Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.

Abstract: An insert apparatus for installing a transducer assembly in a sensor port of a flow cell is disclosed. The transducer assembly is installed in the cavity of the insert body without the use of glues or adhesives to bond the transducer assembly to the cavity.

Abstract: Flowable pharmaceutical depots are described. The flowable pharmaceutical depot includes a polyester, such as a polylactic acid or a poly(trimethylene carbonate) endcapped with a primary alcohol and a pain relieving therapeutic agent, such as a post operative pain relieving therapeutic agent. Method of making and using the same are also described.

Abstract: An apparatus and method for determining temperature is disclosed. An ultrasonic signal is generated that propagates through a buffer and a portion of the signal is reflected at an interface. A time of flight is measured between generating the ultrasonic signal and detecting the reflected portion. The temperature is determined based on the time of flight of the reflected signal.

Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.

Abstract: An apparatus and method for installing or removing a cable is disclosed. A cable tool includes a cable channel with two channels having different channel openings for receiving or releasing the cable. The first end of the cable channel has a smaller channel opening and an arm that can be used to remove the cable and disconnect a connector on the end of the cable from a sensor.

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

Abstract: An apparatus configured for insertion into a sensor port of a flow cell is disclosed. The apparatus includes an insert body, a sensor located in the cavity of the insert body, and an insert body holding nut and a sensor holding nut threaded to the interior surface of the sensor port.

Abstract: A system and method for alerting operators of mobile equipment to the presence of people in monitored areas around the periphery of the mobile equipment they are operating is provided. The system includes an RFID detection system which is installed on the mobile equipment and alerts the operator to the presence of people wearing Personal Protection Equipment containing RFID safety tags. The system also includes a tag programming system which allows RFID safety tags to be created. The system also includes a tag testing system which allows a person to test the functionality of the RFID safety tags contained in the personal safety equipment they are wearing. The system also includes RFID personal safety equipment such as 3D safety vests and RFID hardhats which contains RFID safety tags. The 3D safety vests also include enhanced 3D visual markings.

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

Abstract: A flow cell for a plurality of sensor assemblies to communicate with a flow meter for measuring characteristics. The flow cell includes a sensor body with a sensor body bore extending through the sensor body. The flow cell also includes a sensor body quadrant extending outwardly from the sensor body bore on a side of the flow cell, wherein the sensor body quadrant intersects the sensor body bore. A plurality of sensor ports extend through the sensor body quadrant to provide openings from the exterior of the flow cell to the sensor body bore in which sensor assemblies can be inserted. A cable channel extends internally within the sensor body quadrant at least from the plurality of sensor ports to an access port on the exterior of the flow cell for routing cables from the sensor ports to communicate with the flow meter.

Abstract: The present invention relates to compounds of formula (I) wherein: R1 and R2 are each independently H, alkyl or haloalkyl; R3 and R4 are each independently H, alkyl, haloalkyl or aryl; R5 is alkyl or cycloalkyl or cycloalkyl-alkyl, each of which may be optionally substituted with one or more OH groups; R6 is selected from cyclopropylamino, cyclopropylmethylamino, cyclobutylamino, cyclobutylmethylamino and where one of X, Y and Z is N and the remainder are CR9; R7, R8 and each R9 are independently H, alkyl or haloalkyl, wherein at least one of R7, R8 and each R9 is other than H. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (I), and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.

Abstract: Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C?O)—, —(C?S)—, —SO.sub.

Abstract: A system and method for alerting operators of mobile equipment to the presence of people in monitored areas around the periphery of the mobile equipment they are operating is provided. The system includes an RFID detection system which is installed on the mobile equipment and alerts the operator to the presence of people wearing Personal Protection Equipment containing RFID safety tags. The system also includes a tag programming system which allows RFID safety tags to be created. The system also includes a tag testing system which allows a person to test the functionality of the RFID safety tags contained in the personal safety equipment they are wearing. The system also includes RFID personal safety equipment such as 3D safety vests and RFID hardhats which contains RFID safety tags. The 3D safety vests also include enhanced 3D visual markings.

Abstract: An insert apparatus for installing a transducer assembly in a sensor port of a flow cell is disclosed. The transducer assembly is installed in the cavity of the insert body without the use of glues or adhesives to bond the transducer assembly to the cavity.

Abstract: Isoxazoles of formula (A) or (B) are inhibitors of HSP90 activity, and useful for treatment of, for example cancers: wherein R1, is a group of formula (IA): —Ar1-(Alk1)p-(Z)r-(Alk2)s-Q, wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C6 alkylene or C2-C6 alkenylene radicals, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C?O)—, —(C?S)—, —SO.sub.

Abstract: Isoxazoles of formula (A) or (B) wherein R1 is a group of formula (IB) The isoxazoles are inhibitors of HSP90 activity, and useful for the treatment of, for example, cancers.

Abstract: A flow cell that includes a sensor body with internal cable channels for routing cables from the sensor ports to communicate with a flow meter is disclosed.