Patents by Inventor Edward M. Acton
Edward M. Acton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4826964Abstract: Compounds of the formula ##STR1## wherein R is --COCH.sub.3, --CHOHCH.sub.3, --COCH.sub.2 OH, or --CHOHCH.sub.2 OH; hydrogen; hydroxyl; a 1 to 3 carbon alkyl; a 1 to 3 carbon .omega.-hydroxyalkyl; a 2 to 7 carbon organic acid ester or diester of --COCH.sub.2 OH, --CHOHCH.sub.2 OH, or --CHOHCH.sub.3 ; or the groups --COCH.sub.2 OH, --CHOHCH.sub.2 OH, or --CHOHCH.sub.3 having a 1 to 6 carbon alkyl or aryl ether replacement of one or more hydroxyls; or 13-ketimine derivatives of --COCH.sub.3 or --COCH.sub.2 OH;Y is methoxy, hydroxy, or hydrogen; and X is O or NH, but when Y is hydroxy or hydrogen, X must be O;and wherein R' is a 1 to 3 carbon alkyl; andor wherein Z is O, S, CH.sub.2 or CHOR' wherein R' is 1 to 3 carbon alkyl,and the pharmaceutically acceptable acid additive salts thereof; are useful for retarding tumor proliferation.Type: GrantFiled: April 25, 1986Date of Patent: May 2, 1989Assignee: SRI InternationalInventors: Edward M. Acton, George L. Tong
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Patent number: 4705850Abstract: Disclosed herein is a new procedure for preparing the C.1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are particularly useful for the preparation of intermediates in the synthesis of adriamycin C-glycosidic analogs which are useful anti-tumor agents. These methods provide the first enabling disclosure of methods to prepare these desired adriamycin and anthrocyclinone C-glycosidic analogs.Type: GrantFiled: November 23, 1984Date of Patent: November 10, 1987Assignee: SRI InternationalInventors: Edward M. Acton, Kenneth J. Ryan, Michael Tracy
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Patent number: 4591637Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein R is: --CO--CH.sub.3, --CHOH--CH.sub.3, --CO--CH.sub.2 OH, --CHOH--CH.sub.2 OH, hydrogen, hydroxy, 1 to 3 carbon alkyl, 1 to 3 carbon terminal hydroxyalkyl; or,a 2 to 7 carbon ester or diester of said --CO--CH.sub.2 OH, --CHOH--CH.sub.2 OH, --CHOH--CH.sub.3 or of said 1 to 3 carbon terminal hydroxyalkyl; orsaid --CO--CH.sub.2 OH, --CHOH--CH.sub.2 OH, or --CHOH--CH.sub.3 or said 1 to 3 C-terminal hydroxyalkyl having 1 to 6 carbon alkyl or aryl ether replacements of one or more of the hydroxyls; orthe 13-ketimine derivatives of --CO--CH.sub.3 and --CO--CH.sub.2 OH;Y is hydrogen, hydroxy, or methoxy,X is O or NH, but when Y is hydrogen or hydroxy, X must be O;at least one of R.sup.1 and R.sup.Type: GrantFiled: January 17, 1985Date of Patent: May 27, 1986Assignee: SRI InternationalInventors: Edward M. Acton, George L. Tong
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Patent number: 4585859Abstract: A group of new daunorubicin and doxorubicin derivatives is disclosed. Included in this group are 3'-deamino-3'(3"-cyano-4"-morpholinyl doxorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-13-dihydoxorubicin; (3'-deamino-3'-(3"-cyano-4"-morpholinyl) daunorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-3-dihydrodaunorubicin; and 3'-deamino-3'-(4"-morpholinyl-5-iminodoxorubicin and derivatives thereof which have excellent activity as antitumor agents.Type: GrantFiled: April 9, 1984Date of Patent: April 29, 1986Assignee: SRI InternationalInventors: Carol W. Mosher, George L. Tong, Edward M. Acton
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Patent number: 4464529Abstract: A group of new daunorubicin and doxorubicin derivatives is disclosed. These materials have the formula ##STR1## wherein R is CO--CH.sub.3 or CHOH--CH.sub.3 in the case of daunorubicin derivatives or CO--CH.sub.2 OH or CHOH--CH.sub.2 OH in the case of doxorubicin derivatives; X is O or NH; and A is either a cyano group (CN) or a hydrogen, subject to the limitation that when X is O, A must be a cyano group. When A is hydrogen, these compounds can exist as acid addition salts, as well. Derivatives of these compounds are disclosed as well.Type: GrantFiled: May 24, 1983Date of Patent: August 7, 1984Assignee: SRI InternationalInventors: Carol W. Mosher, George L. Tong, Edward M. Acton
