Abstract: A method, apparatus, and article of manufacture for dynamic change management in an extended remote copy system. A primary data mover monitors changes made to a primary data volume resulting from write I/O operations, wherein the changes are reflected in a data structure maintained by the primary data mover. The primary data mover performs a multi-level analysis on the data structure to discard a portion of the changes therein, so that the changes that have been applied to a secondary data volume are discarded from the data structure and the changes that have not been applied to the secondary data volume are maintained in the data structure.

Abstract: Disclosed is a system for isolating errors in a remote copy system. A first controller writes data to a volume in a first direct access storage device (DASD) and maintains a copy of the data in a cache. The first controller transfers the data in the cache to a host system via a first communication line. The host system then transfers the data transferred from the first controller to a second controller via a second communication line. The second controller writes the data transferred from the host system to a volume in a second DASD. A volume pair is comprised of a volume in the first DASD and a volume in the second DASD, wherein for each volume pair, the second DASD volume backs-up data stored in the first DASD volume. If an error related to a volume pair is detected, then the operation of transferring the data in the cache for the volume pair related to the error to the second controller via the host system is suspended. Information on the detected error is written to a first data set.

Abstract: The invention provides methods of performing a synthetic process in a liquid distribution system having reaction cells, by pumping at least one reagent into a reaction cell.

Abstract: A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate.

Abstract: A method of making a dielectric substrate array for conducting a plurality of reactions in parallel in a number of wells, the method comprising: forming a first passage and a second passage each extending through a dielectric substrate, the substrate having a first surface and an opposing second surface; forming a plurality of channels on said first or second surface, including a first channel, a second channel, a third channel and a fourth channel on the substrate, wherein the first channel is on the first surface and intersects with the first passage, wherein the second channel is on the second surface and intersects with both of the first passage and the second passage, wherein the third channel is on the first surface and intersects with the second passage, wherein the fourth channel is on the first surface and is located between the outlets of the first and second passage at the first surface, and wherein (a) the connected first channel, first passage, second channel, second passage and third channel def

Abstract: A hot-melt adhesive for use as a shoe last adhesive, particularly one in a form for use in a direct through feed adhesive dispensing system, made from a melt-blend of a copolymer of ethylene and carboxylic acid, a synthetic wax such as a Fischer-Tropsch wax, and an ethylene/unsaturated carboxylic acid wax having a melt index of at least about 5000 dg/min.

Abstract: The invention provides electrode-based pumps and methods of operating such pumps. In one embodiment, the invention provides an electrode-based pump situated in a fluid channel comprising a first electrode and a second electrode, wherein the first and second electrodes have a diameter from about 25 microns to about 100 microns and are spaced from about 100 microns to about 2,500 microns apart. In another embodiment, the invention provides an electrode-based pump comprising a first electrode, second electrode and third electrode.

Abstract: The present invention provides a method of performing an immunological assay separately and in parallel for each of at least a first sample containing or prospectively containing a first binding moiety, which can be an antigen or an antibody, and a second sample containing or prospectively containing the first binding moiety, the method comprising: placing the first sample and the second sample into an array comprising a solid substrate, a plurality of wells and channels, wherein at least one channel is a crossover channel formed in the upper surface of the substrate and is situated above another channel formed in the lower surface of the substrate, thereby forming crossovers comprising crossing but non-intersecting channels; moving said first sample into a first well containing a second binding moiety, which can be an antigen or an antibody, that binds to the first binding moiety, wherein the second binding moiety is bound to the walls of the first well; moving said second sample into a second well containin

Abstract: The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The distribution system can comprise an alpha reservoir and a beta reservoir, a first set of parallel and adjacent first and second feeder channels and a second set of parallel and adjacent third and fourth feeder channels which are offset from the first and second feeder channels, wherein (a) the first and third feeder channels are connected to the alpha reservoir via a first connector channel that is situated above or below the second and fourth feeder channels and are independent of the beta reservoir and (b) the second and fourth feeder channels are connected to the beta reservoir via a second connector channel that is situated above or below the first and third feeder channels and are independent of the alpha reservoir. The distribution system is preferably a microscale distribution system.

Abstract: Data is stored in one or more data storage devices, the number of active data storage devices being adaptively adjusted to maximize parallelism while minimizing device overhead. Multiple datasets are first received, these being designated for storage in multiple data storage devices. Next, a first one of the received datasets is stored in a first one of the data storage devices. Concurrently with storage of the first dataset, the following steps are performed: (1) selecting a second received dataset from those remaining to be stored, (2) selecting an available data storage device by employing a predetermined criteria, and (3) beginning storage of the second dataset in the selected data storage device. The predetermined criteria for selecting an available data storage device may involve, for example, selecting an available device based on a "first fit" or a "best fit" scheme. Concurrently with storage of the second dataset, storage of a third dataset starts.

Abstract: A system for processing a plurality of tests or syntheses in parallel comprising a sample channel for moving samples into a microlaboratory array of a plurality of wells connected by one or more channels for the testing or synthesis of samples, a station for housing the array and an optical system comprising at least one light source and at least one light detector for measuring the samples in the array, and a means of electrically connecting said array to an apparatus capable of monitoring and controlling the flow of fluids into the array.Samples are loaded from a common loading channel into the array, processed in the wells and measurements taken by the optical system. The array can process many samples, or synthesize many compounds in parallel, reducing the time required for such processes.

Abstract: A remote data shadowing system provides storage based, real time disaster recovery capability. Record updates at a primary site cause write I/O operations in a storage subsystem therein. The write I/O operations are time stamped and the time, sequence, and physical locations of the record updates are collected in a primary data mover. The primary data mover groups sets of the record updates and associated control information based upon a predetermined time interval, the primary data mover appending a prefix header to the record(updates thereby forming self describing record sets. The self describing record sets are transmitted to a remote secondary site wherein consistency groups are formed such that the record updates are ordered so that the record updates can be shadowed in an order consistent with the order the record updates cause write I/O operations at the primary site.

Abstract: A system for processing a plurality of tests or syntheses in parallel comprising a sample channel for moving samples into a microlaboratory array of a plurality of wells connected by one or more channels for the testing-or synthesis of samples, a station for housing the array and an optical system comprising at least one light source and at least one light detector for measuring the samples in the array, and a means of electrically connecting said array to an apparatus capable of monitoring and controlling the flow of fluids into the array. Samples are loaded from a common loading channel into the array, processed in the wells and measurements taken by the optical system. The array can process many samples, or synthesize many compounds in parallel, reducing the time required for such processes. Etching from both sides of a substrate using patterned photoresist and metal layers to form a network of capillary channels for separately transporting a plurality of different liquids.

Abstract: Methods are provided for synthesizing a plurality of compounds in parallel. The methods use cross-over channels for moving samples from a reservoir of starting materials into a plurality of wells. The movement is achieved, for example, using an electrokinetic pump.

Abstract: Copolymers of ethylene with such monomers as an alkyl acrylate and carbon monoxide or with vinyl acetate alone are blended with a thermoplastic block-polyester elastomer and a tackifier to produce thermally stable, hot-melt adhesive compositions which adhere well to polyvinyl chloride and which retain adhesivity at elevated temperatures. Fillers, plasticizers and compatible waxes may also be present in the composition.