Patents by Inventor Edward Karst

Edward Karst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190192855
    Abstract: Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.
    Type: Application
    Filed: December 21, 2018
    Publication date: June 27, 2019
    Inventors: Rupinder Bharmi, Stuart Rosenberg, Ryan Rooke, Edward Karst, Taraneh Ghaffari Farazi
  • Patent number: 10322290
    Abstract: The present disclosure provides systems and methods for integrating cardiac resynchronization therapy (CRT) and temporary induced dyssynchrony (TID) therapy. An implantable cardiac device includes one or more pulse generators coupled to a plurality of electrodes, and a controller communicatively coupled to the one or more pulse generators and configured to cause the one or more pulse generators to apply a combination of CRT and TID therapy to a patient's heart via the plurality of electrodes in accordance with at least one protocol.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: June 18, 2019
    Assignee: Pacesetter, Inc.
    Inventors: Yelena Nabutovsky, Jennifer Rhude, Edward Karst, Taraneh G. Farazi
  • Patent number: 10321292
    Abstract: Example electronic devices, including but not limited to implantable medical devices, and methods employing dynamic announcing for creation of wireless communication connections are disclosed herein. In an example, an electronic device includes a wireless communication interface to transmit announcement signals for creating a wireless communication connection with the external device. The electronic device also includes a sensor to detect a characteristic of an environment external to the electronic device, and a control circuit including an announcement timing control module to dynamically control timing of the announcement signals based on the detected characteristic.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: June 11, 2019
    Assignee: Pacesetter, Inc.
    Inventors: Timothy Pflugh, Fujian Qu, Benjamin Coppola, Edward Karst, Lisa P. Weinberg, Xing Pei, Yongjian Wu
  • Patent number: 10315034
    Abstract: The present disclosure provides a spinal cord stimulation (SCS) system. The system includes at least one SCS lead including a lead body, at least one distal electrode located at a distal end of the lead body, the at least one distal electrode configured to apply electrical stimulation to a stimulation target of a patient, and a pain reduction assembly coupled to the lead body and configured to reduce post-operation pain at an incision site associated with implantation of the at least one SCS lead. The system further includes a pulse generator coupled to the at least one SCS lead and configured to control electrical stimulation delivered to the patient via the at least one SCS lead.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: June 11, 2019
    Assignee: PACESETTER, INC.
    Inventors: Wenbo Hou, Alexander Kent, Edward Karst, Gene A. Bornzin, Riddhi Shah, Caroline Jordan, Yelena Nabutovsky
  • Patent number: 10201705
    Abstract: Described herein are methods, devices, and systems for treating human anemia. The methods, devices, and systems generally include monitoring a patient's hemoglobin level and at least one of autonomic balance and inflammatory state to determine the etiology of the anemic state, modulating at least one of a sympathetic or parasympathetic nerve based on the cause of the anemia, monitoring for changes in the patient's cardiac activity and state of inflammation, and hemoglobin level. An external neurostimulation system is describes, and well as a chronic implantable system. A method for treating a patient for anemia in conjunction with a renal denervation ablation catheter is also disclosed.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 12, 2019
    Assignee: Pacesetter, Inc.
    Inventors: Rupinder Bharmi, Stuart Rosenberg, Ryan Rooke, Edward Karst, Taraneh Ghaffari Farazi
  • Patent number: 10179243
    Abstract: The present disclosure provides systems and methods for providing temporary induced dyssynchrony (TID) therapy to patients with atrial tachycardia. An implantable cardiac device includes a pulse generator coupled to a plurality of electrodes, and a controller communicatively coupled to the pulse generator and configured to cause the pulse generator to apply TID therapy to a patient's heart via the plurality of electrodes, determine that the patient's heart is experiencing atrial tachycardia, and adjust at least one parameter of the TID therapy based on the determination.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: January 15, 2019
    Assignee: Pacesetter, Inc.
    Inventors: Yelena Nabutovsky, Jennifer Rhude, Edward Karst, Taraneh G. Farazi
  • Publication number: 20180361147
    Abstract: The present disclosure describes systems and methods for providing temporary induced dyssynchrony (TID) therapy. An implantable cardiac device includes a pulse generator coupled to a plurality of electrodes, and a controller communicatively coupled to the pulse generator. The controller is configured to receive a signal and determine whether to cause the pulse generator to apply TID therapy to a patient's heart based at least in part upon the received signal.
    Type: Application
    Filed: June 20, 2017
    Publication date: December 20, 2018
    Inventors: Edward Karst, Yelena Nabutovsky, Jennifer Rhude, Taraneh G. Farazi
  • Publication number: 20180361166
    Abstract: The present disclosure provides systems and methods for integrating cardiac resynchronization therapy (CRT) and temporary induced dyssynchrony (TID) therapy.
