Abstract: Provided herein are methods of preventing or treating ocular viral, fungal, protozoa or bacterial infections. The method comprises administering ocular doses of a binding agent reactive against a virus, fungus, protozoa or bacteria, which, in one embodiment, is a pooled, human immunoglobulin preparation, such as, without limitation, those suitable for intravenous use, including Gammagard or other like products. Also provided are ocular dosage forms and dosing devices comprising the binding reagent.