Patents by Inventor Edward Neuwelt

Edward Neuwelt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR REDUCING OTOTOXICITY IN PEDIATRIC PATIENTS RECEIVING PLATINUM-BASED CHEMOTHERAPY
    Publication number: 20230390330
    Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
    Type: Application
    Filed: August 22, 2023
    Publication date: December 7, 2023
    Applicants: Oregon Health & Science University, The United States Govenment Department of Veterans Affairs
    Inventor: Edward A. Neuwelt
  • Method for Reducing Ototoxicity in Pediatric Patients Receiving Plantinum-Based Chemotherapy
    Publication number: 20230270776
    Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
    Type: Application
    Filed: May 9, 2023
    Publication date: August 31, 2023
    Applicants: Oregon Health & Science University, The United States Government as represented by The Department of Veterans Affairs
    Inventor: Edward A. Neuwelt
  • Morpholino oligonucleotides useful in cancer treatment
    Patent number: 11679121
    Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: June 20, 2023
    Assignees: United States Government As Represented By The Department of Veterans Affairs, Oregon Health & Science University
    Inventors: Prakash Ambady, Jeffrey Wu, Edward Neuwelt
  • METHOD FOR REDUCING OTOTOXICITY IN PEDIATRIC PATIENTS RECEIVING PLATINUM-BASED CHEMOTHERAPY
    Publication number: 20220280560
    Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
    Type: Application
    Filed: May 9, 2022
    Publication date: September 8, 2022
    Applicant: Oregon Health & Science University
    Inventor: Edward A. Neuwelt
  • Morpholino Oligonucleotides Useful In Cancer Treatment
    Publication number: 20210106608
    Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.
    Type: Application
    Filed: December 7, 2020
    Publication date: April 15, 2021
    Inventors: Prakash Ambady, Jeffrey Wu, Edward Neuwelt
  • Morpholino oligonucleotides useful in cancer treatment
    Patent number: 10857174
    Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: December 8, 2020
    Assignees: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Prakash Ambady, Jeffrey Wu, Edward Neuwelt
  • Method for reducing ototoxicity in pediatric patients receiving platinum-based chemotherapy
    Patent number: 10596190
    Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: March 24, 2020
    Assignee: Oregon Health & Science University
    Inventor: Edward A. Neuwelt
  • METHOD FOR REDUCING OTOTOXICITY IN PEDIATRIC PATIENTS RECEIVING PLATINUM-BASED CHEMOTHERAPY
    Publication number: 20200038436
    Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
    Type: Application
    Filed: April 15, 2019
    Publication date: February 6, 2020
    Inventor: Edward A. NEUWELT
  • Morpholino Oligonucleotides Useful In Cancer Treatment
    Publication number: 20200030357
    Abstract: Disclosed are morpholino oligonucleotides that can be used to silence expression of MGMT, pharmaceutical compositions that include said morpholino oligonucleotides, and methods of using said morpholino oligonucleotides in the treatment of cancer, particularly methods that involve the use of radiation to deliver said morpholino oligonucleotides.
    Type: Application
    Filed: July 25, 2019
    Publication date: January 30, 2020
    Inventors: Prakash Ambady, Jeffrey Wu, Edward Neuwelt
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20200000844
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: February 7, 2019
    Publication date: January 2, 2020
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • METHOD FOR REDUCING OTOTOXICITY IN PEDIATRIC PATIENTS RECEIVING PLATINUM-BASED CHEMOTHERAPY
    Publication number: 20190160094
    Abstract: Described herein is a method for eliminating or reducing ototoxicity in patients receiving a platinum based chemotherapeutic. In particular, are methods of reducing ototoxicity in a pediatric patient. The methods described herein include administering an effective amount of sodium thiosulfate to a patient in need thereof to reduce ototoxicity.
    Type: Application
    Filed: August 24, 2018
    Publication date: May 30, 2019
    Inventor: Edward A. NEUWELT
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20180289737
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: February 28, 2018
    Publication date: October 11, 2018
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20170182089
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: October 4, 2016
    Publication date: June 29, 2017
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • ADMINISTRATION OF A THIOL-BASED CHEMOPROTECTANT COMPOUND
    Publication number: 20160184353
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: July 29, 2015
    Publication date: June 30, 2016
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • METHODS FOR REDUCING TOXICITIES ASSOCIATED WITH MEDICAL PROCEDURES EMPLOYING RADIOGRAPHIC CONTRAST AGENTS
    Publication number: 20110046482
    Abstract: Improved methods of administration of thiol-based agents, such as NAC (N-acetylcysteine) and STS (sodium thiosulfate), are provided that protect against renal and other organ injury caused by diagnostic or therapeutic intra-arterial procedures which employ radiographic contrast agents.
    Type: Application
    Filed: August 16, 2007
    Publication date: February 24, 2011
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Edward A. Neuwelt, Leslie L. Muldoon
  • Administration of a thiol-based chemoprotectant compound
    Publication number: 20060177523
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: November 14, 2005
    Publication date: August 10, 2006
    Applicants: Oregon Health & Science University, Government of The United States, d/b/a The Department of Veterans Affairs
    Inventors: Edward Neuwelt, Leslie Muldoon, Michael Pagel
  • Administration of a thiol-based chemoprotectant compound
    Patent number: 7022315
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: April 4, 2006
    Assignees: Oregon Health & Science University, United States of America as represented by the Department of Veterans Affairs
    Inventors: Edward A. Neuwelt, Leslie Muldoon, Michael A. Pagel
  • Bone marrow protection with N-acetyl-L-cysteine
    Publication number: 20060020035
    Abstract: The present invention provides methods for preventing or ameliorating chemotherapeutic agent-induced bone marrow toxicity. These methods comprise administering an effective amount of N-acetyl-L-cysteine (L-NAC), alone or in combination with other agents, to a subject in need thereof. The present invention also provides compositions for preventing or ameliorating chemotherapeutic agent-induced bone marrow toxicity that comprises L-NAC.
    Type: Application
    Filed: March 11, 2005
    Publication date: January 26, 2006
    Applicant: Oregon Health & Science University
    Inventors: Edward Neuwelt, Leslie Muldoon
  • Use of thiol-based compositions in ameliorating mucosal injury
    Publication number: 20040198841
    Abstract: The present invention discloses a method of ameliorating mucosal injury in patients undergoing chemotherapy by the administration of a thiol-based compound or composition.
    Type: Application
    Filed: March 15, 2004
    Publication date: October 7, 2004
    Applicant: Oregon Health & Science University
    Inventor: Edward A. Neuwelt
  • Use of thiol-based compositions in treating chemotherapeutic agent-induced thrombocytopenia
    Publication number: 20040146585
    Abstract: The present invention provides methods for preventing or reducing chemotherapeutic agent-induced thrombocytopenia. These methods comprise administering an effective amount of a thiol-containing compound or composition (e.g., sodium thiosulfate and N-acetylcysteine) to a subject in need thereof.
    Type: Application
    Filed: October 31, 2003
    Publication date: July 29, 2004
    Applicant: Oregon Health & Science University
    Inventors: Edward A. Neuwelt, Leslie L. Muldoon