Abstract: The disclosure features methods for treating hypophosphatasia (HPP) in a patient (e.g., an adult having HPP, such as an adult having pediatric-onset HPP, or an adolescent having HPP) exhibiting decreased pyrophosphate (PPi) or pyridoxal 5?-phosphate (PLP) concentrations in, e.g., a plasma sample, physical impairments, or decreased walking ability by administering a soluble alkaline phosphatase (sALP) to the patient.

Abstract: The disclosure features methods for treating hypophosphatasia (HPP) in a patient (e.g., an adult having HPP, such as an adult having pediatric-onset HPP, or an adolescent having HPP) exhibiting decreased pyrophosphate (PPi) or pyridoxal 5?-phosphate (PLP) concentrations in, e.g., a plasma sample, physical impairments, or decreased walking ability by administering a soluble alkaline phosphatase (sALP) to the patient.

Abstract: A system, method and apparatus for determining a support entitlement level are provided. A product support request is received from a customer. A technical support identification (TSID) is also received from the customer. The TSID is validated and classified. The TSID may be classified into at least one of several classifications. One of the classifications is a contract classification. At least one of several support levels are assigned to the classified TSID. The assigned support level corresponds to the TSID classification. The TSID is received, validated, classified and the support level assigned before a product support agent is notified of the product support request. Then the assigned support level is delivered.