Patents by Inventor Edward Nolan

Edward Nolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7570992
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: August 4, 2009
    Assignee: Genetronics, Inc.
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Publication number: 20080115452
    Abstract: A prefabricated reinforced brick panel has a plurality of bricks arranged in a spaced-apart array with mortar between the bricks. The array comprises a number of superimposed rows of bricks. The bricks in each row are staggered relative to the bricks in each adjacent row of bricks. Each brick has a number of vertical through holes extending between a top and a bottom of the brick. These through holes are aligned in the array and vertical reinforcing bars are inserted into aligned holes and extend between a top and a bottom of the panel. Two offset vertical reinforcing bars pass through each brick. Transverse reinforcing bars are mounted in the mortar between rows of bricks.
    Type: Application
    Filed: November 2, 2007
    Publication date: May 22, 2008
    Inventor: Edward Nolan
  • Publication number: 20060224192
    Abstract: Improved devices and methods for performing electroporation-mediated delivery agents to cells is described. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
    Type: Application
    Filed: May 30, 2006
    Publication date: October 5, 2006
    Applicant: Genetronics, Inc.
    Inventors: Steve Dimmer, Gunter Hofmann, Daniel Holt, Gurvinder Nanda, Edward Nolan
  • Publication number: 20040147964
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: January 13, 2004
    Publication date: July 29, 2004
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Publication number: 20040092860
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: June 9, 2003
    Publication date: May 13, 2004
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Patent number: 6697669
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: February 24, 2004
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Patent number: 6678556
    Abstract: In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: January 13, 2004
    Assignee: Genetronics, Inc.
    Inventors: Edward Nolan, Dietmar P. Rabussay, Georg Widera, Lei Zhang
  • Patent number: 6654636
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: November 25, 2003
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Publication number: 20020099323
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: July 13, 1999
    Publication date: July 25, 2002
    Inventors: NAGENDU B. DEV, GUNTER A. HOFMANN, EDWARD NOLAN, DIETMAR P. RABUSSAY, ARNT TONNESSEN, GEORG WIDERA, LEI ZHANG
  • Patent number: 6424893
    Abstract: A mileage and fuel purchase monitoring device for vehicles including a data collecting system that is connected with an odometer of a truck or other motor vehicle. The data collecting system is preferably secured to a dashboard of the truck for easy access by the driver. The data collecting system is provided with a keyboard and a display for entering relevant information related to a planned trip to be made.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: July 23, 2002
    Inventors: Patrick Byrne, Edward Barnes, Edward Nolan
  • Patent number: 6412244
    Abstract: A prefabricated modular wall element (20) comprises a precast reinforced concrete wall panel (21) having a front face (24). A plurality of spaced-apart individual slabs (33) of stone or brick are partially embedded in the front face (24) of the panel (21) during casting of the panel (21) and project outwardly of the front face (24) with channels being formed between the slabs (33). The slabs are arranged on the front face (24) such that the front face (24) simulates a wall constructed of stone. A pair of spaced-apart support legs (38) are provided at a bottom (27) of the wall panel (21) for keying into a concrete foundation (42) to support the wall element (1) in an upright.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: July 2, 2002
    Inventor: Edward Nolan
  • Patent number: 6349840
    Abstract: A detachable ramp carrying system for moving containers including a pair of securement brackets coupled with the horizontal lower segments of opposed L-shaped brackets of the moving container. The securement brackets support the ramp thereon disposed below the closed lower end of the container.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: February 26, 2002
    Inventors: Patrick Byrne, Edward Nolan
  • Publication number: 20010047631
    Abstract: A prefabricated modular wall element (20) comprises a precast reinforced concrete wall panel (21) having a front face (24). A plurality of spaced-apart individual slabs (33) of stone or brick are partially embedded in the front face (24) of the panel (21) during casting of the panel (21) and project outwardly of the front face (24) with channels being formed between the slabs (33). The slabs are arranged on the front face (24) such that the front face (24) simulates a wall constructed of stone. A pair of spaced-apart support legs (38) are provided at a bottom (27) of the wall panel (21) for keying into a concrete foundation (42) to support the wall element (1) in an upright position.
    Type: Application
    Filed: September 3, 1999
    Publication date: December 6, 2001
    Inventor: EDWARD NOLAN