William Hart, Timothy John Ritchie
  • Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists
    Publication number: 20090082365
    Abstract: The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6, R7 and R8 are as defined in the specification and in the claims, in free form or in salt form, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.
    Type: Application
    Filed: December 6, 2006
    Publication date: March 26, 2009
    Inventors: Gurdip Bhalay, Andrew James Culshaw, Edward Karol Dziadulewicz, Christopher Thomas Brain, Timothy John Ritchie, David Beattie, Kamlesh Jagdis Bala, Alice Brewer, Glyn Hughes
  • Quinazolinone Derivatives as Vanilloid Antagonists
    Publication number: 20080318940
    Abstract: The invention relates to quinazolinone compounds of the formula wherein the R groups are defined in the specification, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.
    Type: Application
    Filed: December 6, 2006
    Publication date: December 25, 2008
    Inventors: Edward Karol Dziadulewicz, Christopher Thomas Brain, Timothy John Ritchie, Andrew James Culshaw
  • Chromone Derivatives Useful as Antagonists of Vr1 Receptors
    Publication number: 20080312316
    Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Application
    Filed: December 5, 2006
    Publication date: December 18, 2008
    Inventors: Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Lee Edwards, Terance William Hart, Timothy John Ritchie
  • QUINAZOLINONE DERIVATIVES USEFUL AS ANTI-HYPERALGESIC AGENTS
    Publication number: 20080293939
    Abstract: The present invention relates to quinazolinones of formula (I) wherein R1 is hal; a); b); or c); X is N or CR8; R2 is hal; nitro; C1-C6alkylcarbonyl; C1-C6alkyl or C3-C6cycloalkyl; R3 is C1-C6alkyl; C1-C6alkoxy or amino; and wherein the further radicals have the meanings as defined in the specification, which compounds exhibit human vanilloid antagonistic activity; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: December 4, 2007
    Publication date: November 27, 2008
    Inventors: Andrew James Culshaw, Edward Karol Dziadulewicz, Allan Hallett, Terance William Hart
  • Quinazolinone Derivatives Useful as Vanilloid Antagonists
    Publication number: 20080194595
    Abstract: The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.
    Type: Application
    Filed: June 8, 2005
    Publication date: August 14, 2008
    Inventors: Timothy John Ritchie, Andrew James Culshaw, Christopher Thomas Brain, Edward Karol Dziadulewicz, Terance William Hart
  • Chromone Derivatives Useful as Vanilloid Antagonists
    Publication number: 20080114056
    Abstract: The present invention relates to the use of a chromone compound of the formula wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid antagonist.
    Type: Application
    Filed: June 8, 2005
    Publication date: May 15, 2008
    Inventors: Timothy John Ritchie, Andrew James Culshaw, Terance William Hart, Christopher Thomas Brain, Edward Karol Dziadulewicz
  • Bradykinin receptor antagonists
    Patent number: 6958331
    Abstract: The invention relates to sulfonyl amine derivatives of formula IA wherein R5A, X1, X2, R9 and R10 are as defined herein, which derivatives are useful as bradykinin B1 receptor antagonists.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: October 25, 2005
    Assignee: Novartis AG
    Inventors: Christopher Thomas Brain, William Cantrell, Andrew James Culshaw, Edward Karol Dziadulewicz, Terance William Hart, Timothy John Ritchie, Liladhar Waykole
  • Naphthalene derivatives
    Publication number: 20040053890
    Abstract: The present invention relates to novel naphthalene derivatives of formula (I), wherein R1, R2, R3 and X are as defined in the description, and preparation thereof. The compounds of formula (I) are useful as pharmaceuticals.
    Type: Application
    Filed: May 19, 2003
    Publication date: March 18, 2004
    Inventors: Christopher Thomas Brain, Andrew James Culshaw, Edward Karol Dziadulewicz, Ulrich Schopfer