    Type: Application
    Filed: June 20, 2017
    Publication date: December 20, 2018
    Inventors: Yelena Nabutovsky, Jennifer Rhude, Edward Karst, Taraneh G. Farazi
  • Publication number: 20180361156
    Abstract: The present disclosure provides systems and methods for providing temporary induced dyssynchrony (TID) therapy to patients with atrial tachycardia. An implantable cardiac device includes a pulse generator coupled to a plurality of electrodes, and a controller communicatively coupled to the pulse generator and configured to cause the pulse generator to apply TID therapy to a patient's heart via the plurality of electrodes, determine that the patient's heart is experiencing atrial tachycardia, and adjust at least one parameter of the TID therapy based on the determination.
    Type: Application
    Filed: June 20, 2017
    Publication date: December 20, 2018
    Inventors: Yelena Nabutovsky, Jennifer Rhude, Edward Karst, Taraneh G. Farazi
  • Patent number: 10099057
    Abstract: Systems and methods are provided for determining a system response for a neuronal region of interest (ROI). The method comprises positioning an electrode proximate to the neuronal ROI. The electrode is electrically coupled to a neurostimulation (NS) system. The system delivers, from the NS system, a stimulation waveform from the electrode based on NS parameters. The system further programs one or more processors for: measuring an evoked potential waveform resulting from the stimulation waveform; comparing at least one excitation pulse within the stimulation waveform to the evoked potential waveform to obtain a candidate response function; repeating the delivering, measuring and comparing operations to obtain a collection of candidate response functions; and identifying a neuronal system response for the neuronal ROI based on the collection of candidate response functions.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: October 16, 2018
    Assignee: Pacesetter, Inc.
    Inventors: Alexander Kent, Gene A. Bornzin, Edward Karst
  • Publication number: 20180236237
    Abstract: The present disclosure provides a grip sensor for quantifying pain experienced by a patient during spinal cord stimulation (SCS). The grip sensor includes an electronics enclosure, an annular outer shell substantially surrounding the electronics enclosure and sized to be held by the patient, a pressure sensor embedded in the outer shell and communicatively coupled to the electronics enclosure, the pressure sensor configured to measure a grip strength of the patient as SCS is applied to the patient, and a plurality of galvanic skin response sensors communicatively coupled to the electronics enclosure and configured to measure an electrical impedance of the skin of the patient as SCS is applied to the patient.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 23, 2018
    Inventors: Alexander Kent, Edward Karst, Gene A. Bornzin
  • Publication number: 20180200423
    Abstract: A system for supplying power transcutaneously to an implantable device implanted within a subject is provided. The system includes an external connector including one of a microneedle array and a microwire holder. The system further includes a power cable electrically coupled to the external connector and configured to supply power to the one of the microneedle array and the microwire holder, and an internal connector configured to be implanted within the subject and electrically coupled to the implantable device, the internal connector including the other of the microneedle array and the microwire holder. The microneedle array includes a plurality of electrically conductive microneedles, the microwire holder includes a plurality of electrical contacts, and the microwire holder is configured to engage the microneedle array such that the plurality of electrically conductive microneedles extend through the skin of the subject and electrically couple to the plurality of electrical contacts.
    Type: Application
    Filed: January 18, 2018
    Publication date: July 19, 2018
    Inventors: Rahul Agarwal, Gene Bornzin, Edward Karst
  • Patent number: 10004900
    Abstract: The present disclosure provides systems and methods for correlating measurement in neurostimulation systems. A neurostimulation system includes a first sensor configured to acquire movement measurements for a subject, a second sensor configured to acquire neural measurements for the subject, and a computing device communicatively coupled to the first and second sensors. The computing device is configured to receive a movement signal from the first sensor, and receive a neural signal from the second sensor, wherein one of the movement signal and the neural signal is a trigger signal and the other of the movement signal and the neural signal is a signal of interest. The computing device is further configured to detect at least one trigger event in the trigger signal, and use the signal of interest based on the at least one trigger event.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 26, 2018
    Assignee: Pacesetter, Inc.
    Inventors: Alexander Kent, Gene Bornzin, Edward Karst
  • Patent number: 9981131
    Abstract: The present disclosure provides a grip sensor for quantifying pain experienced by a patient during spinal cord stimulation (SCS). The grip sensor includes an electronics enclosure, an annular outer shell substantially surrounding the electronics enclosure and sized to be held by the patient, a pressure sensor embedded in the outer shell and communicatively coupled to the electronics enclosure, the pressure sensor configured to measure a grip strength of the patient as SCS is applied to the patient, and a plurality of galvanic skin response sensors communicatively coupled to the electronics enclosure and configured to measure an electrical impedance of the skin of the patient as SCS is applied to the patient.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: May 29, 2018
    Assignee: Pacesetter, Inc.