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Patent number: 4353894Abstract: 5-Iminodoxorubicin and its pharmaceutically acceptable acid addition salts having good antitumor activity.Type: GrantFiled: November 2, 1981Date of Patent: October 12, 1982Assignee: SRI InternationalInventors: Edward M. Acton, George L. Tong
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Patent number: 4314054Abstract: Described are 3'-deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH.sub.3 or --CHOHCH.sub.3 in the case of daunorubicin derivatives, or is COCH.sub.2 OH or --CHOH--CH.sub.2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid salts. The compounds have utility as antitumor agents.Type: GrantFiled: March 23, 1981Date of Patent: February 2, 1982Assignee: SRI InternationalInventors: Edward M. Acton, Carol W. Mosher
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Patent number: 4301277Abstract: Described are 3'-deamino-3'-(4-morpholinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH.sub.3 or --CHOHCH.sub.3 in the case of daunorubicin derivatives, or is --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid addition salts. The compounds have utility as antitumor agents.Type: GrantFiled: October 20, 1980Date of Patent: November 17, 1981Assignee: SRI InternationalInventors: Edward M. Acton, Carol W. Mosher
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Patent number: 4086416Abstract: Septacidin analogs, useful as antitumor agents, having the structure ##STR1## where R is a branched or straight chain alkanoyl group of from 12 to 16 carbon atoms. A preferred compound is 6-[4,6-dideoxy-4-(isopalmitoylglycyl)-amino-.beta.-L-glucopyranosylamino]- 9H-purine.Type: GrantFiled: May 17, 1977Date of Patent: April 25, 1978Assignee: Stanford Research InstituteInventors: Edward M. Acton, Kenneth J. Ryan
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Patent number: 3952114Abstract: New compounds 4-methyl-1,4-cyclohexadiene-1-carboxaldehyde syn-oxime, 4-methoxymethyl-1,4-cyclohexadiene-1-carboxaldehyde syn-oxime, and 4-(1-methoxyethyl)-1,4-cyclohexadiene-1-carboxaldehyde syn-oxime, as well as the compound 1,4-cyclohexadiene-1-carboxaldehyde syn-oxime, are found to have a high degree of sweetness which is accompanied by very little off-taste. The compounds have good stability even in acid solution. They give no evidence of toxicity and can be employed in foods and beverages as synthetic sweetening ingredients.Type: GrantFiled: August 25, 1975Date of Patent: April 20, 1976Assignee: Stanford Research InstituteInventors: Edward M. Acton, Michael W. Lerom, Herbert Stone
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Patent number: 3940383Abstract: New 3-methyl-3-nitrosoureido derivatives of the following amino sugars were prepared as analogs of streptozotocin with the anomeric carbon protected, by nitrosating the methylureas in water with N.sub.2 O.sub.3 : 3-amino-3-deoxy-1,2-O-isopropylidene-.alpha.-D-ribofuranose; methyl 3-amino-3-deoxy-.beta.-D-xylopyranoside; methyl 3-amino-3-deoxy-.alpha.-D-altropyranoside; methyl 3-amino-3-deoxy-.alpha.-D-glucopyranoside; and methyl 3-amino-2,3,6-trideoxy-.alpha.-L-lyxohexopyranoside. Tests against murine leukemia L1210 show that the anticancer activity of streptozotocin not only was retained but was enhanced in most of these derivatives.Type: GrantFiled: December 12, 1974Date of Patent: February 24, 1976Assignee: Stanford Research InstituteInventors: Allan N. Fujiwara, Edward M. Acton, David W. Henry