Abstract: The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Abstract: An ultrasonic therapy system delivers ultrasonic therapy energy to a therapy site in the body which is infused with microbubbles. A system without an image guidance capability has an array transducer which delivers therapy energy, a therapy transducer driver which causes the array transducer to deliver therapeutic energy, a control for controlling the intensity of the therapeutic energy, and a display of the sonotherapy signal strength of the energy and the concentration of microbubbles at the therapy site. A system with ultrasonic imaging capability will display an ultrasound image for therapeutic guidance and a measure of the microbubble concentration. The method of the present invention is performed as an adjunct to a standard drug therapy or other treatment regimen, following such treatment with an infusion of ultrasound and delivery of ultrasound therapy energy.

Abstract: Aspects of the subject disclosure may include, for example, detecting that an IMSI associated with a first SIM is provisioned onto a first mobile device and designating the IMSI into an available state. Further embodiments can include determining an expiry period for the available state. Additional embodiments can include purging the IMSI from a plurality of mobile network devices and designating the IMSI into a reclaimable state in response to an expiration of the expiry period. Other embodiments are disclosed.

Abstract: An ultrasound system and method are described for acquiring a sequence of ultrasound images of the carotid artery during the delivery of a contrast agent. Plaque in the images is identified and a time-intensity curve is calculated for pixels in the images. The intensity values before and after the arrival of contrast are compared to identify pixels or groups of pixels having perfusion. An anatomical image may be formed showing areas in an image of the plaque of the intensity and presence of perfusion, or the perfusion may be quantified by determining the percentage of pixels in the plaque image which exhibit perfusion. The extent and degree of perfusion is an indicator of the risk of plaque particulates in the blood stream which may lead to stroke-related symptoms.

Abstract: Aspects of the subject disclosure may include, for example, detecting that an IMSI associated with a first SIM is provisioned onto a first mobile device and designating the IMSI into an available state. Further embodiments can include determining an expiry period for the available state. Additional embodiments can include purging the IMSI from a plurality of mobile network devices and designating the IMSI into a reclaimable state in response to an expiration of the expiry period. Other embodiments are disclosed.

Abstract: An ultrasound system and method are described for acquiring a sequence of ultrasound images of the carotid artery during the delivery of a contrast agent. Plaque in the images is identified and a time-intensity curve is calculated for pixels in the images. The intensity values before and after the arrival of contrast are compared to identify pixels or groups of pixels having perfusion. An anatomical image may be formed showing areas in an image of the plaque of the intensity and presence of perfusion, or the perfusion may be quantified by determining the percentage of pixels in the plaque image which exhibit perfusion. The extent and degree of perfusion is an indicator of the risk of plaque particulates in the blood stream which may lead to stroke-related symptoms.

Abstract: Aspects of the subject disclosure may include, for example, detecting that an IMSI associated with a first SIM is provisioned onto a first mobile device and designating the IMSI into an available state. Further embodiments can include determining an expiry period for the available state. Additional embodiments can include purging the IMSI from a plurality of mobile network devices and designating the IMSI into a reclaimable state in response to an expiration of the expiry period. Other embodiments are disclosed.

Abstract: An ultrasound system and method are described for acquiring a sequence of ultrasound images of the carotid artery during the delivery of a contrast agent. Plaque in the images is identified and a time-intensity curve is calculated for pixels in the images. The intensity values before and after the arrival of contrast are compared to identify pixels or groups of pixels having perfusion. An anatomical image may be formed showing areas in an image of the plaque of the intensity and presence of perfusion, or the perfusion may be quantified by determining the percentage of pixels in the plaque image which exhibit perfusion. The extent and degree of perfusion is an indicator of the risk of plaque particulates in the blood stream which may lead to stroke-related symptoms.

Abstract: This disclosure considers a vehicle routing problem with pickup and delivery, time windows, and location resource constraints. Locations provide a number of cumulative resources that are utilized by vehicles either during service (e.g., forklifts) or for the entirety of their visit (e.g., parking bays). The problem is highly challenging from a computational standpoint as the resource constraints add temporal dependencies between vehicles and a scheduling substructure not featured in traditional vehicle routing problems. The main contribution of this disclosure is a branch-and-price-and-check model that incorporates a branch-and-price algorithm that solves the underlying vehicle routing problem, and a constraint programming subproblem that checks the feasibility of the location resource constraints, and then adds combinatorial nogood cuts to the master problem if the resource constraints are violated.

Abstract: An ultrasonic therapy system delivers ultrasonic therapy energy to a therapy site in the body which is infused with microbubbles. A system without an image guidance capability has an array transducer which delivers therapy energy, a therapy transducer driver which causes the array transducer to deliver therapeutic energy, a control for controlling the intensity of the therapeutic energy, and a display of the sonotherapy signal strength of the energy and the concentration of microbubbles at the therapy site. A system with ultrasonic imaging capability will display an ultrasound image for therapeutic guidance and a measure of the microbubble concentration. The method of the present invention is performed as an adjunct to a standard drug therapy or other treatment regimen, following such treatment with an infusion of ultrasound and delivery of ultrasound therapy energy.