    Inventors: Alexander Kent, Edward Karst, Gene A. Bornzin
  • Publication number: 20180140843
    Abstract: Systems and methods are provided for determining a system response for a neuronal region of interest (ROI). The method comprises positioning an electrode proximate to the neuronal ROI. The electrode is electrically coupled to a neurostimulation (NS) system. The system delivers, from the NS system, a stimulation waveform from the electrode based on NS parameters. The system further programs one or more processors for: measuring an evoked potential waveform resulting from the stimulation waveform; comparing at least one excitation pulse within the stimulation waveform to the evoked potential waveform to obtain a candidate response function; repeating the delivering, measuring and comparing operations to obtain a collection of candidate response functions; and identifying a neuronal system response for the neuronal ROI based on the collection of candidate response functions.
    Type: Application
    Filed: November 18, 2016
    Publication date: May 24, 2018
    Inventors: Alexander Kent, Gene A. Bornzin, Edward Karst
  • Patent number: 9907486
    Abstract: Example electronic devices, including but not limited to implantable medical devices, and methods employing dynamic announcing for creation of wireless communication connections are disclosed herein. In an example, an electronic device includes a wireless communication interface to transmit announcement signals for creating a wireless communication connection with the external device. The electronic device also includes a sensor to detect a characteristic of an environment external to the electronic device, and a control circuit including an announcement timing control module to dynamically control timing of the announcement signals based on the detected characteristic.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: March 6, 2018
    Assignee: Pacesetter, Inc.
    Inventors: Timothy Pflugh, Fujian Qu, Benjamin Coppola, Edward Karst, Lisa P. Weinberg
  • Publication number: 20170366921
    Abstract: Example electronic devices, including but not limited to implantable medical devices, and methods employing dynamic announcing for creation of wireless communication connections are disclosed herein. In an example, an electronic device includes a wireless communication interface to transmit announcement signals for creating a wireless communication connection with the external device. The electronic device also includes a sensor to detect a characteristic of an environment external to the electronic device, and a control circuit including an announcement timing control module to dynamically control timing of the announcement signals based on the detected characteristic.
    Type: Application
    Filed: August 31, 2017
    Publication date: December 21, 2017
    Inventors: Timothy Pflugh, Fujian Qu, Benjamin Coppola, Edward Karst, Lisa P. Weinberg, Xing Pei, Yongjian Wu
  • Publication number: 20170332942
    Abstract: Example electronic devices, including but not limited to implantable medical devices, and methods employing dynamic announcing for creation of wireless communication connections are disclosed herein. In an example, an electronic device includes a wireless communication interface to transmit announcement signals for creating a wireless communication connection with the external device. The electronic device also includes a sensor to detect a characteristic of an environment external to the electronic device, and a control circuit including an announcement timing control module to dynamically control timing of the announcement signals based on the detected characteristic.
    Type: Application
    Filed: June 15, 2016
    Publication date: November 23, 2017
    Inventors: Timothy Pflugh, Fujian Qu, Benjamin Coppola, Edward Karst, Lisa P. Weinberg
  • Publication number: 20170259066
    Abstract: The present disclosure provides systems and methods for disrupting neuronal oscillations. A neurostimulation system includes a stimulation lead comprising at least one contact, and an implantable pulse generator (IPG) communicatively coupled to the stimulation lead and configured to cause stimulation to be applied to a patient using no more than two contacts of the stimulation lead by causing a first burst of stimulation to be delivered, and causing a second burst of stimulation to be delivered within a neuronal refractory period that follows the first burst of stimulation.
    Type: Application
    Filed: March 8, 2016
    Publication date: September 14, 2017
    Inventors: Edward Karst, Alexander Kent, Lalit Venkatesan, Timothy A. Fayram
  • Publication number: 20170216597
    Abstract: The present disclosure provides a spinal cord stimulation (SCS) system. The system includes at least one SCS lead including a lead body, at least one distal electrode located at a distal end of the lead body, the at least one distal electrode configured to apply electrical stimulation to a stimulation target of a patient, and a pain reduction assembly coupled to the lead body and configured to reduce post-operation pain at an incision site associated with implantation of the at least one SCS lead. The system further includes a pulse generator coupled to the at least one SCS lead and configured to control electrical stimulation delivered to the patient via the at least one SCS lead.
    Type: Application
    Filed: February 11, 2016
    Publication date: August 3, 2017
    Inventors: Wenbo Hou, Alexander Kent, Edward Karst, Gene A. Bornzin, Riddhi Shah, Caroline Jordan, Yelena Nabutovsky