Abstract: Compositions, methods, and kits are provided for determining whether a subject is at risk of developing insulin resistance. In particular, phosphorylated Akt, reactive oxygen species (ROS), SIRT1, eNOS, CDH13, IRS1 and NO production have been identified as biomarkers associated with insulin resistance and type 2 diabetes. The diagnostic methods comprise measuring the level of at least one biomarker in induced pluripotent stem cells derived from somatic cells of the subject, which have been differentiated into endothelial cells (IPSC-ECs).

Abstract: A manufacturing method including providing a mold including at least two mold parts having first and second molding surfaces which are complementarily profiled to give shape to headwear; shaping a first substrate in the mold resulting in the first substrate having a non-planar profile which matches at least a portion of the profile of the molding surfaces; shaping a second substrate in the mold resulting in the second substrate having a non-planar profile which matches the profile of the molding surfaces; overlaying the first substrate on the second substrate and matching their non-planar profile to form a combined substrate; placing a third substrate in the mold with the combined substrate, sandwiching the first substrate; and shaping the third substrate with the combined substrate in the mold resulting in the third substrate having a non-planar profile which matches the profile of the molding surfaces, thereby forming a seamless structure for the headwear.

Abstract: Disclosed is a method for determining the turnover rate of biomolecules in a subject, which include administering to the subject, 2H2O in an amount sufficient to label biomolecules in the subject with 2H. Samples are collected from the subject at one or more time points and isotopomers are detected for the labeled biomolecules in the samples. The fractional abundance is determined for the isotopomers of the biomolecules in the samples and the biomolecule turnover rates of the one or more labeled biomolecules is determined based on the fractional abundance of the isotopomers. A computer-implemented method is also disclosed for determining the turnover rate of one or more biomolecules in subject. In certain other embodiments, a system for determining protein turnover rates in a subject is also provided. Also provided in certain embodiments is a computer program product for determining protein turnover rates in a subject.

Abstract: An electronic device utilizes gesture input and an item selection method to improve selection speed and accuracy. An item of an array of items may represent, for example and without limitation, a typing character, an icon that triggers a corresponding routine, or a subset of items. A processor of the electronic device passes gesture navigation input to an item selection routine. The item selection routine converts gesture navigation input to a standard, magnitude independent pointer. The item selection routine then uses the standard point data to select a desired item from the array of items. Since the selection is not determined by the exact direction and magnitude of the gesture input, selection accuracy can be enhanced. By employing the item selection method, item selection traverse paths can be cycled within a confined sensing region; it can improve the selection speed and make it suitable for small-sized devices.

Abstract: A manufacturing method including providing a mould including at least two mould parts having first and second moulding surfaces which are complementarily profiled to give shape to headwear; shaping a first substrate in the mould resulting in the first substrate having a non-planar profile which matches at least a portion of the profile of the moulding surfaces;shaping a second substrate in the mould resulting in the second substrate having a non-planar profile which matches the profile of the moulding surfaces; overlaying the first substrate on the second substrate and matching their non-planar profile to form a combined substrate; placing a third substrate in the mould with the combined substrate, sandwiching the first substrate; and shaping the third substrate with the combined substrate in the mould resulting in the third substrate having a non-planar profile which matches the profile of the moulding surfaces, thereby forming a seamless structure for the headwear.

Abstract: An electronic device utilizes gesture input method of item selection to perform various input actions. An item of a plurality of items may represent, for example and without limitation, a character, a symbol, or an icon. One or more input sensors of the electronic device capture gesture navigation input and an item selection routine converts the input into a standard, magnitude independent pointer, and then determines the corresponding item. Since the selection is not determined by the exact direction and magnitude of the gesture input, selection accuracy can be greatly enhanced. By employing the item selection routine and standard pointers, item selection traverse paths can be cycled within a confined sensing region, thus selection speed can be improved and device size can be reduced. By memorizing the traverse paths, user can select a desired item without looking at the display, thereby being accessible to visually impaired users.

Abstract: A fluid cooling pad system 10 utilizes compressed air as a cooling source. Compressed air 205 can provide a cooling effect for the fluid cooling pad system 10. By using a compressed air cartridge 300 to store the compressed air 205, the fluid cooling pad system is easy to maintain and the fluid cooling pad system size can be reduced. The cooling effect can also be extended by replacing an empty compressed air cartridge 300 with a filled compressed air cartridge 300. By further including a manual air pump 500 or powered air pump 600, compressed air cartridge 300 can be refilled. The fluid cooling pad system 10 is also expandable. By connecting connection tubes 107 to multiple fluid cooling pads 100, user can attach the fluid cooling pads 100 to multiple areas simultaneously, for example and without limitation, on wearable garments such as caps, helmets, and/or applied directly to the user's body.

