Patents by Inventor Edward Oldfield

Edward Oldfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070154569
    Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
    Type: Application
    Filed: July 9, 2004
    Publication date: July 5, 2007
    Applicants: The Govt. of the U.S.A. through The Dept. of Health and Human Services, The University of Alabama Research Foundation, Wake Forest University, Loma Linda University, The Board of Supervisors of Louisiana State University
    Inventors: Mark Gladwin, Alan Schechter, David Lefer, Rakesh Patel, Christian Hunter, Gordon Power, Daniel Kim-Shapiro, Ryszard Pluta, Edward Oldfield, Richard Cannon
  • Publication number: 20060073101
    Abstract: A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infulsed with the therapeutic agent and used to monitor the distribution of the therapeutic agent as it moves through the target tissue. The images obtained during delivery are used to confirm delivery of the therapeutic agent to the target tissue and to avoid exposure of tissue outside of the targeted area to the therapeutic agent. In addition, the signal intensity of the images may be used to confirm that the therapeutic agent has been delivered to the target tissue at a desired concentration.
    Type: Application
    Filed: September 24, 2003
    Publication date: April 6, 2006
    Inventors: Edward Oldfield, Russel Lonser, Kayban Garmestani, Martin Brechbiel
  • Publication number: 20020114780
    Abstract: The present invention provides a method of increasing the volume of distribution of a therapeutic agent in a tissue in a subject during localized delivery comprising administering to the tissue in the subject a therapeutic agent and a facilitating agent, whereby the inclusion of the facilitating agent increases the volume of distribution of the therapeutic agent in the tissue. The invention also provides a method of increasing the pharmacological activity of a therapeutic agent in a tissue in a subject during localized delivery, comprising administering to the tissue in the subject a therapeutic agent and a facilitating agent, whereby the inclusion of the facilitating agent increases the pharmacological activity of the therapeutic agent in the tissue.
    Type: Application
    Filed: November 30, 2001
    Publication date: August 22, 2002
    Inventors: Krys Bankiewicz, John Hamilton, Edward Oldfield, Heidi Phillips