Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: An automatic speech sensitivity adjustment feature is provided. The described sensitivity feature can enable an automatic system adjustment of a sensitivity level based on the number and type of determined speech errors. The sensitivity level determines how sensitive the sensitivity feature will be when indicating speech errors. The sensitivity feature can receive audio input comprising one or more spoken words and determine speech errors for the audio input using at least a sensitivity level. The sensitivity feature can determine whether an amount and type of the speech errors requires an adjustment to the sensitivity level. The sensitivity feature can adjust the sensitivity level to a second sensitivity level based on the amount and type of the speech errors, where the second sensitivity level is a different level than the sensitivity level. The sensitivity feature can re-determine the speech errors for the audio input using at least the second sensitivity level.

Abstract: A guided projectile that includes a warhead case, a cartridge case coupled to the warhead case, and a tail kit assembly positioned within the cartridge case. The tail kit assembly includes a hollow casing including a plurality of fin slots defined therein, a control fin selectively extendable from within the hollow casing through each fin slot of the plurality of fin slots, and a fin slot cover positioned within each fin slot with a minimum clearance fit such that the control fin is retained within the hollow casing. The fin slot cover is releasable from within each fin slot such that the control fin is deployable therethrough.

Abstract: A guided projectile that includes a warhead case, a cartridge case coupled to the warhead case, and a tail kit assembly positioned within the cartridge case. The tail kit assembly includes a hollow casing including a plurality of fin slots defined therein, a control fin selectively extendable from within the hollow casing through each fin slot of the plurality of fin slots, and a fin slot cover positioned within each fin slot with a minimum clearance fit such that the control fin is retained within the hollow casing. The fin slot cover is releasable from within each fin slot such that the control fin is deployable therethrough.