Abstract: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating io hematopoeitic progenitor cells and related products.

Abstract: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products.

Abstract: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products.

Abstract: Methods of altering transmembrane calcium transport by altering expression of a calcium-transport protein are described.

Abstract: The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater, The method includes: adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to modulate expression and/or sensitivity of at least one PVCR, the PVCR modulator being one which alters olfactory sensing of the fish to the odorant; adding feed for fish consumption to the freshwater, the feed containing the odorant and an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the fish upon consumption of the feed, whereby the fish are imprinted with the odorant; transferring the imprinted fish to seawater; and providing a source of said odorant in the seawater to which the imprinted fish are transferred, thereby causing the imprinted fish to react to

Abstract: Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

Abstract: The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater, The method includes: adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to modulate expression and/or sensitivity of at least one PVCR, the PVCR modulator being one which alters olfactory sensing of the fish to the odorant; adding feed for fish consumption to the freshwater, the feed containing the odorant and an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the fish upon consumption of the feed, whereby the fish are imprinted with the odorant; transferring the imprinted fish to seawater; and providing a source of said odorant in the seawater to which the imprinted fish are transferred, thereby causing the imprinted fish to react to

Abstract: Nucleic-acid and amino-acid sequences correspond to a calcium-transport protein regulating the movement of calcium across cell membranes.

Abstract: The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater.

Abstract: Methods of altering transmembrane calcium transport by altering expression of a calcium-transport protein are described.

Abstract: Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

Abstract: The present invention relates to methods of imprinting fish to be sensitized to an odorant so that modulation of the PVCR in the olfactory apparatus occurs, and then exposing the fish with the same odorant after transfer to seawater or freshwater. The present invention also includes methods of homing or attracting fish, as well as methods for repelling fish by modulating the expression and/or sensitivity of the PVCR in the olfactory apparatus of the fish.

Abstract: Nucleic-acid and amino-acid sequences correspond to a calcium-transport protein regulating the movement of calcium across cell membranes.

Abstract: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating hematopoeitic progenitor cells and related products.

Abstract: Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described.

Abstract: The present invention is directed to methods for treating cancer patients by administering ligands that bind with specificity to the calcium-sensing receptor. In addition, the invention is directed to methods for detecting transformed cells by determining the number of calcium-sensing receptors present.

Abstract: The present invention is directed to an avian calcium-sensing receptor and to DNA sequences which encode the receptor. In addition, the invention is directed to methods and compositions which serve to modulate the serum concentration of calcium in humans and animals.

Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.