Patents by Inventor Edward P. Tiley

Edward P. Tiley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrolide compounds
    Patent number: 5336789
    Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: August 9, 1994
    Assignee: American Cyanamid Company
    Inventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Brian M. Bain
  • Macrolide compounds
    Patent number: 5192777
    Abstract: Compounds of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or ispropyl group; R.sup.2 represents a C.sub.2-7 alkyl group interrupted by an oxygen or sulphur atom or an aryl, aryl C.sub.1-7 alkyl or heteroaryl C.sub.1-7 alkyl group; OR.sup.3 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms; and the group .dbd.NOR.sup.2 is in the E configuration.These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: March 9, 1993
    Assignee: American Cyanamid Company
    Inventors: Michael V. J. Ramsay, Edward P. Tiley, Derek R. Sutherland
  • Macrolide compounds
    Patent number: 5185456
    Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.0 or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: February 9, 1993
    Assignee: American Cyanamid Company
    Inventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Brian M. Bain
  • Macrolide compounds
    Patent number: 5116968
    Abstract: Compounds of formula (1) ##STR1## wherein R represents a sugar residue or an acylated derivative thereof;R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2, Y.sup.2 is --CH-- and X represents ##STR2## [wherein R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.0, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.7 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; andR.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which the are attached represent >C.dbd.0 or >C.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: May 26, 1992
    Assignee: American Cyanamid Company
    Inventors: Gordon C. Lawrence, Michael J. Dawson, David Noble, Michael V. J. Ramsay, Richard Bell, Derek R. Sutherland, Edward P. Tiley
  • Macrolide compounds
    Patent number: 5112854
    Abstract: Compounds of formula (1) ##STR1## wherein R.sup.1 represents a methyl, ethyl or isopropyl group; Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## [where R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxy group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.7 is in the E configuration)] or --Y.sup.1 --X--Y.sup.2 represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; R.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent >C.dbd.O or >C.dbd.NOR.sup.7a ( where R.sup.7a is as defined above for R.sup.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: May 12, 1992
    Assignee: American Cyanamid Company
    Inventors: Michael V. J. Ramsay, Richard Bell, Peter D. Howes, Edward P. Tiley, Derek R. Sutherland
  • Macrolide compounds
    Patent number: 5057536
    Abstract: Compounds of formula (1) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## where R.sup.2 represents a hydrogen atom or a group OR.sup.8 (where OR.sup.8 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.9 (where R.sup.9 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.9 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--;R.sup.4 represents a group OR.sup.8 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent >C.dbd.O or >C.dbd.NOR.sup.9a (where R.sup.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: October 15, 1991
    Assignee: American Cyanamid Company
    Inventors: Michael J. Dawson, David Noble, Gordon C. Lawrence, Richard A. Fletton, Stephen J. Lane, Michael V. J. Ramsay, Oswy Z. Pereira, Derek R. Sutherland, Edward P. Tiley
  • Macrolide compounds
    Patent number: 5001145
    Abstract: Compounds are described of formula (1) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom or a C.sub.1-8 alkyl group and the group >C.dbd.NOR.sup.5 is in the E configuration).These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: March 19, 1991
    Assignee: American Cyanamid Company
    Inventors: Michael V. J. Ramsay, Derek N. Evans, Derek R. Sutherland, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
  • Process for the preparation of macrolide compounds
    Patent number: 4933474
    Abstract: A process is described for preparing a compound of formula (I) ##STR1## (in which R.sup.1 represents a methyl, ethyl or isopropyl group, R.sup.2 represents a hydrogen atom or a methyl or acetyl group and R.sup.3 represents a hydrogen atom, or OR.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent the group >C.dbd.0) which comprises treating a corresponding 23.alpha.- compound with a triethyloxonium salt.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: June 12, 1990
    Assignee: American Cyanamid Company
    Inventors: Edward P. Tiley, Michael V. J. Ramsay
  • Macrolide compounds
    Patent number: 4918098
    Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 a methyl, ethyl or isopropyl group;R.sup.2 is --H, --OH, substituted --OH or a phosphate ester group and R.sup.3 is --H, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent a >C=0 groupand OR.sup.4 is a group OR.sup.5 as defined above;with the proviso that either R.sup.2 represents a group OR.sup.5 (where OR.sup.5 is an alkoxy group OR.sup.7 in which R.sup.7 represents a C.sub.1-6 alkyl substituted by a halogen atom or C.sub.2-6 alkyl interrupted by --O-- or --S--) or at least one of R.sup.2 and OR.sup.4 is a phosphate ester group or a group OCONR.sup.10 R.sup.11 (where R.sup.10 and R.sup.11 are --H or C.sub.1-4 alkyl).These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: March 11, 1987
    Date of Patent: April 17, 1990
    Assignee: American Cyanamid Company
    Inventors: Michael V. J. Ramsay, Edward P. Tiley, Oswy Z. Pereira, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Derek R. Sutherland
  • Macrolid compounds
    Patent number: 4916153
    Abstract: Compounds of formula (I): ##STR1## and salts thereof; wherein R.sup.1 is --H, --OH or substituted --OH and R.sup.2 is --H, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached represent C.dbd.O, C.dbd.CH.sub.2 or C.dbd.NOR.sup.6 in the E configuration (where R.sup.6 is --H, alkyl or alkenyl);R.sup.3 is --OH or substituted --OH and R.sup.4 is --H, or R.sup.3 and R.sup.4 together with the carbon atom to which they are attached represent C.dbd.O;--A--B-- is --C(CH.sub.3).dbd.CH-- or --C(.dbd.CH.sub.2)CHX-- (where X is Cl or Br) andY is --C(R.sup.8).dbd.CHR.sup.7 -- or --C(.dbd.CH.sub.2)CHXR.sup.7 (where X is Cl or Br, R.sup.7 is methyl, ethyl or isopropyl and R.sup.8 is C.sub.2-8 alkyl or C.sub.7-15 phenalkyl); with the proviso that when --A--B-- is (.dbd.CH.sub.2)CHX--, then Y is--C(C.dbd.CH.sub.2)CHXR.sup.7.These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: March 11, 1987
    Date of Patent: April 10, 1990
    Assignee: American Cyanamid Company
    Inventors: Brian M. Bain, Paul F. Lambeth, Alison C. Rosemeyer, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley
  • Macrolide compounds
    Patent number: 4900753
    Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group .dbd.NOR.sup.2 is in the E-configuration;OR.sup.3 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms.These compounds may be used for controlling insect, acarine, nematode or other pests.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: February 13, 1990
    Assignee: American Cyanamid Company
    Inventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, Oswy Z. Pereira, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble