Patents by Inventor Edward Lavallie
Edward Lavallie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070178574Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.Type: ApplicationFiled: August 24, 2006Publication date: August 2, 2007Applicant: WYETHInventors: Lydia Mosyak, Thomas Rush, Xiaotian Zhong, Thomas McDonagh, Katy Georgiadis, Phaik-Eng Sum, Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Ravindra Kumar, Tracy Hebert, Stephane Olland, Stewart Mackie
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Publication number: 20070161046Abstract: Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.Type: ApplicationFiled: December 15, 2006Publication date: July 12, 2007Applicant: WyethInventors: Katy Georgiadis, Tara Crawford, Kathleen Tomkinson, Lisa Collins-Racie, Christopher Corcoran, Bethany Freeman, Edward LaVallie
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Publication number: 20070128616Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.Type: ApplicationFiled: May 22, 2006Publication date: June 7, 2007Applicant: WyethInventors: Christopher Corcoran, Michael Agostino, Edward LaVallie, Carl Flannery, Weilan Zeng, Lisa Collins-Racie, Bethany Freeman
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Publication number: 20070105207Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.Type: ApplicationFiled: August 24, 2006Publication date: May 10, 2007Applicant: WYETHInventors: Lydia Mosyak, Thomas Rush, Stephane Olland, Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Stewart Mackie
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Publication number: 20060269957Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.Type: ApplicationFiled: July 12, 2006Publication date: November 30, 2006Applicant: Ono Pharmaceutical Co. Ltd.Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael Bowman, Vikki Spaulding, McKeough Carlin-Duckett, Kerry Kelleher
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Publication number: 20060257989Abstract: Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.Type: ApplicationFiled: July 18, 2006Publication date: November 16, 2006Applicant: WyethInventors: Katy Georgiadis, Tara Crawford, Kathleen Tomkinson, Lisa Collins-Racie, Christopher Corcoran, Bethany Freeman, Edward LaVallie
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Publication number: 20060228354Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.Type: ApplicationFiled: June 12, 2006Publication date: October 12, 2006Applicant: WyethInventors: Christopher Corcoran, Carl Flannery, Weilan Zeng, Lisa Racie, Thomas McDonagh, Bethany Freeman, Katy Georgiadis, Edward LaVallie
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Publication number: 20060177904Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.Type: ApplicationFiled: April 3, 2006Publication date: August 10, 2006Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, David Merberg, Michael Agostino, Robert Steininger, Vikki Spaulding, Gordon Wong, Hilary Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
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Publication number: 20060111562Abstract: Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.Type: ApplicationFiled: December 16, 2005Publication date: May 25, 2006Applicant: Genetics Institute, LLCInventors: Edward LaVallie, Lisa Racie, Gary Hattersley
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Publication number: 20060063227Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.Type: ApplicationFiled: December 14, 2004Publication date: March 23, 2006Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael Bowman, Vikki Spaulding, Michael Agostino
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Publication number: 20050277175Abstract: The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.Type: ApplicationFiled: April 18, 2005Publication date: December 15, 2005Applicant: WYETHInventors: Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Natalie Twine, Michael Agostino
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Publication number: 20050260733Abstract: The present invention features methods of using ADAMTS-8 proteins or their functional derivatives to cleave aggrecan or other proteoglycan molecules. The present invention also features methods for identifying ADAMTS-8 modulators that are capable of inhibiting or enhancing ADAMTS-8 proteolytic activities. In addition, the present invention features pharmaceutical compositions comprising ADAMTS-8 proteins or their derivatives or modulators. These pharmaceutical compositions can be used to treat diseases that are characterized by deficiencies or abnormalities in proteoglycan cleavage or metabolism.Type: ApplicationFiled: April 15, 2005Publication date: November 24, 2005Applicant: WYETHInventors: Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Michael Agostino, Bethany Freeman, Maya Arai, Carl Flannery, Macy Jin
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Publication number: 20050250180Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.Type: ApplicationFiled: October 22, 2003Publication date: November 10, 2005Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
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Publication number: 20050003491Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.Type: ApplicationFiled: August 9, 2004Publication date: January 6, 2005Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael Agostino, Robert Steininger, Vikki Spaulding, Gordon Wong, Hilary Clark, Kim Fechtel
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Patent number: 6165748Abstract: Purified Frazzled proteins, including WG67-16, WG67-19 and WA628, and processes for producing them are disclosed. DNA molecules encoding the Frazzled proteins, including WG67-16, WG67-19 and WA628, are also disclosed. The proteins may be used in modulating the binding of Wnt genes to their receptor. They are useful in the modulation of cellular formation, growth, differentiation, proliferation and/or maintenance of a variety of adult and embryonic tissues and organs.Type: GrantFiled: July 11, 1997Date of Patent: December 26, 2000Assignees: Genetics Institute, Inc., Whitehead Institute for Biomedical ResearchInventors: Lisa Racie, Edward Lavallie, Janet Paulsen, Hazel Sive, Benjamin Sun