Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: There is presented a wearable device (200) and corresponding system and method for sensing a substance ingested by a subject, for instance an intoxicating substance. The wearable device has a sensing arrangement extending between a first port (205a) and a second port (205b). The sensing arrangement includes two chambers, a pump and two flow-control devices. The first chamber is adapted to collect gas from a skin region of the subject. The second chamber has a sensor to sense the substance. The first flow-control device is provided at the first port (205a) and the second flow-control device is provided at the second port (205b). A controller is provided to control the pump and the sensor. The controller is operable in a first phase to sense a first gas sample from ambient environment, and a second phase to sense a second gas sample from a skin region of the subject.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A firearm accessory may include an elongate body having an end that is positioned adjacent to a firing end of a barrel of a firearm. The firearm accessory may also include a piston assembly that is located at least partially within the elongate body. A first end of the piston assembly may be configured to be secured to the barrel of the firearm. The piston assembly may also include an indexing ring positioned at a second end of the piston assembly. The elongate body and the piston assembly may be rotatable relative to one another about a longitudinal axis that extends from the first end of the piston assembly to the second end of the piston assembly. The firearm accessory may also include an orientation assembly that includes a pawl and a selector component for selectively disengaging the pawl with the indexing ring of the piston assembly.

Abstract: A system for delivering oxygen comprises an oxygen source; a ventilator operatively connected to the oxygen source to receive a supply of oxygen therefrom; a valve having a) an open position in which the ventilator receives the supply of oxygen from the oxygen source and b) a closed position in which the ventilator is not in fluid communication with the oxygen source; a sensor configured to measure breath flow information for the patient; and a computer system to: determine a volume of gas delivered to the patient during a breath cycle of the patient and an inspiratory volume of gas delivered to the patient during an inspiration phase of the breath cycle by using the breath flow information; and provide input to the valve based on the determined volumes, the provided input causing a movement of the valve between the open and the closed positions.

Abstract: A system for delivering oxygen comprises an oxygen source; a ventilator operatively connected to the oxygen source to receive a supply of oxygen therefrom; a valve having a) an open position in which the ventilator receives the supply of oxygen from the oxygen source and b) a closed position in which the ventilator is not in fluid communication with the oxygen source; a sensor configured to measure breath flow information for the patient; and a computer system to: determine a volume of gas delivered to the patient during a breath cycle of the patient and an inspiratory volume of gas delivered to the patient during an inspiration phase of the breath cycle by using the breath flow information; and provide input to the valve based on the determined volumes, the provided input causing a movement of the valve between the open and the closed positions.

Abstract: A system for configuring generic maintenance activity scheduling is provided. For example, user input may help define a maintenance process for a plurality of mobile drive units of the physical workspace. The maintenance process may be defined through a configuration of activity templates and input templates. Input may be received to configure maintenance activities and the system may automatically correlate failure rules with the activity template. The system may generate the configurable electronic instructions for the mobile drive units and transmit them with the failure rules, if generated, to one or more mobile drive units of the physical workspace. When the one or more mobile device units receive the configurable electronic instruction, the mobile drive units may operate in accordance with the configurable electronic instruction.

Abstract: A breathing apparatus including a case containing a chemical for generating oxygen and a monitoring circuit in the case is disclosed. The monitoring circuit includes multiple sensors that sense parameters within the case relevant to an operational status of the breathing apparatus, and a controller to receive signals from the sensors and to produce an output signal indicating the operational status of the breathing apparatus. A method for monitoring a breathing apparatus is also disclosed. The method includes using multiple sensors within a case of a breathing apparatus to sense parameters relevant to an operational status of the breathing apparatus, and processing signals from the sensors to produce an output signal representative of the operational status of the breathing apparatus. The sensors may include humidity, impact, pressure and temperature sensors.

Abstract: A breathing apparatus including a case containing a chemical for generating oxygen and a monitoring circuit in the case is disclosed. The monitoring circuit includes multiple sensors to that sense parameters within the case relevant to an operational status of the breathing apparatus, and a controller to receive signals from the sensors and to produce an output signal indicating the operational status of the breathing apparatus. A method for monitoring a breathing apparatus is also disclosed. The method includes using multiple sensors within a case of a breathing apparatus to sense parameters relevant to an operational status of the breathing apparatus, and processing signals from the sensors to produce an output signal representative of the operational status of the breathing apparatus. The sensors may include humidity, impact, pressure and temperature sensors.

Abstract: The present disclosure relates to inclusion of a non-contact antenna. The non-contact antenna can allow a variety of antennas to be used on a hearing assistance device and can overcome issues associated with mounting an antenna internal to the case of a heating assistance device. A non-contact antenna may include a proximity coupled antenna, such as an antenna mounted on a hearing assistance device case (external to the case) near a feed line that will transfer energy between the antenna and an SMD internal to the case. A non-contact antenna may include an aperture coupled antenna, such as an antenna mounted external to the case on an antenna substrate, where the antenna substrate is on a feed substrate with a feed line, and where there is an aperture in a ground plane.

