Abstract: Compounds of general formula (I): (I) wherein R1, R2, R3, R4, R5, Y and Z are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: An optical fiber is provided that includes a core region, a cladding region having a radius less than about 62.5 microns; a polymer coating comprising a high-modulus layer and a low-modulus layer, wherein a thickness of the low-modulus inner coating layer is in a range of 4 microns to 20 microns, the modulus of the low-modulus inner coating layer is less than or equal to about 0.35 MPa, a thickness of the high-modulus coating layer is in a range of 4 microns to 20 microns, the modulus of the high-modulus inner coating layer is greater than or equal to about 1.6 GPa, and wherein a puncture resistance of the optical fiber is greater than 20 g, and wherein a microbend attenuation penalty of the optical fiber is less than 0.

Abstract: An optical fiber is provided that includes a core region, a cladding region having a radius less than about 62.5 microns; a polymer coating comprising a high-modulus layer and a low-modulus layer, wherein a thickness of the low-modulus inner coating layer is in a range of 4 microns to 20 microns, the modulus of the low-modulus inner coating layer is less than or equal to about 0.35 MPa, a thickness of the high-modulus coating layer is in a range of 4 microns to 20 microns, the modulus of the high-modulus inner coating layer is greater than or equal to about 1.6 GPa, and wherein a puncture resistance of the optical fiber is greater than 20 g, and wherein a microbend attenuation penalty of the optical fiber is less than 0.03 dB/km, and wherein an outer diameter of the coated optical fiber is less than or equal to 175 microns.

Abstract: Systems and methods for transaction/file-based management of a plurality of processes associated with various jobs are provided. Through the management of discrete applications, a file distribution manager/scheduler orchestrates automated execution of different types of jobs. The processes executed for the various processes can vary based on job type, or other parameters.

Abstract: The present disclosure relates to a thin coated optical fiber that enables connector assembly without stripping the optical fiber. In particular, the thin coating comprises a hard coating, a dye concentrate, and an adhesion promoter. The formulation of the coating promotes adhesion to a glass cladding of the optical fiber and to a ferrule bore (into which the optical fiber is inserted) by not causing silane decomposition of the coating. Moreover, the coating is colored to enable, among other things, fiber identification within a connector. The thin coated optical fibers exhibit good mechanical and optical performance properties as discussed herein.

Abstract: Systems and methods for transaction/file-based management of a plurality of processes associated with various jobs are provided. Through the management of discrete applications, a file distribution manager/scheduler orchestrates automated execution of different types of jobs. The processes executed for the various processes can vary based on job type, or other parameters.

Abstract: An optical fiber is provided that includes a core region, a cladding region having a radius less than about 62.5 microns; a polymer coating comprising a high-modulus layer and a low-modulus layer, wherein a thickness of the low-modulus inner coating layer is in a range of 4 microns to 20 microns, the modulus of the low-modulus inner coating layer is less than or equal to about 0.35 MPa, a thickness of the high-modulus coating layer is in a range of 4 microns to 20 microns, the modulus of the high-modulus inner coating layer is greater than or equal to about 1.6 GPa, and wherein a puncture resistance of the optical fiber is greater than 20 g, and wherein a microbend attenuation penalty of the optical fiber is less than 0.

Abstract: A composite has repeating domains of an inorganic glass and a polymer, such that the inorganic glass and the polymer each have a glass transition temperature (Tg) or softening temperature of less than 450° C., and at least 50% of the inorganic glass domains have a length of less than 30 ?m as measured along at least one cross-sectional dimension.

Abstract: Processing is provided for operating an in-memory database, wherein transaction data is stored by a persistence buffer in an FIFO queue, and update processor subsequently: waits for a trigger; extracts the last transactional data associated with a single transaction of the in-memory database from the FIFO memory queue; determines if the transaction data includes updates to data fields in the in-memory database which were already processed; and if not, then stores the extracted transaction data to a store queue, remembering the fields updated in the in-memory database, or otherwise updates the store queue with the extracted transaction data. The process continues until the extracting is complete, and the content of the store queue is periodically written into a persistent storage device.

