Patents by Inventor Edward O. Stapley

Edward O. Stapley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotics-859A and production thereof
    Patent number: 4521408
    Abstract: The mixture, Antibiotics-859A and the production thereof is described. The Antibiotics-859A are produced by the controlled aerobic cultivation of Streptomyces griseoruber, ATCC 39068 in an aqueous nutrient medium. The Antibiotics-859A exhibit activity both in vitro and in vivo against gram negative and gram positive organisms including the genera: Diplococcus, Staphylococcus, Streptococcus, Pseudomonas and Salmonella.
    Type: Grant
    Filed: April 14, 1982
    Date of Patent: June 4, 1985
    Assignee: Merck & Co., Inc.
    Inventor: Edward O. Stapley
  • Antibiotics-875A and production thereof
    Patent number: 4427655
    Abstract: The Antibiotics-875A are obtained from the controlled aerobic cultivation of Streptomyces hygroscopicus ATCC 39067. The Antibiotics-875A show in vitro and in vivo activity against gram positive and gram negative organisms including the genera; Staphylococcus, Streptococcus, Aerobacter, Escherichia, Klebsiella, Parlacolobactrum, Pseudomonas and Salmonella.
    Type: Grant
    Filed: April 12, 1982
    Date of Patent: January 24, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Edward O. Stapley
  • Culture of Streptomyces cattleya
    Patent number: 4304867
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: January 3, 1978
    Date of Patent: December 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Cephalosporin antibiotics
    Patent number: 4302578
    Abstract: Disclosed are 7.beta.-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.
    Type: Grant
    Filed: February 16, 1971
    Date of Patent: November 24, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Edward O. Stapley, Justo M. Mata
  • Process for producing antibiotics by cultivation of Streptomyces flavogriseus
    Patent number: 4235967
    Abstract: The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: April 6, 1979
    Date of Patent: November 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Acetylthienamycin production
    Patent number: 4229534
    Abstract: The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antiobiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: October 21, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Process for producing antibiotics
    Patent number: 4168202
    Abstract: The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: July 8, 1977
    Date of Patent: September 18, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • N-acetyl thienamycin
    Patent number: 4165379
    Abstract: The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.
    Type: Grant
    Filed: August 25, 1977
    Date of Patent: August 21, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Antibiotics 890A.sub.1 and 890A.sub.3
    Patent number: 4162324
    Abstract: The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: August 25, 1977
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Antibiotics 890A.sub.2 and 890A.sub.5
    Patent number: 4141986
    Abstract: The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: February 27, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Patrick J. Cassidy, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
  • Antibiotics
    Patent number: 4081548
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: September 3, 1976
    Date of Patent: March 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Preparation of antibiotics by fermentation
    Patent number: 4036696
    Abstract: A fermentation process for preparing 7-methoxy substituted cephalosporins. The products are useful as antibiotics and exhibit activity against gram-negative and gram-positive bacteria.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: July 19, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward O. Stapley, Justo M. Mata
  • 7.beta.-(D-5-amino-5-carboxyvaleramido )-7-methoxy-3-substituted-3-cephem-4-carboxylic acid antibiotics
    Patent number: 4017487
    Abstract: Disclosed are 7.beta.-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substitutents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.
    Type: Grant
    Filed: October 4, 1974
    Date of Patent: April 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward O. Stapley, Justo M. Mata
  • Thienamycin production
    Patent number: 4006060
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: February 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Process for preparing 3-hydroxymethyl cephalosporins
    Patent number: 3985742
    Abstract: Disclosed are 7.beta.-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: October 12, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Edward O. Stapley, Justo M. Mata
  • Antibiotics
    Patent number: 3950357
    Abstract: The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: April 13, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Jean S. Kahan, Frederick M. Kahan, Edward O. Stapley, Robert T. Goegelman, Sebastian Hernandez
  • Synergistic combinations of phosphonomycin and bacteriostatic agents
    Patent number: 3935309
    Abstract: Pathogens are controlled by concomitant contact with a phosphonomycin antibiotic and a bacteriostatic chemotherapeutic compound by separate or simultaneous administration. The combined action is especially advantageous in contacting resistant microorganisms and other microorganisms which are oridinarily not controlled by contact with the individual chemotherapeutic agents.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: January 27, 1976
    Assignee: Merck & Co., Inc.
    Inventors: David Hendlin, Justo Martinez Mata, Sagrario Mochales Del Val, Edward O. Stapley