Patents by Inventor Edward M. Fielden

Edward M. Fielden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing chiral [[(2-bromoethyl)-amino]methyl]-nitro-1H-imidazol-1-ethanol and related compounds
    Patent number: 5543527
    Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: August 6, 1996
    Assignees: British Technoloyg Group Limited, Warner-Lambert Company
    Inventors: Vladimir G. Beylin, Anthony D. Sercel, Howard D. H. Showalter, Gerald E. Adams, Edward M. Fielden, Matthew A. Naylor, Ian J. Stratford
  • Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment
    Patent number: 5521203
    Abstract: A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: May 28, 1996
    Assignee: British Technology Group Limited
    Inventors: Gerald E. Adams, Edward M. Fielden, Terence C. Jenkins, Ian J. Stratford
  • Process for preparing chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds
    Patent number: 5481000
    Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: January 2, 1996
    Assignee: Warner-Lambert Company
    Inventors: Vladimir G. Beylin, Anthony D. Sercel, Howard D. H. Showalter, Gerald E. Adams, Edward M. Fielden, Matthew A. Naylor, Ian J. Stratford
  • Process for preparing chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds
    Patent number: 5342959
    Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.
    Type: Grant
    Filed: August 5, 1993
    Date of Patent: August 30, 1994
    Assignees: Warner-Lambert Company, British Tech. Group
    Inventors: Vladimir Genukh Beylin, Anthony D. Sercel, Howard D. H. Showalter, Gerald E. Adams, Edward M. Fielden, Matthew A. Naylor, Ian J. Stratford
  • Nitro-substituted aromatic or hetero-aromatic compounds for use in cancer treatment
    Patent number: 5098921
    Abstract: A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: March 24, 1992
    Assignee: National Research Development Corporation
    Inventors: Gerald E. Adams, Edward M. Fielden, Terence C. Jenkins, Ian J. Stratford