Patents by Inventor Edward Keystone

Edward Keystone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for determining efficacy of TNF-? inhibitors for treatment of rheumatoid arthritis
    Patent number: 9399061
    Abstract: The invention provides methods, uses and compositions for the treatment of rheumatoid arthritis. The invention describes methods and uses for treating rheumatoid arthritis wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment of rheumatoid arthritis in a subject.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: July 26, 2016
    Assignee: ABBVIE BIOTECHNOLOGY LTD
    Inventors: Hartmut Kupper, Jeffrey D. Kent, Mary A. Cifaldi, John L. Perez, Gerd R. Burmester, Philip Mease, Daniel J. Lovell, Edward Keystone, Arthur Kavanaugh
  • Methods of diagnosing and treating rheumatoid arthritis and osteoarthritis
    Patent number: 7776313
    Abstract: The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: August 17, 2010
    Assignees: University Health Network, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eleanor Fish, Carole Galligan, Kathy Siminovitch, Omar Perez, Edward Keystone, Vivian Bykerk
  • Uses and compositions for treatment of rheumatoid arthritis
    Publication number: 20080166348
    Abstract: The invention provides methods, uses and compositions for the treatment of rheumatoid arthritis. The invention describes methods and uses for treating rheumatoid arthritis wherein a TNF? inhibitor, such as a human TNF? antibody, or antigen-binding portion thereof. Also described are methods for determining the efficacy of a TNF? inhibitor for treatment of rheumatoid arthritis in a subject.
    Type: Application
    Filed: April 10, 2007
    Publication date: July 10, 2008
    Inventors: Hartmut Kupper, Jeffrey D. Kent, Mary A. Cifaldi, John L. Perez, Gerd R. Burmester, Philip Mease, Daniel J. Lovell, Edward Keystone, Arthur Kavanaugh
  • Methods of diagnosing and treating rheumatoid arthritis and osteoarthritis
    Publication number: 20070292881
    Abstract: The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using gene expression profiles, protein expression profiles, and/or protein phosphorylation profiles of different cell types, including the novel precursor, CD3+ cells, synovial tissue fibroblast-like synovial cells and fibrocytes. The invention also includes methods to identify substances to treat or prevent rheumatoid arthritis and/or osteoarthritis.
    Type: Application
    Filed: May 25, 2007
    Publication date: December 20, 2007
    Inventors: Eleanor Fish, Carole Galligan, Kathy Siminovitch, Omar Perez, Edward Keystone, Vivian Bykerk