Abstract: Systems and methods for transaction/file-based management of a plurality of processes associated with various jobs are provided. Through the management of discrete applications, a file distribution manager/scheduler orchestrates automated execution of different types of jobs. The processes executed for the various processes can vary based on job type, or other parameters.

Abstract: A valvetrain for an internal combustion engine of the type that has a combustion chamber, a moveable valve having a seat formed in the combustion chamber, and a camshaft includes a rocker arm assembly, a pivot providing a fulcrum for a rocker arm of the rocker arm assembly, and a latch assembly. An electrical device mounted to the rocker arm assembly receives power or communicates through a circuit that includes an electrical connection formed by abutment between surfaces of two distinct parts. The rocker arm assembly is operative to move one of the two abutting surfaces relative to the other in response to actuation of the cam follower. Forming an electrical connection through abutting surfaces that are free to undergo relative motion may reduce or eliminate the need to run wires to a mobile portion of the rocker arm assembly.

Abstract: Systems and methods for transaction/file-based management of a plurality of processes associated with various jobs are provided. Through the management of discrete applications, a file distribution manager/scheduler orchestrates automated execution of different types of jobs. The processes executed for the various processes can vary based on job type, or other parameters.

Abstract: An organic-inorganic composite, including: a discontinuous phase having a plurality of adjacent and similarly oriented fibers of an inorganic material; and a continuous organic phase having a thermoplastic polymer, such that the continuous organic phase surrounds the plurality of adjacent and similarly oriented fibers of the inorganic material, and the organic-inorganic composite is a plurality of adjacent and similarly oriented fibers of inorganic material contained within a similarly oriented host fiber of the thermoplastic polymer. Also disclosed are methods of making and using the composite.

Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.

Abstract: A valvetrain for an internal combustion engine of the type that has a combustion chamber, a moveable valve having a seat formed in the combustion chamber, and a camshaft includes a rocker arm assembly, a pivot providing a fulcrum for a rocker arm of the rocker arm assembly, and a latch assembly. An electrical device mounted to the rocker arm assembly receives power or communicates through a circuit that includes an electrical connection formed by abutment between surfaces of two distinct parts. The rocker arm assembly is operative to move one of the two abutting surfaces relative to the other in response to actuation of the cam follower. Forming an electrical connection through abutting surfaces that are free to undergo relative motion may reduce or eliminate the need to run wires to a mobile portion of the rocker arm assembly.

Abstract: An internal combustion engine includes a cam-actuated rocker arm assembly with a solenoid-actuated latch that provides for cylinder deactivation or variable valve actuation. The solenoid has an inductance that varies significantly in relation to the position of a latch pin as it translates between latching and non-latching configurations. A sensor is positioned to monitor a current or a voltage in a circuit that includes the solenoid. Diagnostic information relating to the operation of the rocker arm assembly is determined by comparing data collected from the sensor over a first period to data collected from the sensor over a second period.

Abstract: A valvetrain includes a rocker arm assembly having a rocker arm and an electromagnetic latch assembly. A magnet of the latch assembly is housed within a chamber formed by the rocker arm. The chamber may be a retrofit hydraulic chamber. The magnet may be an electromagnet or a permanent magnet. A flux shifting bi-stable latch provides a sufficiently compact design. Isolation of the magnet within the rocker arm chamber may provide protection from metal particles carried by oil in an operating environment for the rocker arm assembly.

Abstract: A valvetrain for an internal combustion engine of the type that has a combustion chamber, a moveable valve having a seat formed in the combustion chamber, and a camshaft includes a rocker arm assembly, a pivot providing a fulcrum for a rocker arm of the rocker arm assembly, and a latch assembly. An electrical device mounted to the rocker arm assembly receives power or communicates through a circuit that includes an electrical connection formed by abutment between surfaces of two distinct parts. The rocker arm assembly is operative to move one of the two abutting surfaces relative to the other in response to actuation of the cam follower. Forming an electrical connection through abutting surfaces that are free to undergo relative motion may reduce or eliminate the need to run wires to a mobile portion of the rocker arm assembly.