Patents by Inventor Edward P. Bowman

Edward P. Bowman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to IL-17A
    Patent number: 8753843
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: June 17, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Leonard G. Presta, Edward P. Bowman
  • COMBINATION THERAPY FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20130287775
    Abstract: Methods and compositions are provided for the treatment of immune disorders, such as autoimmune diseases, or cancers, involving combination therapy with agents that inhibit the development or maintenance of Th17 cells. Treatment regimens are provided in which an antagonist of a pro-inflammatory cytokine is administered for a time sufficient to alleviate signs and symptoms of an acute phase flare-up of the autoimmune disease, or cancer, and treatment with an antagonist of IL-23 is continued for a longer time to prevent recurrence of the acute event. Antagonists of PGE2 and CD161 are also disclosed for use in treatment of autoimmune, inflammatory and proliferative disorders.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 31, 2013
    Inventors: Edward P. Bowman, Daniel J. Cua, Robert A. Kastelein, Kathy L. Miller, Melanie A. Kleinschek, Kristian S. Bak-Jensen, Katia Boniface, Brent S. McKenzie, Rene de Waal Malefyt
  • Pathogenic TH17 Cells; related reagents and methods
    Publication number: 20120156699
    Abstract: Methods and compositions are provided for the treatment of immune disorders, such as autoimmune diseases, or cancers, involving combination therapy with agents that inhibit the development or maintenance of Th17 cells. Treatment regimens are provided in which an antagonist of a pro-inflammatory cytokine is administered for a time sufficient to alleviate signs and symptoms of an acute phase flare-up of the autoimmune disease, or cancer, and treatment with an antagonist of IL-23 is continued for a longer time to prevent recurrence of the acute event. Antagonists of PGE2 and CD161 are also disclosed for use in treatment of autoimmune, inflammatory and proliferative disorders.
    Type: Application
    Filed: February 24, 2012
    Publication date: June 21, 2012
    Applicant: Schering Corporation
    Inventors: Edward P. Bowman, Daniel J. Cua, Robert A. Kastelein, Kathy Lynn Miller, Melanie A. Kleinschek, Katia Boniface, Kristian S. Bak-Jensen, Brent S. McKenzie, Rene de Waal Malefyt
  • Antibodies to IL-17A
    Patent number: 8193319
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: June 5, 2012
    Assignee: Schering Corporation
    Inventors: Leonard G. Presta, Edward P. Bowman
  • USES OF MAMMALIAN CYTOKINE; RELATED REAGENTS
    Publication number: 20120052044
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Application
    Filed: November 1, 2011
    Publication date: March 1, 2012
    Applicant: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • Methods of treating cutaneous ulcers and grafts using agonist antibodies to IL-23 receptor
    Patent number: 8062634
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: November 22, 2011
    Assignee: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • Uses of Mammalian Cytokine; Related Reagents
    Publication number: 20110135597
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Application
    Filed: February 14, 2011
    Publication date: June 9, 2011
    Applicant: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • ANTIBODIES TO IL-17A
    Publication number: 20110052596
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Application
    Filed: October 27, 2010
    Publication date: March 3, 2011
    Applicant: SCHERING CORPORATION
    Inventors: LEONARD G. PRESTA, EDWARD P. BOWMAN
  • Agonist antibodies to IL-23 receptor
    Patent number: 7893215
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: February 22, 2011
    Assignee: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • ANTIBODIES TO IL-17A
    Publication number: 20110038878
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Application
    Filed: October 27, 2010
    Publication date: February 17, 2011
    Applicant: SCHERING CORPORATION
    Inventors: LEONARD G. PRESTA, EDWARD P. BOWMAN
  • Antibodies to IL-17A
    Patent number: 7846443
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: December 7, 2010
    Assignee: Schering Corporation
    Inventors: Leonard G. Presta, Edward P. Bowman
  • Uses of Mammalian Cytokine; Related Reagents
    Publication number: 20090285777
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 19, 2009
    Applicant: SCHERING CORPORATION
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • Methods of treating cutaneous ulcers and grafts using IL-23
    Patent number: 7575741
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: August 18, 2009
    Assignee: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Jason R. Chan
  • ANTIBODIES TO IL-17A
    Publication number: 20090175881
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Application
    Filed: August 9, 2007
    Publication date: July 9, 2009
    Inventors: Leonard G. Presta, Edward P. Bowman
  • USES OF MAMMALIAN CYTOKINE; RELATED REAGENTS
    Publication number: 20080145361
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Application
    Filed: February 5, 2008
    Publication date: June 19, 2008
    Applicant: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • Methods of treating wounds using IL-23
    Patent number: 7332156
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 19, 2008
    Assignee: Schering Corporation
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Jason R. Chan
  • Method of impairing movement of a CLA + memeory T-cell within or to the skin of a mammal by administering a CTACK antagonist
    Patent number: 6824781
    Abstract: Agonists or antagonists of CTACK or Vic chemokines, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the CTACK or Vic chemokines are specifically capable of inducing movement of a skin cell subset. Moreover, matching of ligand with GPR2 receptor in mammals provides methods of use.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: November 30, 2004
    Assignee: Schering Corporation
    Inventors: Wei Wang, Elizabeth R. Oldham, Hortensia Soto, Ying Liu, Susan A. Hudak, Bernhard Homey, Janine M. Morales, Sirid-Aimee Kellermann, Leslie M. McEvoy, Edward P. Bowman, Albert Zlotnik
  • Uses of mammalian cytokine; related reagents
    Publication number: 20040213761
    Abstract: Provided are methods of treatment for skin disorders. In particular, treatment, the skin disorders are generally inflammatory skin disorders, including improper wound healing. Provided are methods of using of a cytokine molecule.
    Type: Application
    Filed: December 18, 2003
    Publication date: October 28, 2004
    Inventors: Edward P. Bowman, Shi-Juan Chen, Daniel J. Cua, Kevin W. Moore, Tatyana Churakova, Hong-Nhung Y. Nguyen, Jason R. Chan
  • Chemokine and receptor uses; compositions; methods
    Publication number: 20020160024
    Abstract: Agonists or antagonists of CTACK or Vic chemokines, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the CTACK or Vic chemokines are specifically capable of inducing movement of a skin cell subset. Moreover, matching of ligand with GPR2 receptor in mammals provides methods of use.
    Type: Application
    Filed: July 2, 2001
    Publication date: October 31, 2002
    Applicant: Schering Corpration, a New Jersey corporation
    Inventors: Wei Wang, Elizabeth R. Oldham, Hortensia Soto, Ying Liu, Susan A. Hudak, Bernhard Homey, Janine M. Morales, Sirid-Aimee Kellermann, Leslie M. McEvoy, Edward P. Bowman, Albert Zlotnik