Abstract: An electronic device utilizes gesture input method of item selection to perform various input actions. An item of a plurality of items may represent, for example and without limitation, a character, a symbol, or an icon. One or more input sensors of the electronic device capture gesture navigation input and an item selection routine converts the input into a standard, magnitude independent pointer, and then determines the corresponding item. Since the selection is not determined by the exact direction and magnitude of the gesture input, selection accuracy can be greatly enhanced. By employing the item selection routine and standard pointers, item selection traverse paths can be cycled within a confined sensing region, thus selection speed can be improved and device size can be reduced. By memorizing the traverse paths, user can select a desired item without looking at the display, thereby being accessible to visually impaired users.

Abstract: Disclosed is a method for determining the turnover rate of biomolecules in a subject, which include administering to the subject, 2H20 in an amount sufficient to label biomolecules in the subject with 2H. Samples are collected from the subject at one or more time points and isotopomers are detected for the labeled biomolecules in the samples. The fractional abundance is determined for the isotopomers of the biomolecules in the samples and the biomolecule turnover rates of the one or more labeled biomolecules is determined based on the fractional abundance of the isotopomers. A computer-implemented method is also disclosed for determining the turnover rate of one or more biomolecules in subject. In certain other embodiments, a system for determining protein turnover rates in a subject is also provided. Also provided in certain embodiments is a computer program product for determining protein turnover rates in a subject.

Abstract: A method and system is disclosed for enabling the accurate determination of price points (APRs), credit limits, and other discretionary levels for each cardholder that maximize Net Present Value (NPV) for the portfolio, given constraints on quantities such as risk of default. In accordance with one embodiment, the present invention uses a Markov Decision Process (MDP) methodology to generate a simplified transition matrix representative of the potential state transitions for account holders. This model applies account level historical information on purchases, payments, profitability and delinquency risk to make these decisions. In addition, a data structure is disclosed constructed to implement a transition matrix computationally in different sizes.

Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.

Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.

Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.

Abstract: A method and system is disclosed for enabling the accurate determination of price points (APRs), credit limits, and other discretionary levels for each cardholder that maximize Net Present Value (NPV) for the portfolio, given constraints on quantities such as risk of default. In accordance with one embodiment, the present invention uses a Markov Decision Process (MDP) methodology to generate a simplified transition matrix representative of the potential state transitions for account holders. This model applies account level historical information on purchases, payments, profitability and delinquency risk to make these decisions. In addition, a data structure is disclosed constructed to implement a transition matrix computationally in different sizes.

Abstract: The present invention provides for a system and method for identifying optimal marketing offers in a mass marketing campaign. An optimal offer for a particular prospect at a particular time in the multi-wave campaign is determined. In accordance with one embodiment of the present invention, offer information is initially collected for each of the various offers tagged for potential inclusion into a. Each offer is analyzed to determine its eligibility for inclusion in a marketing campaign to a particular household or individual prospect within a household. A systematic evaluation of eligibility applies a plurality of predetermined criteria to each offer on a household level, a prospect level and an offer level. In this manner, offers failing such criteria may be easily removed from inclusion in the campaign. A net present value (NPV) and a net response rate may be calculated for each eligible offer to identify one or more optimal marketing offers.

Abstract: A graphical user interface includes a scroll area displaying search results and a permanently displayed anchored area.

Abstract: A graphical user interface includes configurable parameters to format search results. The configurable parameters include configurable parameters to specify column configuration and textual summary length.

Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations affect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.

Abstract: A method for offer management may comprise: providing a plurality of offers for targeting at a plurality of accounts based on a plurality of business rules; prioritizing the plurality of offers; grouping the accounts based on their qualification for each offer in accordance with the business rules; optimizing the business rules based on the prioritization of the offers and the grouping of the accounts, such that each offer is associated with at least a predetermined number of accounts; imposing a volume limit or weight limit for offers assigned to each account; incorporating the offers into communications associated with the plurality of accounts based on the optimized business rules and the volume limit or weight limit; and managing production of the communications based on at least one simulation, wherein the at least one simulation is performed based on data associated with the offers, business rules and the accounts.

Abstract: The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event.