Patents by Inventor Edward Moler

Edward Moler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENOMIC SEQUENCING SELECTION SYSTEM
    Publication number: 20210313011
    Abstract: The systems and methods discussed herein can calculate sequencing statistics such as coverage depth for sequencing data. The present solution can determine variant frequencies and identify clinically relevant variants. The present solution can read BAM and VCF input files and Phred scaled quality scores. The present solution can select relatively high quality reads based on the quality scores and can calculate reference and alternative allele counts for SNPs, insertions and deletions (INDELs), and structural variants.
    Type: Application
    Filed: October 16, 2019
    Publication date: October 7, 2021
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Anindya Bhattacharya, Anna Gerasimova, Quoclinh Nguyen, Christopher Elzinga, Edward Moler
  • Effects of Inhibitors of FGFR3 on Gene Transcription
    Publication number: 20120149714
    Abstract: Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly.
    Type: Application
    Filed: February 21, 2012
    Publication date: June 14, 2012
    Inventors: Carla Heise, Esther Masih-Khan, Edward Moler, Michael Rowe, Keith Stewart, Suzanne Trudel
  • Effects of inhibitors of FGFR3 on gene transcription
    Patent number: 8158360
    Abstract: Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: April 17, 2012
    Assignee: Novartis AG
    Inventors: Carla Heise, Esther Masih-Khan, Edward Moler, Michael Rowe, Keith Stewart, Suzanne Trudel
  • SEMA4D in cancer diagnosis, detection and treatment
    Patent number: 7919246
    Abstract: This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the SEM A4D gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the SEMA4D gene.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: April 5, 2011
    Assignees: Novartis Vaccines and Diagnostics, Inc., Sagres Discovery, Inc.
    Inventors: Albert Lai, Abdallah Fanidi, Robert Booher, Christin Tse, Xie Xu, Guoying Yu, Edward Moler, Michael Rowe
  • BIOMARKERS OF TARGET MODULATION, EFFICACY, DIAGNOSIS AND/OR PROGNOSIS FOR RAF INHIBITORS
    Publication number: 20100004253
    Abstract: Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to Raf kinase inhibition, are measured and identifications or adjustments may be made accordingly.
    Type: Application
    Filed: September 19, 2007
    Publication date: January 7, 2010
    Inventors: Natasha Aziz, Edward Moler, Darrin Stuart, Carla Heise, Kim Aardelen
  • ADAM10 in Cancer Diagnosis, Detection and Treatment
    Publication number: 20090297507
    Abstract: This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the ADAM10 gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the ADAM10 gene.
    Type: Application
    Filed: April 7, 2006
    Publication date: December 3, 2009
    Inventors: Albert Lai, Abdallah Fanidi, Robert Booher, Christin Tse, Xie Xu, Guoying Yu, Edward Moler, Michael Rowe
  • CACNA1E in Cancer Diagnosis, Detection and Treatment
    Publication number: 20090214536
    Abstract: This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the CACNA1E gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the CACNA1E gene.
    Type: Application
    Filed: April 7, 2006
    Publication date: August 27, 2009
    Inventors: Guoying Yu, Edward Moler, Michael Rowe, Christin Tse, Xie Xu
  • SEMA4D in Cancer Diagnosis, Detection and Treatment
    Publication number: 20090104193
    Abstract: This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the SEM A4D gene or proteins encoded by this gene. The invention also provides methods and molecules for upregulating or downregulating the SEMA4D gene.
    Type: Application
    Filed: April 7, 2006
    Publication date: April 23, 2009
    Inventors: Albert Lai, Abdallah Fanidi, Robert Booher, Christin Tse, Xie Xu, Guoying Yu, Edward Moler, Michael Rowe
  • Effects of Inhibitors of Fgfr3 on Gene Transcription
    Publication number: 20090048266
    Abstract: Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly.
    Type: Application
    Filed: December 7, 2006
    Publication date: February 19, 2009
    Applicant: NOVARTS AG
    Inventors: Carla Heise, Esther Masih-Khan, Edward Moler, Michael Rowe, Keith Stewart, Suzanne Trudel
  • Methods for predicting the course of a malignant disease
    Publication number: 20090036321
    Abstract: The present invention relates to methods of predicting the course of malignant disease and more specifically to methods which use SERPINE2 as a prognostic indicator of disease in cancer patients.
    Type: Application
    Filed: June 3, 2004
    Publication date: February 5, 2009
    Applicant: Chiron Corporation
    Inventors: Edward Moler, Filippo Randazzo, Michael Rowe
  • Novel compositions and methods in cancer
    Publication number: 20070237770
    Abstract: This invention is in the field of cancer-associated (CA) genes. Specifically it relates to methods for detecting and diagnosing cancer or the likelihood of developing cancer based on the presence or absence of expression of certain genes or proteins encoded by those genes. The invention also provides methods and molecules for upregulating or downregulating these cancer-associated genes.
    Type: Application
    Filed: April 12, 2006
    Publication date: October 11, 2007
    Inventors: Albert Lai, Abdallah Fanidi, Robert Booher, Guoying Yu, Edward Moler, Michael Rowe
  • Novel compositions and methods in cancer
    Publication number: 20070071757
    Abstract: This invention is in the field of cancer-associated (CA) genes. Specifically it relates to methods for detecting and diagnosing cancer or the likelihood of developing cancer based on the presence or absence of expression of PRDM11 or TBX21 or proteins encoded by those genes. The invention also provides methods and molecules for upregulating or downregulating these cancer-associated genes.
    Type: Application
    Filed: April 19, 2006
    Publication date: March 29, 2007
    Inventors: Guoying Yu, Edward Moler, Michael Rowe
  • Gene products differentially expressed in cancerous cells III
    Publication number: 20070010469
    Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
    Type: Application
    Filed: September 22, 2004
    Publication date: January 11, 2007
    Inventors: Vivien Chan, Jaime Escobedo, Pablo Garcia, Rhonda Hansen, Joerg Kaufmann, Giulia Kennedy, George Lamson, Edward Moler, Filippo Randazzo, Christoph Reinhard, Julie Sudduth-Klinger