Abstract: An ultrasound system and method are described for acquiring a sequence of ultrasound images of the carotid artery during the delivery of a contrast agent. Plaque in the images is identified and a time-intensity curve is calculated for pixels in the images. The intensity values before and after the arrival of contrast are compared to identify pixels or groups of pixels having perfusion. An anatomical image may be formed showing areas in an image of the plaque of the intensity and presence of perfusion, or the perfusion may be quantified by determining the percentage of pixels in the plaque image which exhibit perfusion. The extent and degree of perfusion is an indicator of the risk of plaque particulates in the blood stream which may lead to stroke-related symptoms.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for presenting error information. Logs are received from different locations, the logs associated with a plurality of builds at the different locations and associated with one or more systems. The logs are stored in a centralized location. Build information is generated for a given build, including identifying errors associated with the given build. Information for a current log associated with the given build is analyzed, including accessing information for previous logs associated with previous related builds related to the given build. Based on the analyzing, error diagnostic information that is to be presented is determined, including an analysis of errors that occurred in the given build and previous related builds. Instructions are provided, the instructions operable to present the error diagnostic information to a user, including providing log information, for presentation in a user interface.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for presenting error information. An indication is received of a selected error for a product installation. Installations are identified having a matching stream, build number and error. Other builds in a same stream having the same error are identified. Information is provided for displaying a graph having a horizontal line graph including first nodes representing builds in the same stream having the same error. Other occurrences of the error in builds of other streams are identified. Information for updating the graph is provided with parallel lines for each of the other streams, each parallel line including second nodes representing builds. An oldest one of the first nodes and second nodes is identified. Information is provided for presenting a list of potential changes occurring before the date associated with the oldest node and that are candidates for causing the error.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for presenting error information. Logs are received from different locations, the logs associated with a plurality of builds at the different locations and associated with one or more systems. The logs are stored in a centralized location. Build information is generated for a given build, including identifying errors associated with the given build. Information for a current log associated with the given build is analyzed, including accessing information for previous logs associated with previous related builds related to the given build. Based on the analyzing, error diagnostic information that is to be presented is determined, including an analysis of errors that occurred in the given build and previous related builds. Instructions are provided, the instructions operable to present the error diagnostic information to a user, including providing log information, for presentation in a user interface.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for presenting error information. An indication is received of a selected error for a product installation. Installations are identified having a matching stream, build number and error. Other builds in a same stream having the same error are identified. Information is provided for displaying a graph having a horizontal line graph including first nodes representing builds in the same stream having the same error. Other occurrences of the error in builds of other streams are identified. Information for updating the graph is provided with parallel lines for each of the other streams, each parallel line including second nodes representing builds. An oldest one of the first nodes and second nodes is identified. Information is provided for presenting a list of potential changes occurring before the date associated with the oldest node and that are candidates for causing the error.

Abstract: A method for assessing a liver includes acquiring image information including contrast-enhanced ultrasound images of the liver. A location of the main hepatic artery (MHA) and a location of the main portal vein (MPV) of the liver are identified in at least one of the contrast-enhanced ultrasound images of the liver. Time-intensity information corresponding to perfusion of a contrast agent in the MHA and the MPV is obtained. A biomarker index value (BW) which is a function of the time-intensity information corresponding to the perfusion of contrast agent in the MHA and the time-intensity information corresponding to the perfusion of contrast agent in the MPV is determined.

Abstract: A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a control unit for directing operations of the workstation and the operation unit for performing the production of the tissue column array. The operation unit comprises an array of vertical tubes in a platform, an arbor which engages and presses down the designated tube in the array, the embedded tissue block which is mounted directly below the designated tube, assemblies of motors responsive to the control unit for driving the platform and the tissue block, a light source block for generating an alignment signal, and a light detector block which measures the signal from the light source to determine the degree of alignment between the arbor, punch tubes, and the specimen block.

Abstract: A workstation that provides an efficient method to collect biological tissues in a column tissue array format from blocks of embedded, frozen tissues, or fresh tissues. The workstation has a control unit for directing operations of the workstation and the operation unit for performing the production of the tissue column array. The operation unit comprises an array of vertical tubes in a platform, an arbor which engages and presses down the designated tube in the array, the embedded tissue block which is mounted directly below the designated tube, assemblies of motors responsive to the control unit for driving the platform and the tissue block, a light source block for generating an alignment signal, and a light detector block which measures the signal from the light source to determine the degree of alignment between the arbor, punch tubes, and the specimen block.

Abstract: An air intake noise suppression device comprises a housing defining a passage having a relatively small height, preferably no greater than one-half inch, and a length defined by the expression ##EQU1## where H is the height of the passage and f is the desired noise frequency to be suppressed. The width of the passage is selected to be large enough to provide an adequate supply of intake air to the engine. With the passage essentially defining a relatively narrow slot, it is filled with acoustic boundary layers that accentuate noise significantly over a relatively wide frequency range.

Abstract: A photosensitive diazo resin-containing photosensitive resin composition for lithographic printing comprising a sensitizing dye having an anion group in a molecule as a counter ion of a diazonium group.