Abstract: Multiple antennas at the receiver and/or transmitter are commonly used in wireless communications systems to provide diversity in order reduce fading and other effects brought about by multi-path propagation. Due to the size of hearing aids and the wavelengths of the frequencies used for communication, it is difficult to achieve what is called spatial diversity by disposing the multiple antennas at different locations. Described herein are techniques for providing polarization diversity in hearing aids using antennas with different polarizations and applying the appropriate phase shifts to the received and/or transmitted signals to improve the signal quality.

Abstract: The present disclosure relates to inclusion of a non-contact antenna. The non-contact antenna can allow a variety of antennas to be used on a hearing assistance device and can overcome issues associated with mounting an antenna internal to the case of a hearing assistance device. A non-contact antenna may include a proximity coupled antenna, such as an antenna mounted on a hearing assistance device case (external to the case) near a feed line that will transfer energy between the antenna and an SMD internal to the case. A non-contact antenna may include an aperture coupled antenna, such as an antenna mounted external to the case on an antenna substrate, where the antenna substrate is on a feed substrate with a feed line, and where there is an aperture in a ground plane.

Abstract: Left/Right (L/R) hearing assistance device (HA) symmetrical performance of the antenna is highly desired when using the same HA design for both the left and the right ears. Physical symmetry and loading of the antenna, both internal and external to the HA, is usually not possible because the antenna should avoid the microphone, battery, and switch locations within the HA. Described herein are antenna structures, hearing assistance devices with integrated antennas, and methods of wireless communication in hearing assistance devices which create symmetrical (L/R) antenna performance with physically asymmetrical antenna designs.

Abstract: Multiple antennas at the receiver and/or transmitter are commonly used in wireless communications systems to provide diversity in order reduce fading and other effects brought about by multi-path propagation. Due to the size of hearing aids and the wavelengths of the frequencies used for communication, it is difficult to achieve what is called spatial diversity by disposing the multiple antennas at different locations. Described herein are techniques for providing polarization diversity in hearing aids using antennas with different polarizations and applying the appropriate phase shifts to the received and/or transmitted signals to improve the signal quality.

Abstract: Wireless communication antennas for hearing assistance devices are provided. In various embodiments, a hearing assistance device includes a housing configured to be worn on or behind the ear, hearing assistance electronics enclosed in the housing, an ear mold configured to be worn in the ear, a sound tube configured to connect to the earmold and to transmit an acoustic output to the earmold, and an earhook configured to connect the housing to the sound tube. At least one of the earmold, the sound tube, and the earhook includes a conductive polymer forming at least a portion of an antenna for wireless communication, in various embodiments.

Abstract: The present disclosure relates to inclusion of a non-contact antenna. The non-contact antenna can allow a variety of antennas to be used on a hearing assistance device and can overcome issues associated with mounting an antenna internal to the case of a hearing assistance device. A non-contact antenna may include a proximity coupled antenna, such as an antenna mounted on a hearing assistance device case (external to the case) near a feed line that will transfer energy between the antenna and an SMD internal to the case. A non-contact antenna may include an aperture coupled antenna, such as an antenna mounted external to the case on an antenna substrate, where the antenna substrate is on a feed substrate with a feed line, and where there is an aperture in a ground plane.

Abstract: Left/Right (L/R) hearing assistance device (HA) symmetrical performance of the antenna is highly desired when using the same HA design for both the left and the right ears. Physical symmetry and loading of the antenna, both internal and external to the HA, is usually not possible because the antenna should avoid the microphone, battery, and switch locations within the HA. Described herein are antenna structures, hearing assistance devices with integrated antennas, and methods of wireless communication in hearing assistance devices which create symmetrical (L/R) antenna performance with physically asymmetrical antenna designs.

Abstract: A breathing apparatus comprising a case containing a chemical for generating oxygen and a monitoring circuit in the case is disclosed. The monitoring circuit includes multiple sensors configured to sense parameters within the case relevant to an operational status of the breathing apparatus, and a controller configured to receive signals from the sensors and to produce an output signal indicating the operational status of the breathing apparatus. A method for monitoring a breathing apparatus is also disclosed. The method includes using multiple sensors within a case of a breathing apparatus to sense parameters relevant to an operational status of the breathing apparatus, and processing signals from the sensors to produce an output signal representative of the operational status of the breathing apparatus. The sensors may include humidity, impact, pressure and temperature sensors.

Abstract: A device for automatically delivering a drug to a user and method thereof are disclosed. The device (10, 20, 70, 110) provides a connector to which a vial (12, 50, 60, 100, 130, 202) containing the drug is removably connected and situated thereto in a substantially inverted position. When commanded by the user, the device (10, 20, 70, 110) starts a reconstitution process to automatically create a reconstituted drug, and provides an indication that the reconstitution process is complete such that the vial (12, 50, 60, 100, 130, 202) may be removed from the connector (22, 72,112). After disposing the device (10, 20, 70, 110) on the user, the device (10, 20, 70, 110) can automatically deliver the reconstituted drug to the user when further commanded by the user.

Abstract: A framework and graphical user interface for sharing, comparing, and displaying resource usage data provide for the ability to construct an extensible framework for configuring a graphical user interface (GUI) containing resource usage data pertaining to one or more entities. In various embodiments, the framework enables competitions and comparisons, event tagging, carbon offsetting, or any combination thereof. The framework also makes the GUI available by various means, including Internet distribution. The GUI may take the form of websites, standalone applications, desktop widgets, blog or social networking applications, and the like.