Abstract: A cold compress for therapeutic cooling that has a permanently sealed flexible elastic bag comprised of a water and water vapor impermeable film. The bag contains free-flowing spheres, each having a shell and containing a material having a freezing point appropriate to a cold compress temperature. The sealed bag is free of any fluid that causes bridging between the spheres to prevent free-flowing of the spheres. When cooled, the cold compress remains flexible and elastic; and the spheres remain free-flowing such that the cold compress can conform to a simply curved or compound curved surface of the human body to thereby present a heat transfer contact surface area. The absorbed body heat provides latent heat of liquefaction to frozen material inside the spheres such that a temperature of the cold compress is substantially maintained for a longer time.